Microstructural analysis and bioactive response of selectively engineered glass-ceramics in simulated body fluid

Vyas, Abhijit; Kumawat, Vijay Shankar; Ghosh, Subrata Bandhu; Bandyopadhyay‐Ghosh, Sanchita

doi:10.1080/10667857.2020.1774208

Cited by 10 publications

(20 citation statements)

References 24 publications

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“…From the IR spectrum of μ‐FC glass ceramic, the peak splitting at 568 and 600 cm −1 can be observed, indicating the formation of crystalline apatite. [ 26 ] The IR peak at around 460 cm −1 is attributed to the SiOSi bending, present in both glass ceramic samples and glass ceramic loaded biocomposite bone scaffold samples. [ 26 ] The PO bending at 604 cm −1 is attributed to the phosphate based apatite phase.…”

Section: Resultsmentioning

confidence: 99%

“…[ 26 ] The IR peak at around 460 cm −1 is attributed to the SiOSi bending, present in both glass ceramic samples and glass ceramic loaded biocomposite bone scaffold samples. [ 26 ] The PO bending at 604 cm −1 is attributed to the phosphate based apatite phase. [ 27 ] Further, the presence of carbonate based CO 3 2− stretching vibration at 1366 cm −1 represents the carbonate based apatite in the μ‐FC glass ceramic structure.…”

Section: Resultsmentioning

confidence: 99%

“…The hydrophilicity can be attributed to the bioactive apatite phases present in the FC glass ceramic structure as corroborated by the XRD results. [ 26 ] Figure 5B shows the behavior of the neat SG resin (cured) sample. For biocomposite bone scaffold samples with 10 and 20 wt% loading of FC glass ceramic as shown in figure 5C,D, respectively, increase in hydrophilicity can be observed due to increase in loading.…”

Section: Resultsmentioning

confidence: 99%

“…This is further followed by crushing the glass frits and subjecting them to heat treatment process for conversion into glass ceramic. [26] The glass ceramics were ball milled for several hours in a high energy ball mill (Retsch, E max ) to convert them into microparticulates . [27] 3.2 | Fabrication of biocomposite scaffolds…”

Section: Synthesis Of Fluorcanasite Glass Ceramic Particulatesmentioning

confidence: 99%

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Digital light processing mediated 3D printing of biocomposite bone scaffolds: Physico‐chemical interactions and in‐vitro biocompatibility

et al. 2022

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This study reports development of digital light processing (DLP) mediated 3D printed customized bone scaffolds. Bioactive fluorcanasite glass ceramic was incorporated within photocurable resin matrix and the suspensions were 3D printed towards developing composite bone scaffolds. Physico-chemical interaction in the biocomposite bone scaffolds were investigated using infrared spectroscopy, x-ray diffraction, and field emission scanning electron microscopy. Further, the mechanical properties of the composite scaffold samples were also evaluated to understand the strengths of the samples in terms of its fracture toughness, flexural strength, and compressive strength. Infrared spectroscopy results demonstrated an active interaction between the acrylate functionalities of the polymer with the bioactive fluorcanasite glass ceramic reinforcement. This was further substantiated with x-ray diffraction results, demonstrating rise in the bioactive crystalline peaks with corresponding increase in the fluorcanasite glass ceramic loading. Later, the samples were also evaluated for in-vitro cellular response in terms of cell viability, proliferation, adhesion, and interaction. The surface hydrophilicity responsible for osteogenic interaction was also studied with contact angle goniometry. With increase in fluorcanasite loading in the formulation, the hydrophilicity was found to increase over the sample surface which in turn was found to enhance cell adhesion and proliferation, as revealed byin-vitro MTT assay and also fluorescence microscopy. To establish the efficacy of DLP technique, two different porous architectural designs were 3D printed and investigated with synchrotron micro-computed tomography. The microtomographs revealed precise microarchitecture and interconnected porosity within the scaffolds.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Synthesis Of Fluorcanasite Glass Ceramic Particulatesmentioning

confidence: 99%

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Digital light processing mediated 3D printing of biocomposite bone scaffolds: Physico‐chemical interactions and in‐vitro biocompatibility

