Microstructural, mechanical, in vitro corrosion and biological characterization of an extruded Zn-0.8Mg-0.2Sr (wt%) as an absorbable material

Čapek, Jaroslav; Kubásek, Jiří; Pinc, Jan; Fojt, Jaroslav; Krajewski, Stefanie; Rupp, Frank; Li, Ping

doi:10.1016/j.msec.2021.111924

Cited by 26 publications

(38 citation statements)

References 61 publications

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“…Minimizing the number of operations would be beneficial for the patients and could also bring significant financial savings [1,26]. As shown in our previous study [32], the mechanical and tensile strength of the investigated material fulfilled all the basic criteria for the fabrication of bone implants [45]. Magnesium alloys also have good mechanical properties [3,12], are well tolerated by bone and soft tissues [2,3], but produce gas bubbles [2,3,28], diminishing the possibilities of their practical use in human and veterinary medicine.…”

Section: Discussionmentioning

confidence: 56%

“…Magnesium alloys also have good mechanical properties [3,12], are well tolerated by bone and soft tissues [2,3], but produce gas bubbles [2,3,28], diminishing the possibilities of their practical use in human and veterinary medicine. Therefore, we have chosen a Zn-0.8Mg-0.2Sr alloy, which is known to corrode without hydrogen evolution and fulfil the basic mechanical criteria for implantology [31,32]. Moreover, this alloy was found to possess acceptable cytocompatibility in-vitro and enhanced antibacterial activity [32].…”

Section: Discussionmentioning

confidence: 99%

“…The mechanical behaviour of the investigated alloy has been studied and was discussed in our previous work [32]. It is worth mentioning that the tensile yield strength, ultimate tensile strength, ductility, and Young's modulus of the alloy were 244, 324 MPa, 20%, and 104 GPa, respectively.…”

Section: Mechanical Properties Of the Alloymentioning

confidence: 99%

“…We decided to use a Zn-Mg-Sr biodegradable alloy for our experimental rabbit study. This alloy was used because of the results that we obtained in our previous studies that described the mechanical, corrosion, and in-vitro biological behaviour of a Zn-0.8Mg-0.2Sr extruded alloy [31,32]. Those studies showed that this alloy possesses promising behaviour for application as a bone implant [31,32].…”

Section: The In-vivo Biological Behaviour Of Zn-and Mg-based Materialsmentioning

confidence: 99%

“…The annealed material was extruded at the temperature 200 • C using an extrusion ratio of 25:1. The preparation procedure is described in more detail in our previous study [32]. The exact chemical composition of the alloy was measured via atomic absorption spectroscopy (AAS) using an Agilent 280FS AA spectrometer (Agilent, Santa Clara, CA, USA) with flame atomization.…”

Section: Implant Materialsmentioning

confidence: 99%

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Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model

et al. 2021

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In this pilot study, we investigated the biocompatibility and degradation rate of an extruded Zn–0.8Mg–0.2Sr (wt.%) alloy on a rabbit model. An alloy screw was implanted into one of the tibiae of New Zealand White rabbits. After 120 days, the animals were euthanized. Evaluation included clinical assessment, microCT, histological examination of implants, analyses of the adjacent bone, and assessment of zinc, magnesium, and strontium in vital organs (liver, kidneys, brain). The bone sections with the implanted screw were examined via scanning electron microscopy and energy dispersive spectroscopy (SEM-EDS). This method showed that the implant was covered by a thin layer of phosphate-based solid corrosion products with a thickness ranging between 4 and 5 µm. Only negligible changes of the implant volume and area were observed. The degradation was not connected with gas evolution. The screws were fibrointegrated, partially osseointegrated histologically. We observed no inflammatory reaction or bone resorption. Periosteal apposition and formation of new bone with a regular structure were frequently observed near the implant surface. The histological evaluation of the liver, kidneys, and brain showed no toxic changes. The levels of Zn, Mg, and Sr after 120 days in the liver, kidneys, and brain did not exceed the reference values for these elements. The alloy was safe, biocompatible, and well-tolerated.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Mechanical Properties Of the Alloymentioning

confidence: 99%

Section: The In-vivo Biological Behaviour Of Zn-and Mg-based Materialsmentioning

confidence: 99%

Section: Implant Materialsmentioning

confidence: 99%

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Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model

et al. 2021

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Biodegradable zinc‐based materials with a polymer coating designed for biomedical applications

Oriňaková,

Gorejová,

Čákyová

et al. 2023

J of Applied Polymer Sci

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Over the last decades, biodegradable metals have gained popularity for biomedical applications due to their ability to assist in tissue healing. These materials degrade in vivo, while the corrosion products formed are either absorbed or excreted by the body, and no further surgical intervention is required for removal. Intensive research has been carried out mainly on degradable biomaterials based on Mg and Fe. In recent years, zinc‐based degradable biomaterials have been explored by the biomedical community for their intrinsic physiological relevance, desirable biocompatibility, intermediate degradation rate, tuneable mechanical properties and pro‐regeneration properties. Since pure Zn does not exhibit sufficient mechanical properties for orthopedic applications, various Zn alloys with better properties are being developed. In this work, the combined effect of minor Fe addition to Zn and a polyethyleneglycol (PEG) coating on the surface morphology, degradation, cytotoxicity and mechanical properties of Zn‐based materials was studied. There are several studies regarding the influence of the production of Zn alloys, but the effect of polymer coating on the properties of Zn‐based materials has not been reported yet. A positive effect of Fe addition and polymer coating on the degradation rate and mechanical properties was observed. However, a reduction in biocompatibility was also detected.

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Influence of Alloying Agents on the Biodegradability of Zinc

Román,

Igoa,

Ibañez

et al. 2024

The Minerals, Metals &Amp; Materials Series

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Microstructural, mechanical, in vitro corrosion and biological characterization of an extruded Zn-0.8Mg-0.2Sr (wt%) as an absorbable material

Cited by 26 publications

References 61 publications

Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model

Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model

Biodegradable zinc‐based materials with a polymer coating designed for biomedical applications

Influence of Alloying Agents on the Biodegradability of Zinc

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