Microstructural characterization of papaverine-loaded HPC/PVA gels, films and nanofibers

Kazsoki, Adrienn; Domján, Attila; Süvegh, Károly; Zelkó, Romána

doi:10.1016/j.ejps.2018.06.020

Cited by 11 publications

(11 citation statements)

References 14 publications

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“…Sufficient mucoadhesion is one of the most important criteria which a film must comply with application into the oral cavity. Typical polymers used as mucoadhesive components are gelatin, chitosan [66], pullulan [67], guar gum [68], xanthan gum [61], sodium carboxymethylcellulose [69], hydroxypropylcellulose [70] and sodium hyaluronate [71]. Various natural polysaccharides show mucoadhesive properties such as psyllium [72], okra [73] and certain rice varieties with a high amylose content [74].…”

Section: Local and Systemic Drug Deliverymentioning

confidence: 99%

“…An increased amount of permeated drug can be reached using liposomal formulations [77], nanoparticles [78], or nanofibers [70], which are gaining high impact regarding the buccal transport route [57]. Morales et al developed MBFs embedded with insulincoated nanoparticles, which resulted in an enhanced permeation of insulin through mucosa in comparison with an insulin control solution in phosphate-buffered saline [78].…”

Section: Local and Systemic Drug Deliverymentioning

confidence: 99%

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Oromucosal films: from patient centricity to production by printing techniques

Tian

Orlu

Woerdenbag

et al. 2019

Expert Opinion on Drug Delivery

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Introduction: Oromucosal films, comprising mucoadhesive buccal films (MBFs) and orodispersible films (ODFs), are considered patient-centric dosage forms. Target groups are patients with special needs. Various active pharmaceutical ingredients have been shown to be suitable for oromucosal film production. A shift is seen in the production techniques, from conventional solvent casting to printing techniques. Areas covered: In this review, the patient acceptability of oromucosal films is discussed. An overview is given of the small molecule drugs, biopharmaceuticals and herbal extracts that have been incorporated so far. Finally, the current state of 2D and 3D printing techniques for production purposes is discussed. Expert opinion: The patient-centric features are important for the further development and acceptance of this oral solid dosage form. Oromucosal films perfectly fit in the current attention for personalized medicine. Both MBFs and ODFs are intended for either a local or a systemic effect. For buccal absorption, sufficient mucoadhesion is one of the most important criteria an oromucosal film must comply with. For the preparation, the solvent casting technique is still predominately used. Some limitations of this production method can be tackled by printing techniques. However, these novel techniques introduce new requirements, yet to be set, for oromucosal film preparation.

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Section: Local and Systemic Drug Deliverymentioning

confidence: 99%

Section: Local and Systemic Drug Deliverymentioning

confidence: 99%

Oromucosal films: from patient centricity to production by printing techniques

Tian

Orlu

Woerdenbag

et al. 2019

Expert Opinion on Drug Delivery

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“…Other workers have blended PVA with other agents to try and produce membranes with improved performance characteristics. The agents include alginate [11,12], poly vinyl pyrrolidone [6], cellulose derivatives [7,11,13] collagen [14], polyethylene glycol (PEG) [10,15], chitosan [3], and latex [5]. Jodar et al [2] created blends of PEG 4000 with PVA (98% hydrolyzed) and PVA (88% hydrolyzed) followed by glutaraldehyde crosslinking.…”

Section: Introductionmentioning

confidence: 99%

The Development of Solvent Cast Films or Electrospun Nanofiber Membranes Made from Blended Poly Vinyl Alcohol Materials with Different Degrees of Hydrolyzation for Optimal Hydrogel Dissolution and Sustained Release of Anti-Infective Silver Salts

