Microtubule-associated protein MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells

Verma, Rita; Aggarwal, Parul; Bischoff, Megan E.; Reigle, James; Secic, Dina; Wetzel, Collin; VandenHeuvel, Katherine; Biesiada, Jacek; Ehmer, Birgit; Figueroa, Julio A. Landero; Plas, David R.; Medvedovic, Mario; Meller, Jarosław; Czyzyk-Krzeska, Maria F.

doi:10.1016/j.jbc.2023.104663

Cited by 3 publications

(1 citation statement)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since lysosomal exocytosis is dependent on vesicular transport between the cell center and the cell periphery, it is not surprising that proteins involved in lysosomal trafficking often are deregulated in cancer. The loss of the microtubule-associated protein 1 light chain 3 gamma (LC3C) results in a peripheral redistribution of lysosomes, enhanced exocytosis, and more aggressive tumors [ 297 ]. Moreover, an altered expression of proteins regulating anterograde and retrograde transport of lysosomes is found in various cancers.…”

Section: Lysosomal Involvement In Cancermentioning

confidence: 99%

Lysosomes in Cancer—At the Crossroad of Good and Evil

Eriksson,

Öllinger

2024

Cells

View full text Add to dashboard Cite

Although it has been known for decades that lysosomes are central for degradation and recycling in the cell, their pivotal role as nutrient sensing signaling hubs has recently become of central interest. Since lysosomes are highly dynamic and in constant change regarding content and intracellular position, fusion/fission events allow communication between organelles in the cell, as well as cell-to-cell communication via exocytosis of lysosomal content and release of extracellular vesicles. Lysosomes also mediate different forms of regulated cell death by permeabilization of the lysosomal membrane and release of their content to the cytosol. In cancer cells, lysosomal biogenesis and autophagy are increased to support the increased metabolism and allow growth even under nutrient- and oxygen-poor conditions. Tumor cells also induce exocytosis of lysosomal content to the extracellular space to promote invasion and metastasis. However, due to the enhanced lysosomal function, cancer cells are often more susceptible to lysosomal membrane permeabilization, providing an alternative strategy to induce cell death. This review summarizes the current knowledge of cancer-associated alterations in lysosomal structure and function and illustrates how lysosomal exocytosis and release of extracellular vesicles affect disease progression. We focus on functional differences depending on lysosomal localization and the regulation of intracellular transport, and lastly provide insight how new therapeutic strategies can exploit the power of the lysosome and improve cancer treatment.

show abstract

Section: Lysosomal Involvement In Cancermentioning

confidence: 99%