Microvascular function in women with former gestational diabetes: A cohort study

Abstract

Objective: In the long term, diabetes mellitus is potentially associated with the occurrence of microvascular damage. This study sought to assess whether a history of prior gestational diabetes mellitus is associated with long-term effects on the women's microcirculation. Methods: Within the scope of a long-term follow-up of the 'Viennese Post-Gestational Diabetes Project', women with prior gestational diabetes mellitus as well as women with previous pregnancy but with no history of gestational diabetes mellitus (controls) were enrolled in this cross-sectional study. Microvascular function was assessed by post-occlusive reactive hyperaemia using laser Doppler fluxmetry. Baseline perfusion, biological zero, peak perfusion, time to peak and recovery time were recorded and compared between both groups. Results: Microvascular function was assessed in 55 women with prior gestational diabetes mellitus (46.1 ± 4.6 years) and 32 women with previous pregnancy but without prior gestational diabetes mellitus (42.9 ± 5.3 years). The mean period of time between delivery and the assessment of microvascular function was 16.2 ± 5.2 years in women with prior gestational diabetes mellitus group and 14.2 ± 4.8 years in controls. Regarding microvascular function, baseline perfusion, biological zero, peak perfusion, time to peak and recovery time did not differ between women with prior gestational diabetes mellitus and controls (all p > 0.05). Conclusion:In the long term, microvascular function appears not to be impaired in women with prior gestational diabetes mellitus.

RETRACTED ARTICLE: Effect of rosuvastatin on fasting and postprandial endothelial biomarker levels and microvascular reactivity in patients with type 2 diabetes and dyslipidemia: a preliminary report

“…Our present study also has several advantages. First, we assessed circulation in small vessels using laser Doppler flowmetry, which has been validated for assessing endothelial dysfunction [ 17 , 18 ]. Second, a standardized mixed-meal was given to the study participants to measure postprandial levels of PON-1 and ADMA in a standardized fashion.…”

“…Vascular health was assessed by microcirculation using a laser Doppler system in a fasting state in both controls and patients, and was repeated after 12 weeks of rosuvastatin treatment only in the patient group. To measure microvascular flow, a Laser Doppler perfusion monitor system (PeriFlux System 5000, Perimed, Stockholm, Sweden) was used [ 18 ]. This system operates with two laser diodes that emit light with a wavelength of 780 nm.…”

“…Microvascular reactivity is attenuated in insulin-resistant conditions, and is an independent marker of future cardiovascular events in patients with T2D. Therefore, it has been recently adopted to assess endothelial function at an early stage [ 17 , 18 ].…”

Micro- and macrovascular function in patients suffering from primary adrenal insufficiency: a cross-sectional case–control study

“…The control group consisted of 27 healthy female volunteers without a history of disturbed glucose tolerance, severe obesity, hypertension and cardiovascular diseases. Data of the control group were in parts published previously [ 22 ]. Of note, subjects in this historical control group were significantly younger than patients with primary AI.…”

“…LDF measurements in the control group had been performed using PIM II laser Doppler perfusion measurement system (with LISCA Opto-Isolation Unit; Perimed, Järfälla, Sweden) and details on the measurement setup have been published previously [ 22 ]. To account for potential confounders due to different instruments we compared the relative changes of perfusion between the groups.…”