Microstructural integrity of the cingulum is related to verbal memory performance in elderly with cerebral small vessel disease

Holst, Helena M. van der; Tuladhar, Anil M.; Norden, Anouk G.W. van; Laat, Karlijn F. de; Uden, Ingeborg W.M. van; Oudheusden, Lucas J.B. van; Zwiers, Marcel P.; Norris, David G.; Kessels, Roy P. C.; Leeuw, Frank Erik de

doi:10.1016/j.neuroimage.2012.09.060

Cited by 29 publications

(21 citation statements)

References 56 publications

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“…The strongest significant relations between microstructural integrity and verbal memory performance were located in the cingulum bundle. This bundle, which connects the medial temporal lobe and the posterior cingulate cortex, is an important structure in verbal memory performance ( Sepulcre et al, 2008 ; van der Holst et al, 2013 ). We also found verbal memory to be associated with the anterior parts of the corpus callosum.…”

Section: Discussionmentioning

confidence: 99%

White matter integrity in small vessel disease is related to cognition

Tuladhar

Norden

Laat

et al. 2015

NeuroImage: Clinical

148

136

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Cerebral small vessel disease, including white matter hyperintensities (WMH) and lacunes of presumed vascular origin, is common in elderly people and is related to cognitive impairment and dementia. One possible mechanism could be the disruption of white matter tracts (both within WMH and normal-appearing white matter) that connect distributed brain regions involved in cognitive functions. Here, we investigated the relation between microstructural integrity of the white matter and cognitive functions in patients with small vessel disease. The Radboud University Nijmegen Diffusion tensor and Magnetic resonance Cohort study is a prospective cohort study among 444 independently living, non-demented elderly with cerebral small vessel disease, aged between 5500 and 85 years. All subjects underwent magnetic resonance imaging and diffusion tensor imaging scanning and an extensive neuropsychological assessment. We showed that loss of microstructural integrity of the white matter at specific locations was related to specific cognitive disturbances, which was mainly located in the normal-appearing white matter (p < 0.05, FWE-corrected for multiple comparisons). The microstructural integrity in the genu and splenium showed the highest significant relation with global cognitive function and executive functions, in the cingulum bundle with verbal memory performance. Associations between diffusion tensor imaging parameters and most cognitive domains remained present after adjustment for WMH and lacunes. In conclusion, cognitive disturbances in subjects with cerebral small vessel disease are related to microstructural integrity of multiple white matter fibers (within WMH and normal-appearing white matter) connecting different cortical and subcortical regions.

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Section: Discussionmentioning

confidence: 99%

White matter integrity in small vessel disease is related to cognition

Tuladhar

Norden

Laat

et al. 2015

NeuroImage: Clinical

148

136

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“…Decoupling of PCC-MPFC connectivity during rest may reflect reorganization of functional networks, which in turn may impact the ability to coordinate DN activity during cognitive tasks. Involvement of the DN in memory and executive functioning has been demonstrated by numerous studies assessing both functional connectivity (Daselaar et al, 2004; Raichle et al, 2001; Vannini et al, 2011) and structural connectivity (Metzler-Baddeley et al, 2012; O'Sullivan et al, 2005; van der Holst et al, 2013). Due to the cross-sectional design of our study we are not able to determine whether the decoupling of structural and functional networks will predict future cognitive decline or whether the breakdown in structural and functional networks progresses at a similar rate.…”

Section: Discussionmentioning

confidence: 99%

Decoupling of structural and functional brain connectivity in older adults with white matter hyperintensities

et al. 2015

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Age-related impairments in the default network (DN) have been related to disruptions in connecting white matter tracts. We hypothesized that the local correlation between DN structural and functional connectivity is negatively affected in the presence of global white matter injury. In 125 clinically normal older adults, we tested whether the relationship between structural connectivity (via diffusion imaging tractography) and functional connectivity (via resting-state functional MRI) of the posterior cingulate cortex (PCC) and medial prefrontal frontal cortex (MPFC) of the DN was altered in the presence of white matter hyperintensities (WMH). A significant correlation was observed between microstructural properties of the cingulum bundle and MPFC-PCC functional connectivity in individuals with low WMH load, but not with high WMH load. No correlation was observed between PCC-MPFC functional connectivity and microstructure of the inferior longitudinal fasciculus, a tract not passing through the PCC or MPFC. Decoupling of connectivity, measured as the absolute difference between structural and functional connectivity, in the high WMH group was related to poorer executive functioning and memory performance. These results suggest that such decoupling may reflect reorganization of functional networks in response to global white matter pathology and may provide an early marker of clinically relevant network alterations.

