Microstructural but not macrostructural cortical degeneration occurs in Parkinson’s disease with mild cognitive impairment

Bai, Xueqin; Guo, Tao; Chen, Jingwen; Guan, Xiaojun; Zhou, Cheng; Wu, Jingjing; Liu, Xiaocao; Wu, Haoting; Wen, Jiaqi; Gu, Luyan; Gao, Ting; Xuan, Min; Huang, Peiyu; Zhang, Baorong; Xu, Xiaojun; Zhang, Minming

doi:10.1038/s41531-022-00416-6

Cited by 10 publications

(10 citation statements)

References 56 publications

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“…As aforementioned, DTI is not a common method for evaluating the GM (particularly in the cortex) because detecting the anisotropy of GM anatomy is challenging, which limits the widespread use of standard diffusion anisotropy metrics ( 58 , 59 ). Meanwhile, cortical microstructural alterations were reported to precede morphological changes ( 60 ). Taken together, this finding lends further support to the suggestion that NODDI indices are potentially more sensitive as biomarkers for detecting cortical microstructural changes in ASD.…”

Section: Discussionmentioning

confidence: 99%

Reduced neurite density index in the prefrontal cortex of adults with autism assessed using neurite orientation dispersion and density imaging

Arai,

Kamagata,

Uchida

et al. 2023

Front. Neurol.

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BackgroundCore symptoms of autism-spectrum disorder (ASD) have been associated with prefrontal cortex abnormalities. However, the mechanisms behind the observation remain incomplete, partially due to the challenges of modeling complex gray matter (GM) structures. This study aimed to identify GM microstructural alterations in adults with ASD using neurite orientation dispersion and density imaging (NODDI) and voxel-wise GM-based spatial statistics (GBSS) to reduce the partial volume effects from the white matter and cerebrospinal fluid.Materials and methodsA total of 48 right-handed participants were included, of which 22 had ASD (17 men; mean age, 34.42 ± 8.27 years) and 26 were typically developing (TD) individuals (14 men; mean age, 32.57 ± 9.62 years). The metrics of NODDI (neurite density index [NDI], orientation dispersion index [ODI], and isotropic volume fraction [ISOVF]) were compared between groups using GBSS. Diffusion tensor imaging (DTI) metrics and surface-based cortical thickness were also compared. The associations between magnetic resonance imaging-based measures and ASD-related scores, including ASD-spectrum quotient, empathizing quotient, and systemizing quotient were also assessed in the region of interest (ROI) analysis.ResultsAfter controlling for age, sex, and intracranial volume, GBSS demonstrated significantly lower NDI in the ASD group than in the TD group in the left prefrontal cortex (caudal middle frontal, lateral orbitofrontal, pars orbitalis, pars triangularis, rostral middle frontal, and superior frontal region). In the ROI analysis of individuals with ASD, a significantly positive correlation was observed between the NDI in the left rostral middle frontal, superior frontal, and left frontal pole and empathizing quotient score. No significant between-group differences were observed in all DTI metrics, other NODDI (i.e., ODI and ISOVF) metrics, and cortical thickness.ConclusionGBSS analysis was used to demonstrate the ability of NODDI metrics to detect GM microstructural alterations in adults with ASD, while no changes were detected using DTI and cortical thickness evaluation. Specifically, we observed a reduced neurite density index in the left prefrontal cortices associated with reduced empathic abilities.

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Section: Discussionmentioning

confidence: 99%

Reduced neurite density index in the prefrontal cortex of adults with autism assessed using neurite orientation dispersion and density imaging

Arai,

Kamagata,

Uchida

et al. 2023

Front. Neurol.

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“…NODDI allows for the compartmentalization of the diffusion imaging signal in intra- (i.e., axons and dendrites) and extra- (i.e., glia, cerebrospinal fluid) neuritic spaces, leading to estimates of the microstructural complexity of different tissues in the brain [ 131 ]. Notably, NODDI measures have been shown to be more sensitive than standard diffusion tensor imaging measures (e.g., fractional anisotropy) to structural-developmental changes in normative [ 25 , 132 , 133 ] and clinical [ 87 , 88 , 89 , 134 , 135 , 136 , 137 ] samples. Specific NODDI metrics include the free-water isotropic volume fraction (FISO), reflecting the free water volume fraction; the Neurite Density Index (NDI), reflecting the intra-neurite density; and the Orientation Dispersion Index (ODI), reflecting the angular dispersion of neurites.…”

