“…The search for such markers would be facilitated by the establishment of stable animal models of chronic rejection after liver transplantation. Rat models of chronic rejection after transplantation of the heart, kidney, aorta and other tissues, and models of acute rejection after orthotopic liver transplantation (OLT) have been successfully established [5,6,7,8,9], but there have been few reports of a chronic rejection model in rats after OLT [10,11]. The objective of this study was to establish a stable chronic rejection model after OLT in the rat and describe the pathological features of the model.…”