Microstructure, mechanical properties and bio-corrosion evaluation of biodegradable AZ91-FA nanocomposites for biomedical applications

Razavi, Mehdi; Fathi, Mohammadhossein; Meratian, Mahmood

doi:10.1016/j.msea.2010.07.063

Cited by 150 publications

(61 citation statements)

References 24 publications

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“…19 Since biodegradable or bioresorbable implants with sufficient tenacity are crucial, study for biodegradable metals such as Mg and Mg alloys are increasing. 20 Ping Lua 21 with colleagues reported controllable biodegradability PTX-eluting magnesium stents by fabricating a micro-arc-oxidation/poly-l-lactic acid composite coating on the magnesium alloy AZ81 substrate. However, this kind of magnesium alloy, such as AZ91 and AZ81, contain several percents of Al, whose ions may cause Alzheimer's disease.…”

mentioning

confidence: 99%

Electrochemical Deposition of Cisplatin on Pure Magnesium

Lai

Lin

Hsu

et al. 2018

J. Electrochem. Soc.

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In this research, the cisplatin has been successfully deposited on pure Mg specimen, degradable and promising for the tumor treatment by its local sustained release to prevent the cancer from metastasis and even to achieve its apoptosis. The cathodic polarization tests coupled with electrochemical reactions in various concentrations of cisplatin solutions were qualitatively and quantitatively analyzed to speculate the deposition mechanism of cisplatin by UV visible spectrometer, Fourier transform infrared spectroscopy, field emission scanning electron microscope coupled with energy-dispersive spectroscopy, focused ion beam, and X-ray diffractometer. The drug, cisplatin, is deposited on the pure Mg through exchanging Cl − with OH − , produced by the electrochemical method, to form strong hydrogen bonds for attracting one another. The FESEM images of cisplatin coated Mg specimens reveal that the diameter of cisplatin particle is around 50-150 nm with sphere-like shape. While that on cisplatin/HAp composite is less than 30 nm. Due to the high porosity, the drug loading on cisplatin/HAp coated one can be enhanced from 34.65 to 84.93 μg/cm 2 . Also, the drug release duration can be elongated from one day burst to 3 weeks sustained release, which is promising for future clinical applications. There are many ways to treat cancer, including surgery, chemotherapy, radiotherapy, targeted therapy and so on. Among all these therapeutic methods, the conventional drug administration method, chemotherapy, is an indispensable choice for its high efficiency. Though widely utilized, it causes severe complications. In fact, chemotherapy affects people systemically, which kills not only tumor cells but also normal cells like immune cells. In many situations, people can't help but stop chemotherapy treatment before cancer cells eradicated due to severe side effects including mouth sores, hypersensitivity reactions, nausea, vomiting, diarrhea, low blood counts and hair loss.1 Current development of carriers to release drugs locally at controlled rate, which are more specific and safe due to dramatic reducing the side effects, are interesting and spotlighted. 2-5Over the last 40 years, platinum-based drugs become the significant medicines for cancer therapy, approximately half of cancer patients undergo platinum-based drugs chemotherapeutic treatment. Cisplatin and carboplatin are two major platinum-based drugs used in chemotherapy.5 Cis-diamminedichloroplatinum (II) (CDDP), commonly called cisplatin, is the first anticancer drug, which was discovered in 1965 and approved for clinical use in 1978. 6 It is the preferred medicine for a variety of solid tumors, such as testicular and ovarian cancers, and is also used for treating bladder, cervical, esophageal, and small cell lung cancer. The success in cisplatin-based chemotherapy drugs strongly depends on how careful the drug's dosages are monitored in order to reduce severe side-effects. 5,7 This show how important the localized cancer treatment is through sustaining drug release, ac...

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confidence: 99%

Electrochemical Deposition of Cisplatin on Pure Magnesium

Lai

Lin

Hsu

et al. 2018

J. Electrochem. Soc.

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“…The density of magnesium is 1.74 g/cm 3 , which is slightly lower than natural bone (1.8e2.1 g/cm 3 ). The elastic modulus of pure Mg is 45 GPa, which is compatible to the elastic modulus of human bone, which varies from 40 to 57 GPa (Feng & Han, 2010;Razavi, Fathi, & Meratian, 2010). Hence, applications of Mg to hard-tissue engineering would greatly reduce the possibility of stress shielding, preventing bone resorption.…”

Section: Functional Coating For Biomedical Applicationsmentioning

confidence: 92%

Cold-spray coatings on magnesium and its alloys

Wang

Zhang

2015

Surface Modification of Magnesium and Its Alloys for Biomedical Applications

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“…A human organism well tolerates these alloys [362,363] mainly with coatings adapted to bioresorbable implants [364][365][366][367]. Reinforcements of magnesium MMCs usually include, notably, HA [368][369][370][371][372][373], FA [374], calcium polyphosphate [375], and calcium [374] and well affect biocompatibility. Mg and its alloys can be used for non-biodegradable scaffolds [372].…”

Section: Selection Of Materials Of Implantable Devices In Regenerativmentioning

confidence: 99%

Introductory Chapter: Multi-Aspect Bibliographic Analysis of the Synergy of Technical, Biological and Medical Sciences Concerning Materials and Technologies Used for Medical and Dental Implantable Devices

Dobrzański¹

2018

Biomaterials in Regenerative Medicine

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Microstructure, mechanical properties and bio-corrosion evaluation of biodegradable AZ91-FA nanocomposites for biomedical applications

Cited by 150 publications

References 24 publications

Electrochemical Deposition of Cisplatin on Pure Magnesium

Electrochemical Deposition of Cisplatin on Pure Magnesium

Cold-spray coatings on magnesium and its alloys

Introductory Chapter: Multi-Aspect Bibliographic Analysis of the Synergy of Technical, Biological and Medical Sciences Concerning Materials and Technologies Used for Medical and Dental Implantable Devices

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