Microvascular impairments detected by optical coherence tomography angiography in multiple sclerosis patients: A systematic review and meta-analysis

Liu, Jing; Song, Shuang; Gu, Xiaoya; Li, Hui; Yu, Xiaobing

doi:10.3389/fnins.2022.1121899

Cited by 6 publications

(6 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent reviews have indicated that thinning of the RFNL and ganglion cell layer in patients with ON is accompanied by a decrease in superficial and peripapillary capillary plexus density. [15][16][17][18] Vascular regression due to reduced metabolic demand, and endothelial damage caused by inflammation, have been proposed as potential causes.…”

Section: Discussionmentioning

confidence: 99%

“…However, the literature does not support this, including the authors' study. 15,25,26,29 The widening of the FAZ, and a reduction in its circularity, indicate macular ischemia. This finding is considered a marker of microvascular damage in OCTA studies, since it correlates directly with the severity of glaucoma and diabetic retinopathy, and is associated with decreased visual acuity.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Optic Coherence Tomography Angiography in Multiple Sclerosis: A Tool for Evaluation of Neuroinflammation

Elmas,

Öztürk,

Balcı

2024

Neurology the American Medical Journal

View full text Add to dashboard Cite

Purpose: This study aims to evaluate changes in retinal microvasculature in patients with multiple sclerosis (MS) by means of optic coherence tomography angiography (OCTA). Material and Methods: A total of 60 patients with MS (18 clinically isolated syndrome [CIS], 27 relapsing remitting MS [RRMS], 15 secondary progressive MS [SPMS]) and 56 healthy controls participated in the study. Demographic and clinical data, including optic neuritis history, ophthalmic examination findings, and OCTA parameters, were recorded. OCTA parameters included the following vascular structures: vascular density (VD) in the retinal superficial capillary plexus, deep capillary plexus, and radial peripapillary capillaries. Retinal nerve fiber layer as a structural spectral domain optic coherence tomography parameter was also evaluated. Results: Superficial and peripapillary vascular plexus densities and retinal nerve fiber layer thickness values were significantly reduced in patients with MS (p=0.0001). Deep capillary plexus densities showed no difference between groups (p=0.279). Patients with a previous history of optic neuritis (ON+) showed significant reduction in VD, compared to patients without a previous history of optic neuritis (ON-), and control groups (p=0.0001). The SPMS group had lower perifoveal values than patients with RRMS and CIS, and patients with RRMS had lower levels than the CIS group (p=0.012; p=0.03; p=0.035). Expanded disability status scores and VD values inversely correlated (r=-0.264; p=0.003). No significant difference between MS and control groups in the foveal avascular zone was found (p=0.296). Conclusion: OCTA findings showed reduced peripapillary and superficial vascular plexus densities in patients with MS. While this reduction was more prominent in patients with SPMS and history of optic neuritis, patients with CIS and without history of optic neuritis still showed significant reduction compared to healthy controls. These results indicate vascular regression caused by reduced metabolic demand, and microvascular damage caused by chronic inflammation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Optic Coherence Tomography Angiography in Multiple Sclerosis: A Tool for Evaluation of Neuroinflammation

Elmas,

Öztürk,

Balcı

2024

Neurology the American Medical Journal

View full text Add to dashboard Cite

show abstract

“…OCT-Angiography (OCTA) is another novel technique that has noninvasively allowed clinicians to visualize retinal and choroidal microvasculature changes in MS patients by detecting the motion contrast of blood cells [35]. In a meta-analysis that integrated retinal and choroidal OCTA data, the superficial vascular complex (SVC) and peripapillary vessel densities were found to be significantly decreased in MS patients with or without optic neuritis relative to the control group [36]. When combined with OCT-derived metrics, OCTA data was able to improve the detection of MS without optic neuritis [8].…”

Section: The Retina As a Potential Biomarker Optical Coherence Tomogr...mentioning

confidence: 99%

Oculomics analysis in multiple sclerosis: Current ophthalmic clinical and imaging biomarkers