Section: Role Of Neuroimaging In Concussionmentioning

confidence: 99%

Emotional Regulation and Adolescent Concussion: Overview and Role of Neuroimaging

Santos

Jia-Richards

Kontos

et al. 2023

IJERPH

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Emotional dysregulation symptoms following a concussion are associated with an increased risk for emotional dysregulation disorders (e.g., depression and anxiety), especially in adolescents. However, predicting the emergence or worsening of emotional dysregulation symptoms after concussion and the extent to which this predates the onset of subsequent psychiatric morbidity after injury remains challenging. Although advanced neuroimaging techniques, such as functional magnetic resonance imaging and diffusion magnetic resonance imaging, have been used to detect and monitor concussion-related brain abnormalities in research settings, their clinical utility remains limited. In this narrative review, we have performed a comprehensive search of the available literature regarding emotional regulation, adolescent concussion, and advanced neuroimaging techniques in electronic databases (PubMed, Scopus, and Google Scholar). We highlight clinical evidence showing the heightened susceptibility of adolescents to experiencing emotional dysregulation symptoms following a concussion. Furthermore, we describe and provide empirical support for widely used magnetic resonance imaging modalities (i.e., functional and diffusion imaging), which are utilized to detect abnormalities in circuits responsible for emotional regulation. Additionally, we assess how these abnormalities relate to the emotional dysregulation symptoms often reported by adolescents post-injury. Yet, it remains to be determined if a progression of concussion-related abnormalities exists, especially in brain regions that undergo significant developmental changes during adolescence. We conclude that neuroimaging techniques hold potential as clinically useful tools for predicting and, ultimately, monitoring the treatment response to emotional dysregulation in adolescents following a concussion.

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“…Likewise, Guo et al 34 have shown that PD patients have decreased ODI in the bilateral nigrostriatal-nigropallidal pathway as well as in the left limbic pathway in comparison to HC. Focusing on the cognitive symptoms in PD patients, Bai et al 35 have demonstrated that reduction in ODI values in the right frontal and bilateral caudate nuclei areas in PD patients with mild cognitive impairment compared to PD patients with normal cognition. Bange et al 36 have reported a positive correlation between the gait rhythm and ISO values in the right SN area.…”

Section: Introductionmentioning

confidence: 99%

Gait impairment-related axonal degeneration in Parkinson’s disease by neurite orientation dispersion and density imaging

Wei,

Wang,

Zhang

et al. 2024

npj Parkinsons Dis.

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Microstructural alterations in the brain networks of Parkinson’s disease (PD) patients are correlated with gait impairments. Evaluate microstructural alterations in the white matter (WM) fiber bundle tracts using neurite orientation dispersion and density imaging (NODDI) technique in PD versus healthy controls (HC). In this study, 24 PD patients and 29 HC were recruited. NODDI and high-resolution 3D structural images were acquired for each participant. The NODDI indicators, including the intracellular neurite density index (NDI), orientation dispersion index (ODI), and isotropic volume fraction (ISO), were compared between the two groups. Diffusion-weighted (DW) images were preprocessed using MRtrix 3.0 software and the orientation distribution function to trace the main nerve fiber tracts in PD patients. Quantitative gait and clinical assessment scales were used to compare the medication “ON” and “OFF” states of PD patients. The NDI, ODI, and ISO values of the WM fiber bundles were significantly higher in PD patients compared to HC. Fiber bundles, including the anterior thalamic radiation, corticospinal tract, superior longitudinal fasciculus, forceps major, cingulum, and inferior longitudinal fasciculus, were found to be significantly affected in PD. The NDI changes of PD patients were well correlated with stride lengths in the “ON” state; ODI changes were correlated with the stride time in the “ON” and “OFF” states and ISO changes were correlated with the stride time and cadence in the “ON” state. In conclusion, combination of NODDI technique and gait parameters can help detect gait impairment in PD patients early and accurately.

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Microstructural but not macrostructural cortical degeneration occurs in Parkinson’s disease with mild cognitive impairment

Cited by 10 publications

References 56 publications

Reduced neurite density index in the prefrontal cortex of adults with autism assessed using neurite orientation dispersion and density imaging

Reduced neurite density index in the prefrontal cortex of adults with autism assessed using neurite orientation dispersion and density imaging

Emotional Regulation and Adolescent Concussion: Overview and Role of Neuroimaging

Gait impairment-related axonal degeneration in Parkinson’s disease by neurite orientation dispersion and density imaging

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