Microtubule Structure, Organization and Defects: Spinal Muscular Atrophy and Amyotrophic Lateral Sclerosis

Sleep and Melatonin

“…In humans, NREM sleep can be categorized into four stages based on electroencephalographic patterns. NREM-I and II are sometimes called light sleep, whereas NREM-III and IV are referred to as slowwave sleep or deep sleep [6], [7].…”

“…It represents the deepest stage of sleep and is characterized by a high threshold for waking reactions. If someone attempts to wake a person during this stage, it often results in heightened drowsiness or immobility (sleep inertia) immediately after awakening, and the individual may feel confused [7], [8]. REM Sleep: Also known as rapid eye movement sleep or paradoxical sleep, it is characterized by muscle atonia, except for essential skeletal muscles like the diaphragm, along with rapid eye movements.…”