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“…Fractional anisotropy is a scalar value between zero and 1 that reflects fibre density, axonal diameter and myelination in white matter, 37 and its reduction is a sign of degradation of the microstructural organization in white matter. 38 White matter changes as a consequence of small vessel disease have been linked to late-life depression 39 and have been associated with decreases in FA in specific white matter areas. 37 40 and here we demonstrated that intact areas of lesioned tracts also have lower mean FA values than intact tracts.…”

Section: Discussionmentioning

confidence: 99%

A significant risk factor for poststroke depression: the depression-related subnetwork

Yang

Hua

Shang

et al. 2015

jpn

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IntroductionPoststroke depression (PSD) is one of the most common emotional disorders afflicting those who experience stroke. A meta-analysis has indicated that the prevalence of major or mild depression is approximately 18% (range 8%-46%), 1 with the presence of PSD being associated with increased mortality.2 Converging evidence has implicated particular neural networks in the pathophysiology of mood disorders.3 However, despite being one of the direct causes of depression, whether stroke-induced neuroanatomical deterioration actually plays an important role in the onset of PSD is still controversial. Previous neuroimaging studies have focused mainly on regional differences and severity of local brain lesions. 4 In addition, an often-cited meta-analysis that reported no clear association between PSD and any specific lesion location or hemisphere 4 has fueled intense debate. Recently, although statistical parametric mapping linked affective depression to lesions centred in the left basal ganglia and left frontal cortex, the conclusions remain in doubt because results were not corrected for multiple comparisons. 5,6 Diffusion tensor imaging (DTI) is a noninvasive technique that assesses white matter connectivity, particularly fibre density and myelination. In addition, structural brain network interactions can be quantified using brain graphs 7,8 in which neuroanatomical regions are defined as a set of nodes and DTI-derived white matter connections act as interconnecting edges.7 Using this approach, a disruption of neural topology has been shown in several brain diseases, 9-11 including those occurring in chronic stroke patients. 12 Here, we evaluated 3 markers of brain-damage severity: lesion index, fractional anisotropy (FA) reduction and brain structural networks. We hypothesized that a specific brain subnetwork is associated with PSD and that the damage to it might serve as a predictor of poststroke major depression. We constructed a depression-related subnetwork based on Background: Despite being one of the direct causes of depression, whether stroke-induced neuroanatomical deterioration actually plays an important role in the onset of poststroke depression (PSD) is controversial. We assessed the structural basis of PSD, particularly with regard to white matter connectivity. Methods: We evaluated lesion index, fractional anisotropy (FA) reduction and brain structural networks and then analyzed whole brain voxel-based lesions and FA maps. To understand brain damage in the context of brain connectivity, we used a graph theoretical approach. We selected nodes whose degree correlated with the Hamilton Rating Scale for Depression score (p < 0.05, false discovery rate-corrected), after controlling for age, sex, years of education, lesion size, Mini Mental State Examination score and National Institutes of Health Stroke Scale score. We used Poisson regression with robust standard errors to assess the contribution of the identified network toward poststroke major depression. Results: We included 116 stroke patients ...

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Microstructural integrity of the cingulum is related to verbal memory performance in elderly with cerebral small vessel disease

Abstract: Microstructural integrity of the cingulum, assessed by DTI, is specifically related to verbal memory performance, in elderly with SVD. Furthermore we found that when the integrity of the hippocampus is disrupted, the cingulum integrity is impaired as well.

Cited by 29 publications

References 56 publications

White matter integrity in small vessel disease is related to cognition

White matter integrity in small vessel disease is related to cognition

Decoupling of structural and functional brain connectivity in older adults with white matter hyperintensities

A significant risk factor for poststroke depression: the depression-related subnetwork

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