Microvascular Integrity Can Be Preserved by Anti-Platelet Therapy and in Combination with mTOR Inhibitor

Heim, Christian; Khan, Mohammad A.; Motsch, B.; Gocht, A.; Ramsperger-Gleixner, M.; Stamminger, Thomas; Nicolls, Mark R.; Weyand, Michael; Ensminger, Stephan

doi:10.1016/j.healun.2017.01.1069

Cited by 1 publication

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“…These effects may be related to a known antiplatelet activity of Gingko extract (Kim et al, 2011 ). Antiplatelet agents are proposed as a possible therapeutics for vascular syndromes (Geeganage et al, 2010 ; Heim et al, 2017 ). Thus, EGb761 may counteract dysfunction of neurovascular unit, which is one of the pathologies associated with AD (Farkas and Luiten, 2001 ; Zlokovic, 2011 ).…”

Section: Selected Prominent Medicinal Plants and Plant Genera Used Fomentioning

confidence: 99%

Ethnopharmacological Approaches for Dementia Therapy and Significance of Natural Products and Herbal Drugs

Tewari

Stankiewicz

Mocan

et al. 2018

Front. Aging Neurosci.

109

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Dementia is a clinical syndrome wherein gradual decline of mental and cognitive capabilities of an afflicted person takes place. Dementia is associated with various risk factors and conditions such as insufficient cerebral blood supply, toxin exposure, mitochondrial dysfunction, oxidative damage, and often coexisting with some neurodegenerative disorders such as Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease (PD). Although there are well-established (semi-)synthetic drugs currently used for the management of AD and AD-associated dementia, most of them have several adverse effects. Thus, traditional medicine provides various plant-derived lead molecules that may be useful for further medical research. Herein we review the worldwide use of ethnomedicinal plants in dementia treatment. We have explored a number of recognized databases by using keywords and phrases such as “dementia”, “Alzheimer's,” “traditional medicine,” “ethnopharmacology,” “ethnobotany,” “herbs,” “medicinal plants” or other relevant terms, and summarized 90 medicinal plants that are traditionally used to treat dementia. Moreover, we highlight five medicinal plants or plant genera of prime importance and discuss the physiological effects, as well as the mechanism of action of their major bioactive compounds. Furthermore, the link between mitochondrial dysfunction and dementia is also discussed. We conclude that several drugs of plant origin may serve as promising therapeutics for the treatment of dementia, however, pivotal evidence for their therapeutic efficacy in advanced clinical studies is still lacking.

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Section: Selected Prominent Medicinal Plants and Plant Genera Used Fomentioning

confidence: 99%

Ethnopharmacological Approaches for Dementia Therapy and Significance of Natural Products and Herbal Drugs

Tewari

Stankiewicz

Mocan

et al. 2018

Front. Aging Neurosci.

109

View full text Add to dashboard Cite

show abstract

Microvascular Integrity Can Be Preserved by Anti-Platelet Therapy and in Combination with mTOR Inhibitor

Cited by 1 publication

References 0 publications

Ethnopharmacological Approaches for Dementia Therapy and Significance of Natural Products and Herbal Drugs

Ethnopharmacological Approaches for Dementia Therapy and Significance of Natural Products and Herbal Drugs

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