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“…8,21 The key constraint of these metallic biomaterials is associated with significant difference in mechanical properties as compared to natural bone, resulting in stress shielding. 22,23 Additionally, these metallic biomaterials lack biodegradable properties, leading to mandatory secondary surgery for removing the implants, that may cause post-operative problems. 24,25 In this regard, magnesium (Mg), a biodegradable metallic biomaterial can offer a suitable alternative for load-bearing applications, considering that its mechanical properties such as Young's modulus and compressive strength are similar to natural human bone.…”

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confidence: 99%

Bioactive fluorcanasite reinforced magnesium alloy‐based porous bio‐nanocomposite scaffolds with tunable mechanical properties

et al. 2022

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Magnesium (Mg) alloy-based porous bio-nanocomposite bone scaffolds were developed by powder metallurgy route. Selective alloying elements such as calcium (Ca), zinc (Zn) and strontium (Sr) were incorporated to tune the mechanical integrity while, bioactive fluorcanasite nano-particulates were introduced within the alloy system to enhance the bone tissue regeneration. Green compacts containing carbamide were fabricated and sintered using two-stage heat treatment process to achieve the targeted porosities. The microstructure of these fabricated magnesium alloy-based bio-nanocomposites was examined by Field emission scanning electron microscope (FE-SEM) and x-ray micro computed tomography (x-ray μCT), which revealed gradient porosities and distribution of alloying elements. X-ray diffraction (XRD) studies confirmed the presence of major crystalline phases in the fabricated samples and the evolution of the various combinations of intermetallic phases of Ca, Mg, Zn and Sr which were anticipated to enhance the mechanical properties. Further, XRD studies revealed the presence of apatite phase for the immersed samples, a conducive environment for bone regeneration. The fabricated samples were evaluated for their mechanical performance against uniaxial compression load. The tunability of compressive strengths and modulus values could be established with variation in porosities of fabricated samples. The retained compressive strength and Young's modulus of the samples following immersion in phosphate buffered saline (PBS) solution was found to be in line with that of natural human cancellous bone, thereby establishing the potential of the fabricated magnesium-alloy-based nanocomposite as a promising scaffold candidate for bone tissue engineering.

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Recent advances on injectable nanocomposite hydrogels towards bone tissue rehabilitation

Phogat

Ghosh

Bandyopadhyay‐Ghosh

2022

J of Applied Polymer Sci

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There has been significant interest in the recent past to develop injectable hydrogel scaffolds that follow minimally invasive implantation procedures towards efficient healing and regeneration of defective bone tissues. Such scaffolds offer several advantages, as they can be injected into the irregularly shaped defect and can act as a low‐density aqueous reservoir, incorporating necessary components for bone tissue repair and augmentation. Considering that bone is a biocomposite of natural biopolymer and bioapatite nanofiller, there has been a growing trend to develop nanocomposite scaffolds by combining biopolymers and inorganic nanofillers to biomimic the hierarchical nanostructure and composition of natural bone. Furthermore, the nanocomposite scaffolds can be tailored to have patient‐specific bone properties, which can lead to better biological responses. The present article begins with the introduction, followed by an overview of polymer matrices, property requirements, and crosslinking techniques employed for injectable hydrogels. Various strategies to develop injectable composites, with emphasis on nanocomposite hydrogels incorporating bioinert and bioactive nanofillers have been discussed. The fundamental challenges related to the development of injectable hydrogel nanocomposite scaffolds and the research efforts directed towards solving these problems have also been reviewed. Finally, future trends and conclusions on new generation injectable hydrogel nanocomposite bone scaffolds have been discussed in this article.

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Microstructural analysis and bioactive response of selectively engineered glass-ceramics in simulated body fluid

Cited by 10 publications

References 24 publications

Digital light processing mediated 3D printing of biocomposite bone scaffolds: Physico‐chemical interactions and in‐vitro biocompatibility

Digital light processing mediated 3D printing of biocomposite bone scaffolds: Physico‐chemical interactions and in‐vitro biocompatibility

Bioactive fluorcanasite reinforced magnesium alloy‐based porous bio‐nanocomposite scaffolds with tunable mechanical properties

Recent advances on injectable nanocomposite hydrogels towards bone tissue rehabilitation

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