Microstructure and Phase Transformation of Biomedical Ti–20Nb–12Ta–0.5Zr Alloys Fabricated by Selective Laser Melting

Additively Manufactured Tantalum Implants for Repairing Bone Defects: A Systematic Review

“…For comprehensive analysis, the included articles were assigned into the following three groups (Fig. 4e): physicochemical studies, 33,37,40-42,44,45,47,48,51-54 biological research, 12,17,18,31,32,34,36,38,39,43,46,49 and clinical application. 35,50 The first group included three subgroups, namely basic physical properties, 40,44,48 material modification, 33,41,42,45,47,54 and processing parameter analysis.…”

“…37,[51][52][53] The second group contained two subgroups namely basic biological properties 12,17,32,36,46 and implant modification. 18,31,34,38,39,43,49 The last group included a case report 50 and a prospective clinical study. 35…”

“…63 Combination with Ta enhanced the cell-biomaterial interactions of inherently bioinert metallic implants without sacrificing mechanical properties, which have become a new focus of attention. 18,31,34,38,39,43,49 The combination of Ti and Ta was studied most widely for improved FIG. 7.…”

“…The growth of cells on Ti-80%Ta was similar to that on pure Ta, which may be due to the existence of pure Ta particles on the surface of Ti-80%Ta. 39 Material modification based on Ti-Ta-Nb was also considered 43,49 ; Razavi et al proved that the Ti-35.5Nb-5.7Ta alloy showed considerable biocompatibility with HEK293T in cell adhesion or cytotoxicity. 43 In vivo experiments also illustrated that Ti-20Nb-12Ta-0.5zr alloy promoted bone formation.…”