Microvascular blood flow of the optic nerve head and peripapillary retina in unilateral exfoliation syndrome

Abstract

ABSTRACT.Purpose: To measure microvascular blood flow in patients with unilateral exfoliation syndrome (XFS) without glaucoma or ocular hypertension and to compare the values in the eyes with clinically detected exfoliation, their nonexfoliative fellow eyes of the same patients and control eyes. Methods: Twenty-two patients with clinically detected unilateral XFS and 30 age-matched healthy subjects were included in this study. Group 1 consisted of 22 eyes with clinical XFS, and the nonexfoliative fellow eyes of the same patients formed Group 2. The control group (Group 3) comprised the randomly selected eyes of 30 age-matched healthy subjects. Ocular blood flow values (volume, flow and velocity) were recorded from the optic nerve head (ONH) and peripapillary retina (PPR) using the Heidelberg retinal flowmeter (HRF). The differences between the three groups were compared statistically. Results: The mean values of blood flow obtained from the ONH and PPR in eyes with clinically detected exfoliation (Group 1) and their nonexfoliative fellow eyes (Group 2) were both significantly lower than the values for the control eyes (Group 3). The differences in ocular blood flow between the eyes with exfoliation and the nonexfoliative fellow eyes were not statistically significant [one-way analysis of variance (ANOVA), Dunnett's T3 test, p ‡ 0.05). Conclusion: These findings suggest that the eyes with clinically detected unilateral XFS were associated with reduced blood flow values in both the ONH and the PPR. The nonexfoliative fellow eyes also have lower blood flow values than the control eyes.

Ocular haemodynamics in pseudoexfoliative and primary open-angle glaucoma

“…It may be argued that the differences between the results of the Yü ksel study and our results may be due to the use of topical therapy in the Yü ksel study. Although several papers have reported systemic and ocular vascular alterations in patients with pseudoexfoliation syndrome, [20][21][22][23] our results suggested that the OBF alterations were stronger in the POAG patients group.…”

Elevated neutrophil-to-lymphocyte ratio in pseudoexfoliation syndrome

“…6 The cellular stress conditions such as oxidative stress, inflammation, ischemia and hypoxia play a role in the pathophysiology of PEXS and PEXG. 7,8 A clear role for inflammatory mediators and cells has been established in recent years.…”

“…4,5 The inflammation is an important component of various age-related diseases such as: Alzheimer's disease and atherosclerosis. 6 The role of neutrophil/lymphocyte ratio (NLR) in cardiovascular and cancer diseases has been reported 4,5 but the relation with the ocular diseases is unclear.…”

Evaluation of Choroidal Thickness in Patients with Pseudoexfoliation Syndrome

“…24,25 Ayrıca, oküler kan akımını azalttığına dair çalış-malar mevcuttur. 5,6,[13][14][15] Yüksel ve ark., PEX sendromlu ve PEX glokomlu hastalarda retrobulber kan akımında deği-şiklikler saptamış, kan akım velositesinde azalma ve vasküler rezistansta artış olduğunu göstermiş, bu bulguların PEX materyalinin damar duvarlarında birikmesi sonucu olduğunu ileri sürmüşlerdir. 5 Ocakoğlu ve ark.…”

“…[10][11][12] Literatürde çalışmalar olmakla birlikte, psödoeksfo-liatif materyalin koroid kan akımı ve koroid kalınlığına etkisi tartışmalıdır. 5,6,[13][14][15][16][17][18][19][20][21][22] Bu çalışmada, PEX sendromlu hastalarda ve sağlıklı bireylerde makuler koroid kalınlığının değerlendirilip sağlıklı gözlerle karşılaştırılması amaçlanmıştır.…”