Suh,

Hampel,

Vinjamuri

et al. 2024

Eye

View full text Add to dashboard Cite

Multiple Sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system (CNS) characterized by inflammation, demyelination, and axonal damage. Early recognition and treatment are important for preventing or minimizing the long-term effects of the disease. Current gold standard modalities of diagnosis (e.g., CSF and MRI) are invasive and expensive in nature, warranting alternative methods of detection and screening. Oculomics, the interdisciplinary combination of ophthalmology, genetics, and bioinformatics to study the molecular basis of eye diseases, has seen rapid development through various technologies that detect structural, functional, and visual changes in the eye. Ophthalmic biomarkers (e.g., tear composition, retinal nerve fibre layer thickness, saccadic eye movements) are emerging as promising tools for evaluating MS progression. The eye’s structural and embryological similarity to the brain makes it a potentially suitable assessment of neurological and microvascular changes in CNS. In the advent of more powerful machine learning algorithms, oculomics screening modalities such as optical coherence tomography (OCT), eye tracking, and protein analysis become more effective tools aiding in MS diagnosis. Artificial intelligence can analyse larger and more diverse data sets to potentially discover new parameters of pathology for efficiently diagnosing MS before symptom onset. While there is no known cure for MS, the integration of oculomics with current modalities of diagnosis creates a promising future for developing more sensitive, non-invasive, and cost-effective approaches to MS detection and diagnosis.

show abstract

“…OCT and OCTA can now be used to qualitatively and quantitatively detect the status of the retinal nerve fiber layer (RNFL), retina, and optic nerve papillae circulation. Therefore, they are currently used as clinical biomarkers for various neurological diseases ( 13 , 14 ). While previous studies on migraine hemodynamics focused on the brain using fMRI ( 15 , 16 ), several recent clinical studies have reported alterations in the retina and retinal perfusion in patients with migraine, which may provide a way to understand the ocular physiopathology observed with migraine ( 17 , 18 ).…”

Section: Introductionmentioning

confidence: 99%

Retina and microvascular alterations in migraine: a systemic review and meta-analysis

Liu,

Jie,

Wang

et al. 2023

Front. Neurol.

View full text Add to dashboard Cite

ObjectiveThis study aimed to evaluate the retina and microvascular alterations with optical coherence tomography (OCT) or optical coherence tomography angiography (OCTA) in patients with migraine with aura (MA) and migraine without aura (MO).MethodsPubMed, Embase, and Cochrane Library databases were searched to find relevant literature on patients with MA or MO using OCT/OCTA devices. The eligible data were analyzed by Stata Software (version 15.0).ResultsThere were 16 studies identified, involving 379 eyes with MA, 583 eyes with MO, and 658 eyes of healthy controls. The thickness of the peripapillary retinal nerve fiber layer (pRNFL) of patients with MA decreased significantly in most regions. The foveal avascular zone (FAZ) area and perimeter in MA patients significantly enlarged, while the perfusion density (PD) in the macular deep capillary plexus (mDCP) significantly decreased in the whole image and its subregions except for the fovea, with the PD in radial peripapillary capillary (RPC) decreasing inside the disk. Patients with MO demonstrated a significantly decreased thickness of pRNFL in most regions, and the FAZ parameters were significantly enlarged. No statistical significance was observed in the retina and microvascular features of patients with MA and MO.ConclusionThe eyes affected by MA and MO demonstrated significantly reduced thickness of pRNFL and enlarged FAZ. Patients with MA showed retinal microvascular impairments, including a decreased PD in mDCP. The OCT and OCTA could detect membrane morphology and circulation status in migraine and might provide the basis for the diagnosis and follow-up of patients with migraine.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, CRD42023397653.

show abstract

Microvascular impairments detected by optical coherence tomography angiography in multiple sclerosis patients: A systematic review and meta-analysis

Cited by 6 publications

References 34 publications

Optic Coherence Tomography Angiography in Multiple Sclerosis: A Tool for Evaluation of Neuroinflammation

Optic Coherence Tomography Angiography in Multiple Sclerosis: A Tool for Evaluation of Neuroinflammation

Oculomics analysis in multiple sclerosis: Current ophthalmic clinical and imaging biomarkers

Retina and microvascular alterations in migraine: a systemic review and meta-analysis

Contact Info

Product

Resources

About