[1] New structural observations coupled with 15 U/Pb and 24 Ar/Ar new ages from the Karakorum shear zone (KSZ) constrain the timing and slip rate of the right-lateral Karakorum fault zone (KFZ), one of the great continental Asian strike-slip faults. In the Tangtse-Darbuk area, the Tangtse (SW) and Muglib (NE) mylonitic strands of the KSZ frame the less deformed Pangong Range. Inherited U/Pb ages show that granitic protoliths are mostly from the Karakorum and Ladakh batoliths, with a major Miocene melting event lasting from ≥21.5 to 13.5 Ma. Some of the Miocene granitic bodies show structural evidence for intrusion synkinematic to the KSZ. The oldest of these granitoids is 18.8 AE 0.4 Ma old, implying that deformation started prior to $19 Ma. Microstructural data show that right-lateral deformation pursued during cooling. Ar/Ar data show that ductile deformation stopped earlier in the Tangtse ($11 Ma) than in the Muglib strand ($7 Ma). Deformation ended at $11 Ma in the Tangtse strand while it is still active in the Muglib strand, suggesting a progressive localization of deformation. When merged with published observations along the KFZ, these data suggest that the KFZ nucleated in the North Ayilari range at least $22 Ma ago. The long-term fault rate is 0.84 to 1.3 cm/yr, considering a total offset of 200 to 240 km. The KSZ collected magma produced within the shear zone and/or deeper in crust for which the producing mechanism stays unclear but was not the lower crustal channel flow.