2017
DOI: 10.1016/j.yebeh.2017.08.031
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Microstructural white matter changes and their relation to neuropsychological deficits in patients with juvenile myoclonic epilepsy

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Cited by 13 publications
(11 citation statements)
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“…Our TBSS findings indicate an involvement of large parts of the WM, predominantly comprising structures of the bilateral longitudinal fasciculus (SLF), the cortico-thalamic (corona radiata), and cortico-spinal (CST) connections, which are known to be linked with the precuneus. Conclusively, in addition to the previously described relation of widespread microstructural abnormalities and cognitive and personality characteristics in JME patients ( 28 ), our findings may lead to the hypothesis that the precuneus is part a widespread network and thereby involved in both cognitive characteristics and generalized spike-wave discharges in JME patients.…”
Section: Discussionsupporting
confidence: 80%
“…Our TBSS findings indicate an involvement of large parts of the WM, predominantly comprising structures of the bilateral longitudinal fasciculus (SLF), the cortico-thalamic (corona radiata), and cortico-spinal (CST) connections, which are known to be linked with the precuneus. Conclusively, in addition to the previously described relation of widespread microstructural abnormalities and cognitive and personality characteristics in JME patients ( 28 ), our findings may lead to the hypothesis that the precuneus is part a widespread network and thereby involved in both cognitive characteristics and generalized spike-wave discharges in JME patients.…”
Section: Discussionsupporting
confidence: 80%
“…Most studies focused on white matter tracts given the extensive axonal myelination in this area of the brain. Diffusion tensor imaging (DTI) studies have frequently been performed in patients with IGE and suggested a potential relationship between altered diffusion properties of white matter tracts and abnormal white matter myelination (Liu et al ., 2011; Focke et al ., 2014; Qiu et al ., 2016; Knake et al ., 2017). There is evidence to suggest that diffusion scalar metrics are sensitive to myelin content (Chang et al ., 2017; Zhou et al ., 2020; Lazari and Lipp, 2021).…”
Section: Discussionmentioning
confidence: 99%
“…Another study investigating alterations in cortical morphology in patients with JME has revealed thinning of the cortical thickness in multiple regions, including the postcentral, lingual, orbitofrontal, inferior temporal, and occipital cortices [5]. Additionally, a diffusion tensor imaging study identified widespread white matter microstructural abnormalities in patients with JME in numerous regions, including the corpus callosum, cingulate gyrus, frontal white matter, and anterior parts of the thalamus [6].…”
Section: Introductionmentioning
confidence: 99%