Microvascular dysfunction

Studying the human lower limb perfusion dynamics with the step in place model

“…A marcha é frequentemente referida como o "sexto sinal vital", associado ao estilo de vida funcional e pode ser utilizada como um instrumento de reabilitação para ativação do multi-sistema vascular no membro inferior. As diferenças endócrinas relacionadas ao sexo na função endotelial têm sido avaliadas [5], assim como outros estudos abordaram a relação entre disfunção microcirculatória e eventos cardiovasculares frequentemente associados a estilos de vida a hábitos sedentários e de inatividade [6][7]. A marcha disfuncional é uma marcha de qualidade reduzida com compensações que consomem ao indivíduo aproximadamente mais 40% de oxigénio do que aquela que é realizada em padrões normais [8][9][10].…”

“…Sex related endocrine differences on endothelial function have been assessed [5]. Other studies addressed the relationship between microvascular dysfunction and cardiovascular events often linked to lifestyles based on sedentary habits and inactivity [6][7]. Dysfunctional walking was suggested to decrease gait quality, and consume approximately 40% more oxygen than normal (walking) individuals [8][9][10].…”

Genetic Polymorphisms and Ischemic Heart Disease

“…Several studies show that different single-nucleotide polymorphisms of different genes can be involved. Single-nucleotide polymorphisms within genes of MYH15, linked to the maintenance of tonic force in vascular smooth muscle cells, VEGFA, involved in cell proliferation, migration, and angiogenic potential and NT5E which contributes to overall microvessel stiffness were associated with microvascular dysfunction in men [63,77]. Studies on polymorphisms at the cholesteryl ester transfer protein (CETP) locus showed that women displayed a higher HDL-C than men and an equally high incidence of coronary heart disease in B2 homozygotes as in other genotypes [78].…”

“…PKC-mediated regulation of sarcolemmal ATP-dependent K [sarcK(ATP)] channels may account for the gender difference in cardioprotection upon both PKC and sarcK(ATP). It involves PKC-dependent sarcolemma increase with a major expression of sarcK(ATP) in female [77]. Microcirculation dysfunction can also be associated with cardiac hypertrophy, which can be related to the expression of Kvβ1.1, particularly in females.…”