Microstructural modelling of cerebral aneurysm evolution through effective stress mediated destructive remodelling

Nabaei, Malikeh; Fatouraee, Nasser

doi:10.1016/j.jtbi.2014.03.020

Cited by 13 publications

(6 citation statements)

References 37 publications

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“…When Nabaei and Fatouraee included the degradation of elastin as a function of vascular wall effective stress in their model,9 thus taking into account the shear‐dependent nature of degradation and the mural‐cell–mediated destructive activities, they found that the model was more consistent with other computational and clinical studies. Furthermore, the evolving microstructural properties of the wall during the evolution process have been better predicted by this new model.…”

Section: Discussionmentioning

confidence: 56%

Plasma Soluble Human Elastin Fragments as an Intra‐Aneurysmal Localized Biomarker for Ruptured Intracranial Aneurysm

Nakagawa

Zanaty

Hudson

et al. 2018

JAHA

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BackgroundFragmentation of the tunica media is a hallmark of intracranial aneurysm formation, often leading to aneurysmal progression and subsequent rupture. The objective of this study is to determine the plasma level of elastin fragments in the lumen of ruptured versus unruptured human intracranial aneurysms.Methods and ResultsOne hundred consecutive patients with/without ruptured saccular intracranial aneurysms undergoing endovascular coiling or stent‐assisted coiling were recruited. Blood samples were collected from the lumen of intracranial aneurysm using a microcatheter. The tip of the microcatheter was placed inside the aneurysm's sac in close proximity to the inner wall of the dome. Plasma levels of elastin fragments were measured using an ELISA‐based method. Mean plasma level of soluble human elastin fragments was significantly greater in ruptured aneurysms when compared with nonruptured aneurysms (102.0±15.5 versus 39.3±9.6 ng/mL; P<0.001). Mean plasma level of soluble human elastin fragments did not have significant correlation with age, sex, size, or aneurysm location.ConclusionsThe present study revealed that a significantly higher concentration of soluble human elastin fragments in the lumen of ruptured intracranial aneurysms when compared with nonruptured ones.

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Section: Discussionmentioning

confidence: 56%

Plasma Soluble Human Elastin Fragments as an Intra‐Aneurysmal Localized Biomarker for Ruptured Intracranial Aneurysm

Nakagawa

Zanaty

Hudson

et al. 2018

JAHA

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“…27–29 Like other computational models, the current model depends on defined assumptions as in previous flow pattern studies. 4,7,30–32 An exciting specific of the baroreflexes location is the very compliant and elastic nature of the arterial wall due to the finite collagen amount. This causes light deformation in every blood pulse.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, normal forces are controlled by the media layer's endothelium cells. [4][5][6] In addition, aneurysms and atherosclerotic plaques are vascular diseases that may be created by abnormal hemodynamic forces. 4,5,7,8 Baroreflexes are susceptible elastic receptors that control the stretch of the vessel wall and send feedback to the brain.…”

Section: Introductionmentioning

confidence: 99%

A mathematical model for biomechanical behavior of the aortic arch

2022

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The aortic arch plays a significant role in homeostatic mechanisms to retain blood pressure at stable balance in the cardiovascular system. Therefore, the objective is to estimate and identify cardiovascular illness imposed by the abnormal blood hemodynamic domain. In this regard, hemodynamic forces are monitored by the baroreflex of the artery wall. Therefore, these receptors quickly detect the abnormal stress magnitudes in the aortic arterial wall. The present study presents a 3D aortic arch model extracted by a Computerized tomography scan. Also, the numerical solution was carried out by ANSYS 2020 R1 in view of Fluid-Structure Interaction After that, we found wall shear stress (WSS), pressure, and velocity in the fluid domain. Also, the normal stress was analyzed to determine the aortic arch baroreflex location in the solid range. In this regard, higher WSS values are measured at the supra-aortic branches going out the aortic arch that reached 42.5 Pa. Also, higher normal stress happened at the aortic root and the supra-aortic branches and reached approximately 200 kPa at peak systole.

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“…, 2005; Holzapfel et al ., 2000, 2004; Mousavi et al. , 2018; Nabaei and Fatouraee, 2014; Roy et al. , 2014; Schmidt and Balzani, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…They are made of three inner, middle and outer layers, called intima, media and adventitia, respectively. Nowadays, a great attention has been paid to numerical modeling of arterial walls and corresponding diseases at the macroscale level (Balzani et al, 2012;Basciano and Kleinstreuer, 2009;Bluestein et al, 2009;Pandolfi, 2008, 2010;Gasser et al, 2005;Holzapfel et al, 2000Holzapfel et al, , 2004Mousavi et al, 2018;Nabaei and Fatouraee, 2014;Roy et al, 2014;Schmidt and Balzani, 2016). Nevertheless, there exist a few works on multiscale modeling of arterial wall problems (Nierenberger et al, 2013;Rocha et al, 2018;Speirs et al, 2008;Stylianopoulos and Barocas, 2007b).…”

Section: Introductionmentioning

confidence: 99%

3D large strain hierarchical multiscale analysis of soft fiber-reinforced tissues: application to a degraded arterial wall

Ardakani

Dehaghani

Moslemzadeh

et al. 2022

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PurposeThe purpose is to analyze the mechanical behavior of the arterial wall in the degraded region of the arterial wall and to determine the stress distribution, as an important factor for predicting the potential failure mechanisms in the wall. In fact, while the collagen fiber degradation process itself is not modeled, zones with reduced collagen fiber content (corresponding to the degradation process) are assumed. To do so, a local weakness in the media layer is considered by defining representative volume elements (RVEs) with different fiber collagen contents in the degraded area to investigate the mechanical response of the arterial wall.Design/methodology/approachA three-dimensional (3D) large strain hierarchical multiscale technique, based on the homogenization and genetic algorithm (GA), is utilized to numerically model collagen fiber degradation in a typical artery. Determination of material constants for the ground matrix and collagen fibers in the microscale level is performed by the GA. In order to investigate the mechanical degradation, two types of RVEs with different collagen contents in fibers are considered. Each RVE is divided into two parts of noncollagenous matrix and collagen fiber, and the part of collagen fiber is further divided into matrix and collagen fibrils.FindingsThe von Mises stress distributions on the inner and outer surfaces of the artery and the influence of collagen fiber degradation on thinning of the arterial wall in the degraded area are thoroughly studied. Comparing the maximum stress values on outer and inner surfaces in the degraded region shows that the inner surface is under higher stress states, which makes it more prone to failure. Furthermore, due to the weakness of the artery in the degraded area, it is concluded that the collagen fiber degradation considerably reduces the wall thickness in the degraded area, leading to an observable local inflation across the degraded artery.Originality/valueConsidering that little attention has been paid to multiscale numerical modeling of collagen fiber degradation, in this paper a 3D large strain hierarchical multiscale technique based on homogenization and GA methods is presented. Therefore, while the collagen fiber degradation process itself is not modeled in this study, zones with reduced collagen fiber content (corresponding to the degradation process) are assumed.

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Microstructural modelling of cerebral aneurysm evolution through effective stress mediated destructive remodelling

Cited by 13 publications

References 37 publications

Plasma Soluble Human Elastin Fragments as an Intra‐Aneurysmal Localized Biomarker for Ruptured Intracranial Aneurysm

Plasma Soluble Human Elastin Fragments as an Intra‐Aneurysmal Localized Biomarker for Ruptured Intracranial Aneurysm

A mathematical model for biomechanical behavior of the aortic arch

3D large strain hierarchical multiscale analysis of soft fiber-reinforced tissues: application to a degraded arterial wall

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