Microvascular Tumor Embolism: Independent Prognostic Factor After Liver Transplantation in Hepatocellular Carcinoma

Feasibility of 125I brachytherapy combined with sorafenib treatment in patients with multiple lung metastases after liver transplantation for hepatocellular carcinoma

“…It is clear that tumor recurrence and/or metastasis must be controlled in order to improve the eYcacy of OLT in HCC treatment. Studies have examined the relationship between immunosuppressive agents and recurrence Vivarelli et al 2002), explored the connection between vascular inWltration and recurrence (Lee et al 2005;Perez Saborido et al 2003), investigated the relevance of AFP level to recurrence (Shao et al 2006) and assessed the eVects of peri-surgical adjuvant therapies on recurrence (Ravaioli et al 2004). Once multiple recurrences and/or metastases appear, treatment strategies are limited; the most widely used method is post-operative chemotherapy.…”

Impact of the preoperative des-gamma-carboxy prothrombin level on prognosis after hepatectomy for hepatocellular carcinoma meeting the Milan criteria

“…However, poor differentiation and vasculobiliary invasion are well known risk factors associated with poor prognosis after liver transplantation. 13,20 Thus, liver transplantation should be avoided in HCC patients with the risk factors raised in this study. In accordance with the suggestion by Kamiyama et al, 11 hepatectomy is recommended for patients with HCC meeting the Milan criteria if they have enough hepatic functional reserve.…”

Liver Transplantation for HCC: A Review

“…In another study, 5-year survival for HCC after LT was significantly better for well and moderately differentiated tumors than poorly differentiated ones of the same size. mVI or emboli [59] has been consistently associated with poor DFS after OLT. Surrogate markers of mVI like tumor size and 18 FDG avidity have been used to refine selection criteria for LT with mixed success.…”