Microstructure, corrosion and tribological and antibacterial properties of Ti–Cu coated stainless steel

Jin, Xiaomin; Gao, Lizhen; Liu, Erqiang; Yu, Feifei; Shu, Xuefeng; Wang, Hefeng

doi:10.1016/j.jmbbm.2015.06.004

Cited by 58 publications

(15 citation statements)

References 44 publications

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“…SS has been coated with different ions given their antibacterial effect. Cu together with Ti were coated onto SS [44], Cu being an antibacterial agent. Ti was used to enhance the…”

Section: Prevention and Management Of Infection Of Medical Implantsmentioning

confidence: 99%

Surface modification of stainless steel for biomedical applications: Revisiting a century-old material

Bekmurzayeva

Duncanson

Azevedo

et al. 2018

Materials Science and Engineering: C

189

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Stainless steel (SS) has been widely used as a material for fabricating cardiovascular stents/valves, orthopedic prosthesis, and other devices and implants used in biomedicine due to its malleability and resistance to corrosion and fatigue. Despite its good mechanical properties, SS (as other metals) lacks biofunctionality. To be successfully used as a biomaterial, SS must be made resistant to the biological environment by increasing its anti-fouling properties, preventing biofilm formation (passive surface modification), and imparting functionality for eluting a specific drug or capturing selected cells (active surface modification); these features depend on the final application. Various physico-chemical techniques, including plasma vapor deposition, electrochemical treatment, and attachment of different linkers that add functional groups, are used to obtain SS with increased corrosion resistance, improved osseointegration capabilities, added hemocompatibility, and enhanced antibacterial properties. Existing literature on this topic is extensive and has not been covered in an integrated way in previous reviews. This review aims to fill this gap, by surveying the literature on SS surface modification methods, as well as modification routes tailored for specific biomedical applications.

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“…SS has been coated with different ions given their antibacterial effect. Cu together with Ti were coated onto SS [44], Cu being an antibacterial agent. Ti was used to enhance the…”

Section: Prevention and Management Of Infection Of Medical Implantsmentioning

confidence: 99%

Surface modification of stainless steel for biomedical applications: Revisiting a century-old material

Bekmurzayeva

Duncanson

Azevedo

et al. 2018

Materials Science and Engineering: C

189

View full text Add to dashboard Cite

show abstract

“…Clearly, the growth of S. aureus was strongly influenced by the presence of Cu. Since copper ions kill bacteria by destroying the cell wall and cell membrane, causing the cytoplasm to leak [ 21 ], it is tempting to speculate that the cell membrane difference between Gram-negative E. coli and Gram-positive S. aureus could explain why E. coli was affected less by the presence of Cu than S. aureus . This strain of E. coli has previously been shown to demonstrate less sensitivity to copper nanoparticles compared to S. aureus [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

“…To study the effect of Cu addition on the bacterial growth inhibition, a number of Ti6Al4V and Ti6Al4V (ELI)-1 at % Cu discs of 10 mm in diameter and 3 mm in height were manufactured. Antibacterial activity was tested against E. coli ATCC 10536 and S. aureus ATCC 25923 [ 8 , 19 , 20 , 21 , 22 ] as pure cultures. Each strain was revived from cryo-preservation by plating on nutrient agar and incubating at 37 °C for 24 h. Inoculums of actively growing cultures suspensions were obtained by sub-culturing in nutrient broth and dilution to 10 5 CFU/ml.…”

Section: Methodsmentioning

confidence: 99%

Functionalization of Biomedical Ti6Al4V via In Situ Alloying by Cu during Laser Powder Bed Fusion Manufacturing

