Ferritic/martensitic steels based on the Fe-Cr system are attractive for nuclear engineering applications due to high strength, low swelling, and good thermal stability. [1] Additional capacity to enhance the radiation tolerance together with mechanical performance of engineering alloys can be realized by microstructure design via different approaches to increase the density of internal sinks for radiation-induced point defects. [2,3] Nanostructuring techniques based on severe plastic deformation are able to produce bulk fine-grained samples of metals and alloys with enhanced multifunctional properties (strength, conductivity, biocompatibility, corrosion resistance, shape memory effect, fatigue properties, and so on), [4] which makes them attractive for innovative applications (for medicine, energy, automotive industries, and so on), [5] in particular, for those requiring advanced materials with elevated radiation tolerance. [3] The aim of this work was to explore the potentiality of this approach to expand the limits of radiation tolerance enhancement of steels of the Fe-Cr system. Recently, we showed that in a model Fe-Cr-W alloy, it is possible to reduce grain size down to about 100 nm using severe plastic deformation by high-pressure torsion, which resulted in a significant enhancement of mechanical performance. [6] One may then expect that such microstructure refinement would also improve the radiation tolerance due to the enhanced defect annihilation rate provided by the drastically increased number of grain boundaries. This is an important task for the alloys of a Fe-Cr system because Cr is known to suppress swelling and at the same time to increase the defect accumulation rate induced by irradiation [7] that provides high radiation strengthening together with significant reduction in ductility of irradiated alloys down to embrittlement at high Cr concentration (18 wt%). [8] This article features the results of a study undertaken to evaluate the effect of ion irradiation in a Fe-14Cr-1W (wt%) steel with different grain sizes. As it has been already reported in our previous publication, [6] high-pressure torsion (HPT) of a Fe-14Cr-1W steel with an initial grain size of 5 μm provided severe microstructure refinement to a mean grain size of 110 nm with an aspect ratio of about 2 (165 Â 70 nm). The fraction of low-angle grain boundaries did not exceed 20%. As a result, the mechanical performance was dramatically enhanced. The microhardness was notably increased (from 230 to 640 Hv); the yield stress changed from 270 to 1670 MPa and ultimate tensile stress from 530 to 1885 MPa. [6] In frames of this study, the same two states of Fe-Cr-W steel with different grain sizes were subjected to self-ion irradiation to a damage dose of 10 dpa at a temperature of 400 C. Following the research by Aydogan et al., [9] it is critical to ensure the stability of microstructure under irradiation conditions; otherwise recovery processes of the nanostructured state would interfere with accumulation of point defects and lead to fa...