Microstructured Nickel-Titanium Thin Film Leaflets for Hybrid Tissue Engineered Heart Valves Fabricated by Magnetron Sputter Deposition

Loger, Klaas; Engel, Andréas; Haupt, J.; Miranda, Rodrigo Lima de; Lutter, Georg; Quandt, Eckhard

doi:10.1007/s13239-015-0254-6

Cited by 10 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their results showed higher effective opening area, lower systolic transvalvular pressure due to increased cardiac output and low flow resistance. They suggest further design optimization with increased duration of cell seeding process as well as addition of cardiac fibroblasts and VECs could improve the durability of their NiTi thin film leaflets (Loger et al, 2016; Figure 2A).…”

Section: Tissue-engineered Heart Valves (Tehvs)mentioning

confidence: 99%

See 1 more Smart Citation

Biomaterials in Valvular Heart Diseases

Taghizadeh

Ghavami

Derakhshankhah

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Valvular heart disease (VHD) occurs as the result of valvular malfunction, which can greatly reduce patient’s quality of life and if left untreated may lead to death. Different treatment regiments are available for management of this defect, which can be helpful in reducing the symptoms. The global commitment to reduce VHD-related mortality rates has enhanced the need for new therapeutic approaches. During the past decade, development of innovative pharmacological and surgical approaches have dramatically improved the quality of life for VHD patients, yet the search for low cost, more effective, and less invasive approaches is ongoing. The gold standard approach for VHD management is to replace or repair the injured valvular tissue with natural or synthetic biomaterials. Application of these biomaterials for cardiac valve regeneration and repair holds a great promise for treatment of this type of heart disease. The focus of the present review is the current use of different types of biomaterials in treatment of valvular heart diseases.

show abstract

Section: Tissue-engineered Heart Valves (Tehvs)mentioning

confidence: 99%

“…Reprinted with permission from Yousefi et al (2017). Copyright (2017), Springer Nature.materials in PHVs fabrication(Van Putte et al, 2012;Loger et al, 2016;…”

mentioning

confidence: 99%

Biomaterials in Valvular Heart Diseases

Taghizadeh

Ghavami

Derakhshankhah

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Ni–Ti alloy has been widely used in biomedical applications because of its unique shape memory effect and superelasticity. 1 , 2 SS has been used as ureteral stents, orthopedic devices, orthodontic brackets, and wires because of its superior mechanical properties. 3 , 4 Although SS provides excellent biomechanical properties compared to other alloys, the reduced corrosion resistance and biocompatibility of SS restrict its clinical application.…”

Section: Introductionmentioning

confidence: 99%

Corrosion Behavior and In Vitro Cytotoxicity of Ni–Ti and Stainless Steel Arch Wires Exposed to Lysozyme, Ovalbumin, and Bovine Serum Albumin

Zhang

Chen

et al. 2020

ACS Omega

View full text Add to dashboard Cite

In this study, the tendency and mechanisms by which protein and mechanical loads contribute to corrosion were determined by exposing Ni–Ti and stainless steel arch wires under varying mechanical loads to artificial saliva containing different types of protein (lysozyme, ovalbumin, and bovine serum albumin). The corrosion behavior and in vitro cytotoxicity results show that exposure to both protein and mechanical stress significantly decreased the corrosion resistance of stainless steel and increased the release of toxic corrosion products. Adding protein inhibited the corrosion of Ni–Ti, but the mechanical loads counteracted this effect. Even proteins containing the same types of amino acids had different effects on the corrosion resistance of the same alloy. The effect of protein or stress, or their combination, should be considered in the application of metal medical materials.

show abstract

“…Using a micro-system technology process developed by 2013 [7], freestanding films up to 80 lm in thickness, high geometrical precision and material purity can be deposited by DC magnetron sputtering from unheated NiTiX alloy targets. This opens up new possibilities in designing next generations of miniaturized Nitinol devices, in particular for medical but also for other industrial applications [8][9][10]. The versatility of micro-system technology processes further allows for integrating additional features to the Nitinol structures, such as X-ray markers [11], micro-electrodes [12], and other sensors.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Freestanding NiTi Based Thin Film Materials for Shape Memory Micro-actuator Applications

Bechtold¹,

Chluba²,

Zamponi

et al. 2019

Shap. Mem. Superelasticity

View full text Add to dashboard Cite

Thin film shape memory actuators fabricated by micro-system technology processes are of particular interest in micro-actuator applications due to their high work output, large displacements, and a comparably easy and compact system setup. Micro-system technology processes allow to deposit and structure ultra-precise parts from a wide range of alloys, among them alloys that are difficult to process with conventional fabrication techniques. However, sputtered NiTi based thin films are seldom deposited with thicknesses [ 10 lm, which limits their range of application as well as makes the handling of freestanding films difficult. In this work, freestanding NiTi, NiTiCu, and NiTiHf shape memory structures were fabricated by means of sputtering, lithography, and wet etching, with a process that allows for thicknesses up to 80 lm. Their high cycle actuation behavior and microstructure were characterized. NiTiCu actuators show an excellent cyclic stability, resulting in high fatigue lives of [ 10 8 cycles at 1.5% strain, even for stresses as high as 550 MPa. A distinct martensite/austenite interface is observed during transformation, in contrast to NiTi exhibiting a rather homogeneous transformation during heating and cooling throughout the sample volume. Sputtered NiTiHf actuators tested in air can reach fatigue lives as high as 1.5 9 10 6 cycles at 1% strain. Keywords NiTi Á NiTiHf Á Mechanical behavior Á Shape memory films Á Thermal cycling This article is an invited submission to Shape Memory and Superelasticity selected from presentations at the Shape Memory and Superelastic Technology Conference and Exposition (SMST2019) held May 13-17, 2019 at The Bodensee Forum in Konstanz, Germany, and has been expanded from the original presentation.

show abstract

Microstructured Nickel-Titanium Thin Film Leaflets for Hybrid Tissue Engineered Heart Valves Fabricated by Magnetron Sputter Deposition

Cited by 10 publications

References 21 publications

Biomaterials in Valvular Heart Diseases

Biomaterials in Valvular Heart Diseases

Corrosion Behavior and In Vitro Cytotoxicity of Ni–Ti and Stainless Steel Arch Wires Exposed to Lysozyme, Ovalbumin, and Bovine Serum Albumin

Fabrication and Characterization of Freestanding NiTi Based Thin Film Materials for Shape Memory Micro-actuator Applications

Contact Info

Product

Resources

About