Microstructure-based non-Fourier heat transfer modeling of HIFU treatment for thyroid cancer

Namakshenas, Pouya; Mojra, Afsaneh

doi:10.1016/j.cmpb.2020.105698

Cited by 25 publications

(13 citation statements)

References 33 publications

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“…Therefore, an auxiliary concept is needed to damage the cells in central areas. High-intensity focused ultrasound (HIFU) is a non-invasive thermal procedure that can raise the temperature of the tumor center using focused ultrasound waves to such an extent that the central areas become irreversibly necrotic 23 – 25 . However, poor control of temperature, thermal dose, and time spans in this method have prevented clinical trials from reaching clinical endpoints.…”

Section: Introductionmentioning

confidence: 99%

Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors

Souri

Soltani

Kashkooli

2021

Sci Rep

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For the first time, inspired by magnetic resonance imaging-guidance high intensity focused ultrasound (MR-HIFU) technology, i.e., medication therapy and thermal ablation in one session, in a preclinical setting based on a developed mathematical model, the performance of doxorubicin (Dox) and its encapsulation have been investigated in this study. Five different treatment methods, that combine medication therapy with mild hyperthermia by MRI contrast ($$\gamma -{Fe}_{2}{O}_{3}$$ γ - Fe 2 O 3 ) and thermal ablation via HIFU, are investigated in detail. A comparison between classical chemotherapy and thermochemistry shows that temperature can improve the therapeutic outcome by stimulating biological properties. On the other hand, the intravascular release of ThermoDox increases the concentration of free drug by 2.6 times compared to classical chemotherapy. The transport of drug in interstitium relies mainly on the diffusion mechanism to be able to penetrate deeper and reach the cancer cells in the inner regions of the tumor. Due to the low drug penetration into the tumor center, thermal ablation has been used for necrosis of the central areas before thermochemotherapy and ThermoDox therapy. Perfusion of the region around the necrotic zone is found to be damaged, while cells in the region are alive and not affected by medication therapy; so, there is a risk of tumor recurrence. Therefore, it is recommended that ablation be performed after the medication therapy. Our model describes a comprehensive assessment of MR-HIFU technology, taking into account many effective details, which can be a reliable guide towards the optimal use of drug delivery systems.

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Section: Introductionmentioning

confidence: 99%

Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors

Souri

Soltani

Kashkooli

2021

Sci Rep

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“…In fact, when Eqs. (8) and (9) were combined the perfusion term disappeared. Note that in this case local thermal equilibrium should be a good approximation for temperature distributions because of the small size of the vessels considered (as described in 2,7,22 ), while this assumption would not be valid in the presence of larger vessels.…”

Section: Methodsmentioning

confidence: 99%

“…The second term on the right side of Eqs. (8) and (9) describes the interfacial convective heat transfer between blood and tissue phases across the vascular wall as defined by Newton's cooling law. Note that the Pennes' model does not consider any advective term such as the second term on the left side of Eq.…”

Section: Methodsmentioning

confidence: 99%

“…However, when the local thermal equilibrium hypothesis is maintained, tissue and blood are really at the same temperature, so that T t = T b = T and Eqs. (8) and (9) can be combined in a single equation as follows:…”

Section: Methodsmentioning

confidence: 99%

“…Our motive for this study was that more realistic models based on porous media could predict tissue temperature more accurately, especially in highly porous organs such as the liver 6 . In addition, since the porous media theory includes fewer assumptions than other bioheat equations, it is reasonable to think that it is more suitable for treating heat transfer in biological tissues 5,[7][8][9][10][11] . In fact in the models based on porous media, tissue and blood temperatures are calculated separately, ignoring Pennes' assumption of uniform 37 ºC blood temperature throughout the tissue, which is unrealistic in thermal ablation, where tissue temperatures can go beyond 100 °C near the probe.…”

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confidence: 99%

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Pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation

Tucci

Trujillo

Berjano

et al. 2021

Sci Rep

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The objective of this study was to compare three different heat transfer models for radiofrequency ablation of in vivo liver tissue using a cooled electrode and three different voltage levels. The comparison was between the simplest but less realistic Pennes’ equation and two porous media-based models, i.e. the Local Thermal Non-Equilibrium (LTNE) equations and Local Thermal Equilibrium (LTE) equation, both modified to take into account two-phase water vaporization (tissue and blood). Different blood volume fractions in liver were considered and the blood velocity was modeled to simulate a vascular network. Governing equations with the appropriate boundary conditions were solved with Comsol Multiphysics finite-element code. The results in terms of coagulation transverse diameters and temperature distributions at the end of the application showed significant differences, especially between Pennes and the modified LTNE and LTE models. The new modified porous media-based models covered the ranges found in the few in vivo experimental studies in the literature and they were closer to the published results with similar in vivo protocol. The outcomes highlight the importance of considering the three models in the future in order to improve thermal ablation protocols and devices and adapt the model to different organs and patient profiles.

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Phase-Lag Models

Zhmakin

2023

Non-Fourier Heat Conduction

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Microstructure-based non-Fourier heat transfer modeling of HIFU treatment for thyroid cancer

Cited by 25 publications

References 33 publications

Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors

Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors

Pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation

Phase-Lag Models

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