Microtubule Dynamics may Embody a Stationary Bipolarity Forming Mechanism Related to the Prokaryotic Division Site Mechanism (Pole-to-Pole Oscillations)

Hunding, Axel

doi:10.1007/s10867-004-3387-7

Cited by 6 publications

(4 citation statements)

References 90 publications

(91 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This may have been a prelude to modern prokaryotic and eukaryotic cell division mechanisms. (60) In addition, our theory can also explain how encoded, linear replication evolved secondarily as part of the general evolution of catalyzed polymerization reactions. Some polymerization reactions can occur spontaneously in solution.…”

Section: The Evolution Of Composomal Functionmentioning

confidence: 97%

Compositional complementarity and prebiotic ecology in the origin of life

Hunding¹,

Képès²,

Lancet³

et al. 2006

BioEssays

100

View full text Add to dashboard Cite

We hypothesize that life began not with the first self-reproducing molecule or metabolic network, but as a prebiotic ecology of co-evolving populations of macromolecular aggregates (composomes). Each composome species had a particular molecular composition resulting from molecular complementarity among environmentally available prebiotic compounds. Natural selection acted on composomal species that varied in properties and functions such as stability, catalysis, fission, fusion and selective accumulation of molecules from solution. Fission permitted molecular replication based on composition rather than linear structure, while fusion created composomal variability. Catalytic functions provided additional chemical novelty resulting eventually in autocatalytic and mutually catalytic networks within composomal species. Composomal autocatalysis and interdependence allowed the Darwinian co-evolution of content and control (metabolism). The existence of chemical interfaces within complex composomes created linear templates upon which self-reproducing molecules (such as RNA) could be synthesized, permitting the evolution of informational replication by molecular templating. Mathematical and experimental tests are proposed.

show abstract

Section: The Evolution Of Composomal Functionmentioning

confidence: 97%

Compositional complementarity and prebiotic ecology in the origin of life

Hunding¹,

Képès²,

Lancet³

et al. 2006

BioEssays

100

View full text Add to dashboard Cite

show abstract

“…The dynamics of Ten-m is described in analogy with an earlier model by [ 53 ], which is further akin to a model by [ 54 ] on protein binding to the cell membrane, in the context of prokaryotic cell division. The main feature of this model has been experimentally verified with in vitro experiments and further modeling [ 55 ].…”

Section: Resultsmentioning

confidence: 99%

Ancient role of ten-m/odz in segmentation and the transition from sequential to syncytial segmentation

Hunding

Baumgärtner

2017

Hereditas

View full text Add to dashboard Cite

BackgroundUntil recently, mechanisms of segmentation established for Drosophila served as a paradigm for arthropod segmentation. However, with the discovery of gene expression waves in vertebrate segmentation, another paradigm based on oscillations linked to axial growth was established. The Notch pathway and hairy delay oscillator are basic components of this mechanism, as is the wnt pathway. With the establishment of oscillations during segmentation of the beetle Tribolium, a common segmentation mechanism may have been present in the last common ancestor of vertebrates and arthropods. However, the Notch pathway is not involved in segmentation of the initial Drosophila embryo. In arthropods, the engrailed, wingless pair has a much more conserved function in segmentation than most of the hierarchy established for Drosophila. ResultsHere, we work backwards from this conserved pair by discussing possible mechanisms which could have taken over the role of the Notch pathway. We propose a pivotal role for the large transmembrane protein Ten-m/Odz. Ten-m/Odz may have had an ancient role in cell-cell communication, parallel to the Notch and wnt pathways. The Ten-m protein binds to the membrane with properties which resemble other membrane-based biochemical oscillators.ConclusionWe propose that such a simple transition could have formed the initial scaffold, on top of which the hierarchy, observed in the syncytium of dipterans, could have evolved.

show abstract

“…Recall from Section 3.2 an intricate mechanism in which concentration oscillations of Min proteins mediated division of prokaryotic cells. In the next section, we will see how eukaryotes achieve the same result with a very different mechanism [194] involving coupling of RD to cytoskeletal fibers called microtubules.…”

Section: Reaction-diffusion Systemsmentioning

confidence: 99%

Reaction‐Diffusion Systems in Intracellular Molecular Transport and Control

et al. 2010

View full text Add to dashboard Cite

Chemical reactions make cells work only if the participating chemicals are delivered to desired locations in a timely and precise fashion. While most research to date has focused on the so-called active-transport mechanisms, “passive” diffusion is often equally rapid and is always energetically less costly. Capitalizing on these advantages, cells have developed sophisticated reaction-diffusion (RD) systems that control a wide range of cellular functions – from chemotaxis and cell division, through signaling cascades and oscillations, to cell motility. Despite their apparent diversity, these systems share many common features and are “wired” according to “generic” motifs involving non-linear kinetics, autocatalysis, and feedback loops. Understanding the operation of these complex (bio)chemical systems requires the analysis of pertinent transport-kinetic equations or, at least on a qualitative level, of the characteristic times describing constituent sub-processes. Therefore, in reviewing the manifestations of cellular RD, we also attempt to familiarize the reader with the basic theory of these processes.

show abstract

Microtubule Dynamics may Embody a Stationary Bipolarity Forming Mechanism Related to the Prokaryotic Division Site Mechanism (Pole-to-Pole Oscillations)

Cited by 6 publications

References 90 publications

Compositional complementarity and prebiotic ecology in the origin of life

Compositional complementarity and prebiotic ecology in the origin of life

Ancient role of ten-m/odz in segmentation and the transition from sequential to syncytial segmentation

Reaction‐Diffusion Systems in Intracellular Molecular Transport and Control

Contact Info

Product

Resources

About