Microstructural White Matter Alterations in Mild Cognitive Impairment and Alzheimer’s Disease

Fu, Xiuwei; Shrestha, Susan; Sun, Miao; Wu, Qiaoling; Luo, Yuan; Zhang, Xianchang; Yin, Jianzhong; Ni, Hongbo

doi:10.1007/s00062-019-00805-0

Cited by 56 publications

(48 citation statements)

References 28 publications

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“…Most of previous studies of NODDI findings in AD have focused on white matter changes, 15,40,41 or specific regions of the cortex 16 . These studies reported reductions in both the NDI and ODI in regions related to AD, 15,16,40,41 and NDI in several cortical areas showed positive correlations with the MMSE, 16 which is compatible with the present results (Figure 1‐C, D and Figures 4–5). A more recent study revealed broader reduction of the NDI and ODI mainly in bilateral temporal lobes in AD 42 .…”

Section: Discussionsupporting

confidence: 91%

Association between neurite metrics and tau/inflammatory pathology in Alzheimer's disease

Sone

Shigemoto

Ogawa

et al. 2020

Alzheimer's & Dementia: Diagnosis, Assessment &

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Introduction The molecular mechanism of neurodegeneration, including tau and neurite complexity, is an important topic in Alzheimer's disease (AD) research. Methods We recruited 27 amyloid‐positive individuals identified through 11 C‐Pittsburgh compound B (PiB) positron emission tomography (PET) and 31 amyloid‐negative individuals with normal cognition. All participants underwent 11 C‐PiB and 18 F‐THK5351 PET and magnetic resonance imaging (MRI) with neurite orientation dispersion and density imaging (NODDI) protocol. The neurite density index (NDI), orientation dispersion index (ODI), and PET images were analyzed to calculate voxel‐wise correlations among the imaging modalities and correlations with cognitions. Results In the amyloid‐positive participants, there were significant negative correlations between 18 F‐THK5351 and NDI and between 18 F‐THK5351 and ODI. The bilateral mesial and lateral temporal lobes were mainly involved. Regarding cognition, 18 F‐THK5351 showed more marked associations with all cognitive domains than the other modalities. Discussion Tau and neuroinflammation in AD may reduce the neurite density and orientation dispersion, particularly in the mesial and lateral temporal lobes.

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Section: Discussionsupporting

confidence: 91%

Association between neurite metrics and tau/inflammatory pathology in Alzheimer's disease

Sone

Shigemoto

Ogawa

et al. 2020

Alzheimer's & Dementia: Diagnosis, Assessment &

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“…Assess the characteristics of neurite angular variation of extra-neurite space as well as cell membranes, somas, glial cells, and fiber orientations in white matter (20,21).…”

Section: Orientation Dispersion Index (Odi)mentioning

confidence: 99%

Association Between Proteomic Blood Biomarkers and DTI/NODDI Metrics in Adolescent Football Players: A Pilot Study

et al. 2020

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While neuroimaging and blood biomarker have been two of the most active areas of research in the neurotrauma community, these fields rarely intersect to delineate subconcussive brain injury. The aim of the study was to examine the association between diffusion MRI techniques [diffusion tensor imaging (DTI) and neurite orientation/dispersion density imaging (NODDI)] and brain-injury blood biomarker levels [tau, neurofilament-light (NfL), glial-fibrillary-acidic-protein (GFAP)] in high-school football players at their baseline, aiming to detect cumulative neuronal damage from prior seasons. Twenty-five football players were enrolled in the study. MRI measures and blood samples were obtained during preseason data collection. The whole-brain, tract-based spatial statistics was conducted for six diffusion metrics: fractional anisotropy (FA), mean diffusivity (MD), axial/radial diffusivity (AD, RD), neurite density index (NDI), and orientation dispersion index (ODI). Five players were ineligible for MRIs, and three serum samples were excluded due to hemolysis, resulting in 17 completed set of diffusion metrics and blood biomarker levels for association analysis. Our permutation-based regression model revealed that serum tau levels were significantly associated with MD and NDI in various axonal tracts; specifically, elevated serum tau levels correlated to elevated MD ( p = 0.0044) and reduced NDI ( p = 0.016) in the corpus callosum and surrounding white matter tracts (e.g., longitudinal fasciculus). Additionally, there was a negative association between NfL and ODI in the focal area of the longitudinal fasciculus. Our data suggest that high school football players may develop axonal microstructural abnormality in the corpus callosum and surrounding white matter tracts, such as longitudinal fasciculus. A future study is warranted to determine the longitudinal multimodal relationship in response to repetitive exposure to sports-related head impacts.

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“…Another study of young-onset Alzheimer's disease and NODDI reported a widespread reduction in cortical ND and OD, including mesial and lateral temporal lobe and precuneus. 18 Moreover, Fu et al 19 reported that ND has detected clearer differences between Alzheimer's disease and mild cognitive impairment than FA. Thus, NODDI may have better sensitivity to diagnose Alzheimer's disease than conventional DTI.…”

Section: Alzheimer's Diseasementioning

confidence: 99%

<p>Neurite orientation and dispersion density imaging: clinical utility, efficacy, and role in therapy</p>

Sone¹

2019

RMI

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In the field of diffusion magnetic resonance imaging (MRI) for neuroimaging, white matter tracts have traditionally been analyzed using diffusion tensor imaging (DTI) measures, such as fractional anisotropy. However, recent advances in diffusion MRI have provided further information on brain microstructures using multi-shell protocols of diffusion MRI. Neurite orientation dispersion and density imaging (NODDI) is one such emerging advanced diffusion MRI method that enables investigation of the neurite density and neurite orientation dispersion of brain microstructures. NODDI was developed as a practical and clinically feasible diffusion MRI technique to evaluate the microstructural complexity of dendrites and axons. This review shed light on recent studies on the use of NODDI in human brain. Indeed, a growing number of studies are using NODDI to examine neurological and psychiatric disorders, with most reporting its clinical utility. The time has thus come, for us to seriously consider the clinical use of NODDI.

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Microstructural White Matter Alterations in Mild Cognitive Impairment and Alzheimer’s Disease

Cited by 56 publications

References 28 publications

Association between neurite metrics and tau/inflammatory pathology in Alzheimer's disease

Association between neurite metrics and tau/inflammatory pathology in Alzheimer's disease

Association Between Proteomic Blood Biomarkers and DTI/NODDI Metrics in Adolescent Football Players: A Pilot Study

<p>Neurite orientation and dispersion density imaging: clinical utility, efficacy, and role in therapy</p>

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