Microvascular complications assessment in adolescents with 2- to 5-yr duration of type 1 diabetes from 1990 to 2006

Cho, Yoon Hi; Craig, Maria E.; Hing, Stephen; Gallego, Patricia; Poon, Myra; Chan, Albert; Donaghue, Kim C.

doi:10.1111/j.1399-5448.2011.00762.x

Cited by 84 publications

(74 citation statements)

References 22 publications

(30 reference statements)

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“…In some of them, elevation of AER might be triggered by puberty and regression of microalbuminuria was the consequence of the end of the pubertal period. Age at onset of diabetes was an independent risk factor for the development of microalbuminuria in our cohort of patients, which additionally underlines the importance of endocrine changes during the puberty period for the manifestation of microalbuminuria, even in diabetics with very short disease duration [36]. Factors which showed significant association with the odds of developing microalbuminuria additionally included BMI and variability of HbA 1c .…”

Section: Discussionsupporting

confidence: 62%

Kontrola glikemii i jej zmienność głównymi czynnikami ryzyka mikroalbuminurii u dzieci chorych na cukrzycę typu 1

Nazim¹,

Fendler²,

Starzyk³

2014

Endokrynologia Polska

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Introduction: To assess in a prospective study the course and the predictors of microalbuminuria in children and adolescents with type 1 diabetes. Material and methods: 438 children and adolescents who developed diabetes in the years 1985-2004 were followed for 9.2 ± 3.4 years from the diagnosis. Microalbuminuria was assessed on the basis of timed overnight urine collections performed once per year. Variability of glycated haemoglobin was expressed as a coefficient of variation (%) calculated by dividing standard deviation (adjusted for the number of measurements) by mean of HbA 1c .Results: Microalbuminuria was noted in 99 patients (22.6%) after 8.27 ± 3.3 years of diabetes. In 29 individuals (6.6%), microalbuminuria was persistent. The prevalence of microalbuminuria was not dependent on the period of diabetes diagnosis. During followup, 17 (58.6%) patients with persistent MA reverted to normoalbuminuria. Children without any episodes of microalbuminuria had significantly lower HbA 1c variability (8.44%; 95% CI 7.81-9.08%) than those with one (10.28% 95% CI 9.10-11.47%; p = 0.007).

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Section: Discussionsupporting

confidence: 62%

Kontrola glikemii i jej zmienność głównymi czynnikami ryzyka mikroalbuminurii u dzieci chorych na cukrzycę typu 1

Nazim¹,

Fendler²,

Starzyk³

2014

Endokrynologia Polska

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“…The fact that fetuin A is considered a cardiovascular risk marker underlines its potential relevance in the young T1D patient, as vascular changes begin early [58]. However, previous data on fetuin A and atherosclerosis in non-T1D cohorts are inconsistent: both low and high fetuin A concentrations were associated with cardiovascular disease and mortality risk [21-23].…”

Section: Discussionmentioning

confidence: 99%

Relationship of Serum Fetuin A with Metabolic and Clinical Parameters in German Children and Adolescents with Type 1 Diabetes

et al. 2017

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Background and Aim: The hepatokine fetuin A is upregulated in the metabolic syndrome and in type 2 diabetes (T2D), while its role in adolescent type 1 diabetes (T1D) is unclear. We assessed the relationship between circulating fetuin A levels and metabolic control, comorbidities, and complications in adolescent T1D patients. Methods: We studied the relationship between serum fetuin A and clinical diabetes-related data from the DPV registry (Diabetes-Patienten-Verlaufsdokumentation) in 172 adolescent T1D patients with early-onset (<5 years) long-standing (>10 years) T1D. Fetuin A levels were further compared between adolescent T1D and T2D patients. Results: Serum fetuin A levels in T1D patients (mean 0.267 ± 0.043 g/L) did not correlate with age, diabetes duration, gender, body mass index (BMI), glycated hemoglobin, serum lipid levels, blood pressure, celiac or thyroid disease, nephropathy, or retinopathy. An association of fetuin A levels with insulin requirements was only evident within the subgroup of overweight T1D patients (r_s = 0.439, p = 0.028, n = 25, BMI >90th percentile), disappearing after adjustment for multiple testing. Adolescent T1D patients showed distinctly lower fetuin A levels than patients with T2D (p ≤ 0.001). Conclusion: Overall, we did not observe a clinically relevant association of fetuin A levels with surrogate parameters for insulin sensitivity in our juvenile T1D cohort. A correlation with insulin requirements was detectable in overweight patients only. We hypothesize that multiple factors, such as obesity, puberty, inadequate metabolic control, and hepatic steatosis, have to add up before a clinically relevant effect of fetuin A on insulin sensitivity becomes evident.

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“…The estimated between-person standard deviation of the decrease was 3.3 (95% CI 1.8 to 4.7) ml/minute per year, so 74% of male patients and 82% of female patients will have a decreasing eGFR. The within-measurement 1 Cho et al 143 Orchard et al (Pittsburgh) 51 Salgado et al 146 Andersen et al…”

Section: Glomerular Filtration Ratementioning

confidence: 99%

“…14 Because ORPS was primarily a study of young people with type 1 diabetes (maximum age 35 by end of follow-up), we compared model predictions to the prevalences of microalbuminuria and macroalbuminuria after diagnosis reported by other large studies of people up to 40 years ( Figure 10). 1,51,[141][142][143][144][145][146][147] The studies used different criteria (e.g. number of confirmatory tests) for diagnosing microalbuminuria.…”

Section: Doi: 103310/hta18140mentioning

confidence: 99%

Optimal strategies for identifying kidney disease in diabetes: properties of screening tests, progression of renal dysfunction and impact of treatment – systematic review and modelling of progression and cost-effectiveness

Farmer

Stevens

Hirst

et al. 2014

Health Technology Assessment

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Microvascular complications assessment in adolescents with 2- to 5-yr duration of type 1 diabetes from 1990 to 2006

Abstract: Early complications are not uncommon in adolescents with 2- to 5-yr diabetes duration, despite more intensive management in recent years.

Cited by 84 publications

References 22 publications

Kontrola glikemii i jej zmienność głównymi czynnikami ryzyka mikroalbuminurii u dzieci chorych na cukrzycę typu 1

Kontrola glikemii i jej zmienność głównymi czynnikami ryzyka mikroalbuminurii u dzieci chorych na cukrzycę typu 1

Relationship of Serum Fetuin A with Metabolic and Clinical Parameters in German Children and Adolescents with Type 1 Diabetes

Optimal strategies for identifying kidney disease in diabetes: properties of screening tests, progression of renal dysfunction and impact of treatment – systematic review and modelling of progression and cost-effectiveness

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