Microstructural changes of whole brain in patients with comitant strabismus: evidence from a diffusion tensor imaging study

Huang, Xin; Li, Haijun; Zhang, Ying; Peng, Dechang; Hu, Pei-Hong; Zhong, Yang; Zhou, Fuqing; Shao, Yi

doi:10.2147/ndt.s108834

Cited by 24 publications

(25 citation statements)

References 33 publications

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“…In a study of anisometropic amblyopia, Liang et al (39) reported decreased amplitude of low-frequency fluctuation values in the bilateral precuneus cortex in adults with anisometropic amblyopia, and the degree of reduction was associated with disease severity, suggesting that patients with bilateral precuneus neurons exhibited weaker activity. In addition, Huang et al (40) used DTI technology to analyze changes in whole brain microstructure in patients with strabismus. They found that the FA value of bilateral precuneus was significantly increased, suggesting enhanced fiber bundle integrity in this brain area.…”

Section: Discussionmentioning

confidence: 99%

Altered brain activity in patients with strabismus and amblyopia detected by analysis of regional homogeneity: A�resting‑state functional magnetic resonance imaging study

Shao

et al. 2019

Mol Med Report

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Previous studies have demonstrated that strabismus or amblyopia can result in marked brain function and anatomical alterations. However, differences in spontaneous brain activity in strabismus and amblyopia (SA) patients as compared with control individuals remain unclear. The present study aimed to analyze the potential brain activity changes in SA patients and their association with behavioral performance. In total, 16 patients with SA (10 women and 6 men) and 16 healthy controls (HCs; 6 men and 10 women) with matched age and sex were recruited. All subjects were examined with resting-state functional magnetic resonance imaging (rs-fMRI), and changes in the spontaneous brain activity of SA patients were evaluated by the regional homogeneity (ReHo) method. The diagnostic ability of the ReHo method was assessed using receiver operating characteristic (ROC) curve analysis. In addition, the association between the mean ReHo value in different brain regions and the behavioral performance was explored by correlation analysis. It was observed that the ReHo value was significantly increased in SA patients compared with HCs in the following brain regions: left lingual gyrus, right middle occipital gyrus/precuneus, bilateral anterior cingulate, left middle occipital gyrus and bilateral precentral gyrus. By contrast, the ReHo value of the left inferior frontal gyrus was significantly lower than that in HCs. ROC curve analysis indicated that the ReHo method has certain credibility for the diagnosis of SA patients. In addition, no similar changes were detected in other brain regions. These results revealed abnormal spontaneous brain activity in certain parts of the brain in adult patients with SA, which suggests the involvement of the neuropathological or compensatory mechanism in these patients, and may be beneficial for clinical treatment.

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Section: Discussionmentioning

confidence: 99%

Altered brain activity in patients with strabismus and amblyopia detected by analysis of regional homogeneity: A�resting‑state functional magnetic resonance imaging study

Shao

et al. 2019

Mol Med Report

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“… 60 Hayakawa et al 58 suggested that the cerebellar posterior vermis was related to saccadic eye movements. Huang et al 61 found the mean diffusivity values in the bilateral cerebellum posterior lobe were significantly decreased in comitant strabismus patients, and Tan et al 54 found DC values of comitant exotropia strabismus patients reduced in the right cerebellum posterior lobe. Moreover, lower ALFF value of strabismus subjects has been observed in the bilateral cerebellum posterior lobe.…”

Section: Discussionmentioning

confidence: 99%

Altered spontaneous brain activity patterns in strabismus with amblyopia patients using amplitude of low-frequency fluctuation: a resting-state fMRI study

Min¹,

Su²,

Shu³

et al. 2018

NDT

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ObjectivePrevious studies have demonstrated that strabismus or amblyopia can result in markedly brain function and anatomical alterations. However, the differences in spontaneous brain activities of strabismus with amblyopia (SA) patients still remain unclear. This current study intended to use the amplitude of low-frequency fluctuation (ALFF) technique to investigate the intrinsic brain activity changes in SA subjects.Patients and methodsA total of 16 patients with SA (6 males and 10 females) and 16 healthy controls (HCs; 6 males and 10 females) similarly matched in age, gender, and education status were recruited and examined with the resting-state functional MRI. The spontaneous brain activity changes were investigated using the ALFF technique. The receiver operating characteristic curve was performed to classify the mean ALFF signal values of the SA patients from HCs. The correlations between the ALFF values of distinct brain regions and the clinical manifestations in SA patients were evaluated in terms of the Pearson’s correlation analysis.ResultsCompared with HCs, SA patients had significantly decreased ALFF in the left cerebellum posterior lobe, left middle frontal gyrus, and bilateral thalamus. In contrast, SA patients showed increased ALFF values in the right superior frontal gyrus, right precuneus, left cuneus, and bilateral precentral gyrus. Nonetheless, there was no linear correlation between the mean ALFF values in brain regions and clinical features.ConclusionDiverse brain regions including vision-related and motion-related areas exhibited aberrant intrinsic brain activity patterns, which imply the neuropathologic mechanisms of oculomotor disorder and vision deficit in the SA patients.

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“… 16 Similarly, in previous voxel-wise studies, FA values were increased in the medial frontal gyrus of patients with comitant exotropia. 11 The voxel-wise degree centrality in the temporal gyrus was increased in a study of the functional brain activity network. 17 Given that the ILF is not only the major association pathway that links the occipital cortex with the temporal lobe (an indirect pathway is also linked to the frontal lobe), 18 we speculate that this phenomenon might indicate more numerous dense connections or less branching within fiber bundles, representing the underlying neuropathologic mechanism.…”

Section: Discussionmentioning

confidence: 99%

“… 21 Likewise, previous investigators have also found that FA values were decreased in the IFO. 11 The IFO connects the frontal and occipital lobes along with the lateral border of the caudate nucleus. The IFO is thought to be vital for integrating information among these remote brain regions.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of alterations in white matter integrity of adult patients with comitant exotropia

Zeng

2018

J Int Med Res

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ObjectiveThis study was performed to investigate structural abnormalities of the white matter in patients with comitant exotropia using the tract-based spatial statistics (TBSS) method.MethodsDiffusion tensor imaging data from magnetic resonance images of the brain were collected from 20 patients with comitant exotropia and 20 age- and sex-matched healthy controls. The FMRIB Software Library was used to compute the diffusion measures, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD). These measures were obtained using voxel-wise statistics with threshold-free cluster enhancement.ResultsThe FA values in the right inferior fronto-occipital fasciculus (IFO) and right inferior longitudinal fasciculus were significantly higher and the RD values in the bilateral IFO, forceps minor, left anterior corona radiata, and left anterior thalamic radiation were significantly lower in the comitant exotropia group than in the healthy controls. No significant differences in the MD or AD values were found between the two groups.ConclusionsAlterations in FA and RD values may indicate the underlying neuropathologic mechanism of comitant exotropia. The TBSS method can be a useful tool to investigate neuronal tract participation in patients with this disease.

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Microstructural changes of whole brain in patients with comitant strabismus: evidence from a diffusion tensor imaging study

Cited by 24 publications

References 33 publications

Altered brain activity in patients with strabismus and amblyopia detected by analysis of regional homogeneity: A�resting‑state functional magnetic resonance imaging study

Altered brain activity in patients with strabismus and amblyopia detected by analysis of regional homogeneity: A�resting‑state functional magnetic resonance imaging study

Altered spontaneous brain activity patterns in strabismus with amblyopia patients using amplitude of low-frequency fluctuation: a resting-state fMRI study

Analysis of alterations in white matter integrity of adult patients with comitant exotropia

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