The flow behaviors of powder metallurgy (PM) Ti‐45Al‐6Nb‐0.3W (at.%) alloy were systematically investigated in the temperature range from1050 to 1200°Cand the strain rates from 0.001 to 0.5 s−1. The effects of the temperature and the strain rate on deformation behaviors were represented by Zener–Hollomon parameter in an exponent‐type equation. Microstructural observations revealed that α2/γ lamellar colonies varied into particle α2 due to dynamic recrystallization (DRX) at high temperature during the compression. The result indicated that the strain‐dependent constitutive equation could lead to a good agreement between the calculated and measured flow stresses in the elevated temperature range for the PM Ti‐45Al‐6Nb‐0.3W alloy. Subsequently, the correlation coefficient (R) and the average absolute relative error (AARE) were introduced to verify the validity of the constitutive equation, and values of R and AARE were 0.99483 and 3.956%, respectively.