Microvascular Architecture of Breast Lesions

Du, Jing; Li, Fenghua; Fang, Hua; Xia, Jianguo; Zhu, Caixia

doi:10.7863/jum.2008.27.6.833

Cited by 78 publications

(20 citation statements)

References 19 publications

(12 reference statements)

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“…In our study, we described some special imaging findings in malignant breast tumors, including irregular shape, heterogeneous enhancement of contrast agents, surrounding and penetrating vessels, local perfusion, an increase in size after contrast agent administration, quantitative parameters such as shortened time to peak enhancement, and increased peak intensity. These features were consistent with the results of other studies (12,19,20).…”

Section: Discussionsupporting

confidence: 95%

“…24.0 + 10.5 mm before to 26.8 + 10.4 mm after contrast injection (P , 0.05). As to the time-intensity curve and quantitative parameters in the malignancies: the mean AT, TTP, PI were 11.9 + 4.3 s, 19.7 + 4.6 s, 5.5 + 3.0, respectively. Tables 1 and 2 summarize the CEUS enhancement characteristics and timeintensity curve parameters based on different histopathology of breast cancers.…”

Section: Conventional Us Findingsmentioning

confidence: 98%

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Contrast-enhanced ultrasonographic findings of different histopathologic types of breast cancer

Wang

et al. 2011

Acta Radiol

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Section: Discussionsupporting

confidence: 95%

Section: Conventional Us Findingsmentioning

confidence: 98%

Contrast-enhanced ultrasonographic findings of different histopathologic types of breast cancer

Wang

et al. 2011

Acta Radiol

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“…Breast cancer is known to have a higher microvessel density than benign lesions. Special CEUS software exists that can analyze the dynamic vascular pattern, giving more information about the possibility of malignancy in a defined mass [18]. However, CEUS cannot easily distinguish malignant from benign reactive nodes.…”

Section: Discussionmentioning

confidence: 99%

Contrast-Enhanced Color Doppler Ultrasonography for Preoperative Evaluation of Sentinel Lymph Node in Breast Cancer Patients

et al. 2015

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Background: Sentinel lymph node (SLN) biopsy is the standard of care for breast cancer patients with non-palpable axillary lymph nodes. We evaluated the usefulness of contrast-enhanced ultrasonography in preoperative detection of malignant SLNs. Methods: 50 patients with breast cancer (median age: 60 years) underwent a color power Doppler ultrasonography with intravenous contrast (Sonovue®) preoperatively, and findings suggestive of metastatic disease to the SLN were documented. The final histopathological report and the radiological preoperative record were compared. Finally, the sensitivity, specificity and diagnostic accuracy of this evolving diagnostic modality were calculated. Results: Contrast-enhanced ultrasound scan identified a negative SLN in the axilla of 27 patients and final histopathology was negative for 30 cases in total, so negative predictive value was calculated as 90% and positive predictive value was 75%. Overall sensitivity was 83.33% and specificity was 84.38%. Moreover, the ability of contrast-enhanced ultrasound to differentiate between SLN status was only statistically significantly correlated with the actual final histopathological report (p < 0.001), while successful ultrasound prediction was not correlated with any factor. Conclusions: SLN status can be evaluated preoperatively using contrast-enhanced color Doppler ultrasonography with high accuracy.

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“…In addition, the individual vessels are compromised, with larger inter-endothelial junctions, increased fenestrations, vesicles and vesicovascular channels and lack of normal basement membrane. These features result in lower perfusion rates (blood flow per volume), lower red blood cell velocity, heterogenous and chaotic blood flow around the tumor periphery, and a situation in which plasma oozes from the tumor periphery into the surrounding normal tissues [44]–[46]. These abnormalities in blood flow dynamics generate different temporally-varying conductivity environments than those associated with the benign breast.…”

Section: Discussionmentioning

confidence: 99%

Real-Time Electrical Impedance Variations in Women With and Without Breast Cancer

Halter

Hartov

Poplack

et al. 2015

IEEE Trans. Med. Imaging

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The chaotic vascular network surrounding malignant tumors leads to pulsatile blood flow patterns that differ from those in benign regions of the breast. This study aimed to determine if high-speed electrical impedance tomography (EIT) is able to detect conductivity changes associated with cyclic blood-volume changes and to gauge the potential of using these signatures to differentiate malignant from benign regions within the breast. EIT imaging of pulsating latex membranes submerged in saline baths provided initial validation of its use for tracking temporally varying conductivities. Nineteen women (10 with cancer, nine without) were imaged with EIT over the course of several heartbeats in synchrony with pulse-oximetry acquisition. Eight parameters (rs, φ(rt,max), rt,max, Plow:full, Phigh:full, Plow:high) relating the conductivity images and pulse-oximeter signatures were extracted and used as a means of comparing malignant and benign regions of the breast. Significant differences (p < 0.01) between malignant and benign regions of interest were noted in seven of the eight parameters. The maximum correlation between conductivity and pulse-oximeter signals, rt,max, was observed to be the optimal discriminating parameter with a receiver operating characteristic area under the curve of 0.8 and a specificity of 81% at a sensitivity of 77%. Assessing the dynamic conductivity of breast may provide additional clinical utility to that of standard imaging modalities, but further investigation is necessary to better understand the biophysical mechanisms leading to the observed conductivity changes.

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Microvascular Architecture of Breast Lesions

Abstract: Micro flow imaging can clearly delineate the microvascular architecture of breast lesions and can aid in discrimination between benign and malignant breast lesions.

Cited by 78 publications

References 19 publications

Contrast-enhanced ultrasonographic findings of different histopathologic types of breast cancer

Contrast-enhanced ultrasonographic findings of different histopathologic types of breast cancer

Contrast-Enhanced Color Doppler Ultrasonography for Preoperative Evaluation of Sentinel Lymph Node in Breast Cancer Patients

Real-Time Electrical Impedance Variations in Women With and Without Breast Cancer

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