Microvascular Dysfunction Is Associated With Worse Cognitive Performance

Abstract

People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal. If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the "Taverne" license above, please follow below link for the End User Agreement:

Associations between self-reported sleep characteristics and incident mild cognitive impairment: The Heinz Nixdorf Recall Cohort Study

“…In concordance, a specific pathway between long sleep duration and cognitive decline is not known. Long sleep duration is associated with cerebrovascular disease 43,44 which is a contributor to cognitive impairment and cognitive decline 45,46 . Persons with cardiovascular disease have more often problems in maintaining sleep 47,48 .…”

Inequalities in Cognitive Impairment Among Older Adults in China and the Associated Social Determinants: A Decomposition Approach

“…Increasing age is a well-known major risk factor of the onset of cognitive impairment and dementia [41]. Studies have shown that with the increase of age, the effectiveness of dopamine neurotransmission decreases [42] and different degrees of microvascular dysfunction occur, thus affecting the decline of cognitive function [43]. Moreover, the possibility of cognitive impairment in the old-old is much higher than that in the youngold.…”

Associations of Arterial Stiffness With Cognitive Performance, and the Role of Microvascular Dysfunction

“…A detailed description all MVD measures is provided in Item S2, and has been described previously. 2 Brain MRI measurements were implemented from December 2013 onward and were available in 2313 of 3451 participants (67%). Brain MRI was performed on a 3T MRI scanner (Siemens Magnetom Prisma-fit Syngo MR D13D, Erlangen, Germany).…”

“…1 The cerebral microvasculature regulates many processes potentially affecting cognition, that is, cerebral perfusion, neurogenesis, neurovascular coupling, blood-brain barrier permeability, and cerebral autoregulation. 2 Impairment of these processes may lead to neuronal dysfunction and ischemia, which may ultimately lead to lower cognitive performance. 3 In accordance, previous studies [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] have shown an association between greater arterial stiffness and worse cognitive performance and incident dementia.…”

“…We previously showed that such a MVD composite score is associated with worse cognitive performance. 2 In view of the above, the aims of the present study were to investigate the associations between aortic and carotid stiffness and cognitive performance, and to test whether any such associations are statistically mediated by a score of various MVD measures, including CSVD features, retinal arteriolar and venular dilation response, UAE, and plasma biomarkers of MVD.…”