Microstructure and mechanical and corrosion properties of hot-extruded Mg–Zn–Ca–(Mn) biodegradable alloys

Баженов, В. Е.; Li, A.V.; Комиссаров, А. А.; Колтыгин, А. В.; Tavolzhanskii, S. A.; Bautin, V. A.; Voropaeva, O.O.; Mukhametshina, Aigul; Tokar, A. A.

doi:10.1016/j.jma.2020.11.008

Cited by 65 publications

(21 citation statements)

References 61 publications

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“…Alloying of various biocompatible elements into magnesium has been shown to improve the biocorrosion resistance [25][26][27]. From a biosafety perspective, the addition of endogenous alloying elements is a viable option that can, in addition, assist in circumventing the issue of host rejection [28][29][30].…”

Section: Introductionmentioning

confidence: 99%

“…Manganese (Mn) is an essential trace element for physiological processes, and it is a necessary element for the immune system and a variety of enzymes [42,43]. Mn addition reduces the grain size thereby enhancing grain refinement [26,27]. The addition of Mn forms alpha Mn precipitates which hinders the growth of grains during the process of extrusion.…”

Section: Introductionmentioning

confidence: 99%

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Compositional Tailoring of Mg–2Zn–1Ca Alloy Using Manganese to Enhance Compression Response and In-Vitro Degradation

et al. 2022

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The present study investigates Mg–2Zn–1Ca/XMn alloys as biodegradable implants for orthopedic fracture fixation applications. The effect of the presence and progressive addition of manganese (X = 0.3, 0.5, and 0.7 wt.%) on the degradation, and post-corrosion compressive response were investigated. Results suggest that the addition of manganese at 0.5 wt.% improved the corrosion resistance of Mg–2Zn–1Ca alloys. The pH values stabilized for the 0.5Mn-containing alloy and displayed a lower corrosion rate when compared to other Mg–2Zn–1Ca/Mn alloys. Mg–2Zn–1Ca showed a progressive reduction in the compressive strength properties at the end of day 21 whereas Mg–2Zn–1Ca/0.3Mn and Mg–2Zn–1Ca/0.5Mn samples showed a decrease until day 14 and stabilized around the same strength range after day 21. The ability of Mg–2Zn–1Ca/0.5Mn alloy to develop a network of protective hydroxide and phosphate layers has resulted in the corrosion control of the alloy. Mg–2Zn–1Ca/0.7Mn displays segregation of Mn particles at the grain boundaries resulting in decreased corrosion protection. The mechanism behind the corrosion protection of Mg–2Zn–1Ca alloys was discussed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Compositional Tailoring of Mg–2Zn–1Ca Alloy Using Manganese to Enhance Compression Response and In-Vitro Degradation

et al. 2022

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“…Manganese (Mn) is an essential trace element for physiological processes, and it is a necessary element for the immune system and a variety of enzymes 31 , 32 . Mn addition reduces the grain size thereby enhancing grain refinement 33 , 34 . Addition of Mn forms alpha Mn precipitates which hinders the growth of grains during the process of extrusion.…”

Section: Introductionmentioning

confidence: 99%

In vitro cytotoxicity and osteogenic potential of quaternary Mg-2Zn-1Ca/X-Mn alloys for craniofacial reconstruction

Prasadh

Gupta

Wong

2022

Sci Rep

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Cytotoxicity of any biomedical material needs to be investigated for successful application within the human tissues. In this study, manganese in low amounts of 0.3, 0.5 and 0.7 (wt.%) was added to Mg2Zn1Ca alloy using Disintegrated Melt Deposition (DMD) followed by hot extrusion and the extruded alloys were tested for in vitro cytocompatibility using cell viability assays (CCK-8, LDH enzyme release assay, cell cytoskeleton and cell morphology) and in vitro osteogenic potential was evaluated using ALP, Alizarin Red and RT-PCR assays. Addition of manganese improved the cell viability and osteogenic potential in variable concentrations. The Mg2Zn1Ca /0.3 Mn and Mg2Zn1Ca /0.5 Mn alloys showed increased cell viability percentage compared to Mg2Zn1Ca alloys. The cytotoxicity percentage at the end of 24 h culture for Mg2Zn1Ca /0.3 Mn alloys showed lesser cytotoxicity percentage (~ 8%) when compared to the Mg2Zn1Ca /0.5 Mn (~ 13%) and Mg2Zn1Ca /0.7 Mn (~ 16%) samples. All the alloys showed good initial cell attachment, osteogenic potential and cell spreading. The results of this study validates great potential of Mg2Zn1Ca alloys with manganese addition and exhibited great potential for to be used as temporary implant materials in craniofacial reconstruction.

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Section: Introductionmentioning

confidence: 99%

“…Manganese (Mn) is a beneficial element for improving the corrosion resistance of Mg alloys [ 15 , 16 , 17 , 18 ]. Studies have shown that Mn addition resulted in forming a MnO 2 film on the surface of Mg alloys, inhibiting the permeation of chloride ions and improving corrosion resistance [ 17 , 18 ]. Zinc (Zn) is one of the most essential elements for the physiological functions of the human body [ 2 ], but Zn accelerates the corrosion rate because of forming the Mg x Zn y phase [ 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of the Ca2Mg6Zn3 Phase on the Corrosion Behavior of Biodegradable Mg-4.0Zn-0.2Mn-xCa Alloys in Hank’s Solution

Liu

et al. 2022

Materials

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The effect of the Ca2Mg6Zn3 phase on the corrosion behavior of biodegradable Mg-4.0Zn-0.2Mn-xCa (ZM-xCa, x = 0.1, 0.3, 0.5 and 1.0 wt.%) alloys in Hank’s solution was investigated with respect to phase spacing, morphology, distribution and volume fraction. With the increase in Ca addition, the volume fraction of the Ca2Mg6Zn3 phase increased from 2.5% to 7.6%, while its spacing declined monotonically from 43 μm to 30 μm. The Volta potentials of secondary phases relative to the Mg matrix were measured by using scanning kelvin probe force microscopy (SKPFM). The results show that the Volta potential of the intragranular spherical Ca2Mg6Zn3 phase (+109 mV) was higher than that of the dendritic Ca2Mg6Zn3 phase (+80 mV). It is suggested that the Ca2Mg6Zn3 acted as a cathode to accelerate the corrosion process due to the micro-galvanic effect. The corrosion preferred to occur around the spherical Ca2Mg6Zn3 phase at the early stage and developed into the intragranular region. The corrosion rate increased slightly with increasing Ca content from 0.1 wt.% to 0.5 wt.% because of the enhanced micro-galvanic corrosion effect. The decrease in the phase spacing and sharp increase in the secondary phase content resulted in a dramatic increase in the corrosion rate of the ZM-1.0Ca alloy.

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Microstructure and mechanical and corrosion properties of hot-extruded Mg–Zn–Ca–(Mn) biodegradable alloys

Cited by 65 publications

References 61 publications

Compositional Tailoring of Mg–2Zn–1Ca Alloy Using Manganese to Enhance Compression Response and In-Vitro Degradation

Compositional Tailoring of Mg–2Zn–1Ca Alloy Using Manganese to Enhance Compression Response and In-Vitro Degradation

In vitro cytotoxicity and osteogenic potential of quaternary Mg-2Zn-1Ca/X-Mn alloys for craniofacial reconstruction

Effect of the Ca2Mg6Zn3 Phase on the Corrosion Behavior of Biodegradable Mg-4.0Zn-0.2Mn-xCa Alloys in Hank’s Solution

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