Microstructural changes after half-dose photodynamic therapy in patients with chronic central serous chorioretinopathy

Esen, Ebru; Demircan, Nihal

doi:10.1016/j.pdpdt.2021.102347

Cited by 2 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the studies on retinal morphology alterations in the course of CSCR have concentrated on compromised ONL and POS layers [11][12][13][14][15][16][17][18][19][20][24][25][26][27][28]. ONL and POS thinning is consequently reported in chronic cases of CSCR and usually correlated with BCVA deficit [11][12][13][14][15][16][17][18]20]. Interestingly, Ooto et al [19] reported ONL thinning but not POS thinning in 36 eyes with CSC versus healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…Spectral domain optical coherence tomography (SD-OCT) testing has made it possible to evaluate individual retinal layers in the course of different retinal disorders, including CSCR [9,10]. Because this chorioretinopathy typically presents with subretinal fluid (SRF) and detachment of photoreceptors from the retinal pigment epithelium (RPE), most of the available CSCR studies concentrate on changes to the photoreceptor outer segments layer (POS) and outer nuclear layer (ONL) comprised of photoreceptor nuclei [11][12][13][14][15][16][17][18][19][20]. Literature evaluating the impact of CSCR on more inner retinal layers, including the ganglion cell complex layer (GC), is scarce [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ganglion Cell Loss in the Course of Central Serous Chorioretinopathy

Gawęcki¹,

Grzybowski

2022

Ophthalmol Ther

View full text Add to dashboard Cite

Introduction: Central serous chorioretinopathy (CSCR) as a clinical entity is potentially damaging and may significantly affect retinal morphology and function, especially in the chronic form. Our study aimed to determine the amount of deficit of best corrected visual acuity (BCVA) and individual retinal layers, including ganglion cells, in different types of CSCR and with reference to its duration. Methods: The retrospective analysis included 69 eyes of patients with resolved CSCR managed in Dobry Wzrok Ophthalmological Clinic between 1 January 2019 and 30 June 2022. The diagnosis of CSCR was based on the criteria outlined by the Central Serous Chorioretinopathy International Group. The analysis included data obtained from medical history, BCVA testing, and spectral domain optical coherence tomography (SD-OCT) measurements, with specific thickness values for individual retinal layers. The results were compared among affected eyes, unaffected fellow eyes, and healthy controls.Results: BCVA values were significantly lower in acute (0.08 ± 0.12 logMAR) and chronic (0.26 ± 0.19 logMAR) cases versus controls (0.0 logMAR). The thickness of all retinal layers (central subfoveal thickness, CST; inner retina with ganglion cell complex, GC; outer retina, ORT; and photoreceptor outer segments, POS) and macular volume (MV) were significantly decreased in chronic eyes versus controls (p \ 0.01). Acute eyes had significant thinning of the outer retina and POS only compared to control eyes (p \ 0.01). The amount of deficit in CST, ORT, GC, and MV was strongly correlated with poorer BCVA (p \ 0.001), and the deficit of CST, ORT, and GC was correlated with disease duration (p \ 0.05). The subfoveal choroidal thickness was significantly greater in affected and fellow eyes versus controls (p \ 0.001). Conclusion: Damage to the outer retina and photoreceptors occurs early in the course of CSCR, with a deficit in ganglion cells noted adjunctively in chronic forms of the disease. Further studies are required to precisely determine correlation between visual loss in CSCR and deficits in individual retinal layers.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ganglion Cell Loss in the Course of Central Serous Chorioretinopathy

Gawęcki¹,

Grzybowski

2022

Ophthalmol Ther

View full text Add to dashboard Cite

show abstract

“…Similar improvements are noted by Fukuyama et al 93 . A major morphological PDT effect is the reduction of CT 94 , 95 , 96 . Interestingly, despite overall thickness reduction, the choroidal vascular index is not affected by the procedure.…”

Section: Resultsmentioning

confidence: 99%

Laser Treatment of Central Serous Chorioretinopathy – An Update

Gawecki,

Pytrus,

Swiech

et al. 2024

Klin Monbl Augenheilkd

View full text Add to dashboard Cite

Laser treatment has been a mainstay for management of central serous chorioretinopathy for a few decades. Different types of lasers have been used and non-damaging retinal laser is the most recent option. The aim of this review is to provide an update on this form of treatment, based on the research published during last 5 years, in comparison with earlier studies published. A MEDLINE database search was performed with a combination of the following terms: central serous chorioretinopathy and laser photocoagulation or subthreshold laser or subthreshold micropulse laser or nanosecond laser or microsecond laser or end-point management or photodynamic therapy. Results were analyzed separately for each modality of laser treatment. Reports published in recent years confirm findings of previous research and do not distinguish treatments of this clinical entity. Among all analyzed laser options, photodynamic therapy provides the fastest and most prominent morphological improvements, including subretinal fluid resorption and reduction of choroidal thickness. This modality is also associated with fewer recurrences than with other treatments. Subthreshold micropulse laser allows the physician to maintain and, in selected cases, improve the patientʼs vision. Conventional photocoagulation is still effective, especially with the introduction of navigated laser systems. Despite the availability of variable laser treatment options, long-term functional improvements in chronic cases are minor for each modality. Long-lasting central serous chorioretinopathy cases with significantly altered retinal morphology do not usually present with functional improvement, despite satisfactory morphological outcomes. Early initiation of treatment has the potential to prevent visual loss and to improve the patientʼs quality of life.

show abstract

Microstructural changes after half-dose photodynamic therapy in patients with chronic central serous chorioretinopathy

Cited by 2 publications

References 36 publications

Ganglion Cell Loss in the Course of Central Serous Chorioretinopathy

Ganglion Cell Loss in the Course of Central Serous Chorioretinopathy

Laser Treatment of Central Serous Chorioretinopathy – An Update

Contact Info

Product

Resources

About