Microstructure of Dispersed Colloidal Particles of a Bilayer Cubic Phase

Zheng, Li Qiang; Um, Jung Yoon; Chung, Heesun; Kwon, Ick Chan; Li, Gan Zuo; Jeong, Seo Young

doi:10.1081/dis-120017951

Cited by 7 publications

(5 citation statements)

References 14 publications

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“…There is concern that the high energy input associated with these processing methods can damage the internal nanoparticle structure and active agents that may be encapsulated in the nanoparticles in relation to certain applications. Many techniques are based on precursor formulations where certain additives, such as ethanol 56 and PEG-lipid conjugates, 55 cause the surfactants to form cubosomes spontaneously when diluted with water in a way such that the dilution trajectory crosses a cubic phase region of the phase diagram. Spray-dried cubosome precursor powders have also been prepared.…”

Section: Preparation Of Nanoparticle Dispersionsmentioning

confidence: 99%

Ordered 2-D and 3-D nanostructured amphiphile self-assembly materials stable in excess solvent

Kaasgaard

Drummond

2006

Phys. Chem. Chem. Phys.

246

241

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Amphiphile lyotropic liquid crystalline self-assembly materials are being used for a diverse range of applications. Historically, the most studied lyotropic liquid crystalline phase is probably the one-dimensional (1-D) lamellar phase, which has been employed as a model system for biomembranes and for drug delivery applications. In recent years, the structurally more complex 2-D and 3-D ordered lyotropic liquid crystalline phases, of which reversed hexagonal (H(2)) and reversed cubic phases (v(2)) are two prominent examples, have received growing interest. As is the case for the lamellar phase, these phases are frequently stable in excess water, which facilitates the preparation of nanoparticle dispersions and makes them suitable candidates for the encapsulation and controlled release of drugs. Integral membrane protein crystallization media and templates for the synthesis of inorganic nanostructured materials are other applications for 2-D and 3-D amphiphile self-assembly materials. The number of amphiphiles identified as forming nanostructured reversed phases stable in excess solvent is rapidly growing. In this article, different classes of amphiphiles that form reversed phases in excess solvent are reviewed, with an emphasis on linking phase behavior to amphiphile structure. The different amphiphile classes include: ethylene oxide-, monoacylglycerol-, glycolipid-, phosphatidylethanolamine-, and urea-based amphiphiles.

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Section: Preparation Of Nanoparticle Dispersionsmentioning

confidence: 99%

Ordered 2-D and 3-D nanostructured amphiphile self-assembly materials stable in excess solvent

Kaasgaard

Drummond

2006

Phys. Chem. Chem. Phys.

246

241

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“…Mixtures of liquid crystal forming lipid in ethanol or other organic solvents (liquid precursors) are dispersed in excess water (or the solvent of choice) resulting in the spontaneous formation of cubosomes (Rizwan et al 2011 ;Spicer et al 2001 ;Zheng et al 2003 ;Chung et al 2002 ).…”

Section: Production Of Cubosomesmentioning

confidence: 99%

Cubosomes: Structure, Preparation and Use as an Antigen Delivery System

Rizwan

Boyd

2014

Advances in Delivery Science and Technology

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“…Bei Zugabe von Europiumionen (Eu 3+ ) wurde eine Verschiebung des Signals des Carbonylkohlenstoffatoms der [1‐ 13 C]Ölsäure, die dem Lipidaggregat beigemischt wurde, beobachtet. Stationäre Fluoreszenzspektroskopiemessungen legen die Existenz zweier getrennter, Wasser enthaltender Hohlräume in den kubischen Partikeln nahe: Ein Hohlraum ist verbunden mit der äußeren Wasserumgebung, der zweite ist geschlossen 29. Die kubischen Kolloidpartikel wurden in situ durch Rasterkraftmikroskopie untersucht,16 wobei eine enge Größenverteilung um 300 nm beobachtet wurde (Abbildung 8).…”

Section: Dispersionsstabilisierte Kubische Flüssigkristalline Nanounclassified

Kubische flüssigkristalline Nanopartikel

Armitage

Marder

2004

Angewandte Chemie

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Kubische flüssigkristalline Nanopartikel, die aus wässrigen Dispersionen kubischer Lipid‐Wasser‐Phasen hergestellt werden, sind bei Anwesenheit bestimmter Dispersionsmittel kinetisch stabil. Die Eigenschaften kubischer Nanopartikel aus Monoolein‐Wasser‐ und anderen Lipid‐Wasser‐Systemen wurden mit verschiedenen experimentellen Techniken untersucht. Die kubischen Nanopartikel können durch die Polymerisation reaktiver Lipide in den kubischen Lipidsystemen stabilisiert werden. Zur einfacheren Herstellung und Anwendung kubischer Nanopartikel wurden verschiedene energiesparende Methoden entwickelt. Kubische Nanoparkikel sind wegen ihrer Fähigkeit, lipophile, amphiphile und hydrophile Moleküle gesteuert aufzunehmen und abzugeben, sowie ihrer guten Biokompatibilität hervorragende Kandidaten für die Anwendung beim Transport von Wirkstoffen.

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Microstructure of Dispersed Colloidal Particles of a Bilayer Cubic Phase

Cited by 7 publications

References 14 publications

Ordered 2-D and 3-D nanostructured amphiphile self-assembly materials stable in excess solvent

Ordered 2-D and 3-D nanostructured amphiphile self-assembly materials stable in excess solvent

Cubosomes: Structure, Preparation and Use as an Antigen Delivery System

Kubische flüssigkristalline Nanopartikel

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