et al. 2017

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The modern medical industry successfully utilizes Laser Powder Bed Fusion (LPBF) to manufacture complex custom implants. Ti6Al4V is one of the most commonly used biocompatible alloys. In surgery practice, infection at the bone–implant interface is one of the key reasons for implant failure. Therefore, advanced implants with biocompatibility and antibacterial properties are required. Modification of Ti alloy with Cu, which in small concentrations is a proven non-toxic antibacterial agent, is an attractive way to manufacture implants with embedded antibacterial functionality. The possibility of achieving alloying in situ, during manufacturing, is a unique option of the LPBF technology. It provides unique opportunities to manufacture customized implant shapes and design new alloys. Nevertheless, optimal process parameters need to be established for the in situ alloyed materials to form dense parts with required mechanical properties. This research is dedicated to an investigation of Ti6Al4V (ELI)-1 at % Cu material, manufactured by LPBF from a mixture of Ti6Al4V (ELI) and pure Cu powders. The effect of process parameters on surface roughness, chemical composition and distribution of Cu was investigated. Chemical homogeneity was discussed in relation to differences in the viscosity and density of molten Cu and Ti6Al4V. Microstructure, mechanical properties, and fracture behavior of as-built 3D samples were analyzed and discussed. Pilot antibacterial functionalization testing of Ti6Al4V (ELI) in situ alloyed with 1 at % Cu showed promising results and notable reduction in the growth of pure cultures of Escherichia coli and Staphylococcus aureus.

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“…The experimental procedure is shown in Figure 1. effect by damaging the cell wall and cell membranes of the bacteria via the strong oxidizing characteristic of the metal ions, which eventually inhibits the metabolism of the bacteria [34]. Corrosion resistance has also been the focus of recent studies, as materials used in dental implants face the unique problem of contact with fluoride ions from dental treatment products.…”

Section: Methodsmentioning

confidence: 99%

“…The addition of Cu can also enhance the antibacterial properties of a material, which has been the trend in the development of antibacterial stainless steel in recent years [32,33]. The use of metals, such as Cu and Ag, achieves an antibacterial effect by damaging the cell wall and cell membranes of the bacteria via the strong oxidizing characteristic of the metal ions, which eventually inhibits the metabolism of the bacteria [34]. Corrosion resistance has also been the focus of recent studies, as materials used in dental implants face the unique problem of contact with fluoride ions from dental treatment products.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Properties and Corrosion Resistance of the Newly Developed Biomaterial, Ti–12Nb–1Ag Alloy

Chao

Chiu

et al. 2017

Metals

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Currently, the development of biomaterials has focused on having a low Young's modulus, biocompatibility, corrosion resistance, and antibacterial properties. Ti-Nb alloys have higher research value due to their excellent corrosion resistance and low Young's modulus. In recent years, the antibacterial properties of materials have been enhanced by the addition of Ag and Cu. Therefore, the corrosion resistance and antibacterial properties of the Ti-12Nb-1Ag alloy formulated in the current study were investigated and compared to those of commonly used Ti alloys, G2 pure Ti (ASTM B348 CP Grade 2), and Ti-6Al-4V, via electrochemical and E. coli antibacterial tests. Meanwhile, we also carried out a microstructural analysis to investigate the composition of the alloy. The results were as follows: (1) The electrochemical test demonstrated that Ti-12Nb-1Ag had a higher corrosion resistance than Ti-6Al-4V, which is similar to the properties of pure Ti. (2) The E. coli antibacterial test demonstrated that the sterilization rate of Ti-12Nb-1Ag was higher than that of the Ti-6Al-4V alloy and pure Ti. (3) The microstructural analysis revealed that Ti-12Nb-1Ag had an acicular martensite structure, with nano-Ag precipitates observed. Based on the results of the E. coli antibacterial test and the principles of sterilization of nano-precipitates and Ag, we inferred that the nano-Ag precipitates of Ti-12Nb-1Ag enhanced the antibacterial properties of the newly developed biomaterial, which is, namely, the Ti-12Nb-1Ag alloy.

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Microstructure, corrosion and tribological and antibacterial properties of Ti–Cu coated stainless steel

Cited by 58 publications

References 44 publications

Surface modification of stainless steel for biomedical applications: Revisiting a century-old material

Surface modification of stainless steel for biomedical applications: Revisiting a century-old material

Functionalization of Biomedical Ti6Al4V via In Situ Alloying by Cu during Laser Powder Bed Fusion Manufacturing

Antibacterial Properties and Corrosion Resistance of the Newly Developed Biomaterial, Ti–12Nb–1Ag Alloy

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