et al. 2021

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Introduction: We previously described the manufacture and characterization of hydrogel forming, thin film, anti-infective wound dressings made from Poly Vinyl Alcohol (PVA) and silver nanoparticles, crosslinked by heat. However, these films were designed to be inexpensive for simple manufacture locally in Africa. In this new study, we have further developed PVA dressings by manufacturing films or electrospun membranes, made from blends of PVA with different degrees of hydrolyzation, that contain silver salts and degrade in a controlled manner to release silver in a sustained manner over 12 days. Methods: Films were solvent cast as films or electrospun into nanofibre membranes using blends of 99 and 88% hydrolyzed PVA, containing 1% w/w silver sulphadiazine, carbonate, sulphate, or acetate salts. Dissolution was measured as weight loss in water and silver release was measured using inductively coupled plasma (ICP) analysis. Results: Cast films generally stayed intact at PVA 99: PVA 88% ratios greater than 40:60 whereas electrospun membranes needed ratios greater than 10:90. Films (40:60 blend ratio) and membranes (10:90) all released silver salts in a sustained fashion but incompletely and to different extents. Electrospun membranes gave more linear release patterns in the 2–12 day period and all salts released well. Conclusion: Blended PVA cast films offer improved control over hydrogel dissolution and silver release without the need for high temperature crosslinking. Blended PVA electrospun membranes further improve membrane dissolution control and silver release profiles. These blended PVA films and membranes offer improved inexpensive systems for the manufacture of long lasting anti-infective hydrogel wound dressings.

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“…The etherification of cellulose is an important derivatization route which yields a very broad class of derivatives with many potential applications [75]. Among many, the most frequently used ethers for the production of nanofibers are ethylcellulose [149][150][151][152][153][154], hydroxypropyl cellulose [155][156][157][158], hydroxyethyl cellulose [159][160][161][162][163], methyl cellulose [164], and carboxymethyl cellulose (CMC) [165]. The solubility of cellulose ethers is highly dependable on the degree of substitution.…”

Section: Cellulose Ethersmentioning

confidence: 99%

“…HPC is also electrospun usually alongside PVA [156][157][158] or PVP [157] to be used as a drug delivery system, as reported for diclofenac sodium [157] and papaverine hydrochloride [156].…”

Section: Cellulose Ethersmentioning

confidence: 99%

Cellulose-Based Nanofibers Processing Techniques and Methods Based on Bottom-Up Approach—A Review

Kramar

González‐Benito

2022

Polymers

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In the past decades, cellulose (one of the most important natural polymers), in the form of nanofibers, has received special attention. The nanofibrous morphology may provide exceptional properties to materials due to the high aspect ratio and dimensions in the nanometer range of the nanofibers. The first feature may lead to important consequences in mechanical behavior if there exists a particular orientation of fibers. On the other hand, nano-sizes provide a high surface-to-volume ratio, which can have important consequences on many properties, such as the wettability. There are two basic approaches for cellulose nanofibers preparation. The top-down approach implies the isolation/extraction of cellulose nanofibrils (CNFs) and nanocrystals (CNCs) from a variety of natural resources, whereby dimensions of isolates are limited by the source of cellulose and extraction procedures. The bottom-up approach can be considered in this context as the production of nanofibers using various spinning techniques, resulting in nonwoven mats or filaments. During the spinning, depending on the method and processing conditions, good control of the resulting nanofibers dimensions and, consequently, the properties of the produced materials, is possible. Pulp, cotton, and already isolated CNFs/CNCs may be used as precursors for spinning, alongside cellulose derivatives, namely esters and ethers. This review focuses on various spinning techniques to produce submicrometric fibers comprised of cellulose and cellulose derivatives. The spinning of cellulose requires the preparation of spinning solutions; therefore, an overview of various solvents is presented showing their influence on spinnability and resulting properties of nanofibers. In addition, it is shown how bottom-up spinning techniques can be used for recycling cellulose waste into new materials with added value. The application of produced cellulose fibers in various fields is also highlighted, ranging from drug delivery systems, high-strength nonwovens and filaments, filtration membranes, to biomedical scaffolds.

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Microstructural characterization of papaverine-loaded HPC/PVA gels, films and nanofibers

Cited by 11 publications

References 14 publications

Oromucosal films: from patient centricity to production by printing techniques

Oromucosal films: from patient centricity to production by printing techniques

The Development of Solvent Cast Films or Electrospun Nanofiber Membranes Made from Blended Poly Vinyl Alcohol Materials with Different Degrees of Hydrolyzation for Optimal Hydrogel Dissolution and Sustained Release of Anti-Infective Silver Salts

Cellulose-Based Nanofibers Processing Techniques and Methods Based on Bottom-Up Approach—A Review

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