Microstereolithography-fabricated microneedles for fluid sampling of histamine-contaminated tuna

Boehm, Ryan D.; Jaipan, Panupong; Yang, Kai‐Hung; Stewart, Thomas N.; Narayan, Roger J.

doi:10.18063/ijb.2016.01.010

Cited by 7 publications

(5 citation statements)

References 30 publications

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“…Distinguishable by clarity, the following is a non-exhaustive list of medical grade resins: dimethacrylate (DMA) [ 109 ], polymethylmethacrylate (PMMA), [ 110 ] and Methyl methacrylate/acrylonitrile/butadiene styrene (MABS) [ 111 ]. Specifically, linked to SLA are methacrylate-based proprietary photoresins [ 56 , 57 , 112 ] and acrylic-based photoresins [ 43 , 54 , 55 ]. While methacrylate-based monomers used in bone cements [ 113 ], dental fillings are considered to be biocompatible [ 114 ], their long-term implantation has been associated with irritancy and cytotoxicity.…”

Section: Discussionmentioning

confidence: 99%

“…Although 3D printing for MNs was first investigated in 2007 by Ovsianikov et al [ 42 ] while using a lithography-based multiphoton polymerization printing method, the ability to print biocompatible and biodegradable materials from conventional 3D printing methods, such as stereolithography (SLA), FDM™, Selective Laser Sintering (SLS), CLIP, and Digital Light Processing (DLP) [ 43 , 44 , 45 ] has been the focus of numerous studies presented in Table S3 . The biofabrication methods have been classified under the AM processes outlined in ISO/ASTM 52900:2015 [ 46 ].…”

Section: Introductionmentioning

confidence: 99%

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Three-Dimensional (3D) Printed Microneedles for Microencapsulated Cell Extrusion

et al. 2018

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Cell-hydrogel based therapies offer great promise for wound healing. The specific aim of this study was to assess the viability of human hepatocellular carcinoma (HepG2) cells immobilized in atomized alginate capsules (3.5% (w/v) alginate, d = 225 µm ± 24.5 µm) post-extrusion through a three-dimensional (3D) printed methacrylate-based custom hollow microneedle assembly (circular array of 13 conical frusta) fabricated using stereolithography. With a jetting reliability of 80%, the solvent-sterilized device with a root mean square roughness of 158 nm at the extrusion nozzle tip (d = 325 μm) was operated at a flowrate of 12 mL/min. There was no significant difference between the viability of the sheared and control samples for extrusion times of 2 h (p = 0.14, α = 0.05) and 24 h (p = 0.5, α = 0.05) post-atomization. Factoring the increase in extrusion yield from 21.2% to 56.4% attributed to hydrogel bioerosion quantifiable by a loss in resilience from 5470 (J/m3) to 3250 (J/m3), there was no significant difference in percentage relative payload (p = 0.2628, α = 0.05) when extrusion occurred 24 h (12.2 ± 4.9%) when compared to 2 h (9.9 ± 2.8%) post-atomization. Results from this paper highlight the feasibility of encapsulated cell extrusion, specifically protection from shear, through a hollow microneedle assembly reported for the first time in literature.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Three-Dimensional (3D) Printed Microneedles for Microencapsulated Cell Extrusion

et al. 2018

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“…In order to manufacture hollow microneedle (HMN) arrays, 3D printing technology is often utilized because of its cost efficiency, high throughput, and affinity for customization [19,20]. Conventional 3D printing methods for HMN fabrication include stereolithography (SLA), also known as vat photopolymerization (VPP), the Fused Deposition Method (FDM TM ), Selective Laser Sintering (SLS), Continuous Liquid Interface Production (CLIP), and Digital Light Processing (DLP) [21][22][23][24][25]. SLA is a 3D printing process where a UV laser cures liquid monomer molecules in the photoresin, via free radical polymerization, into a cross-linked polymer.…”

Section: Introductionmentioning

confidence: 99%

An Integrated Approach to Control the Penetration Depth of 3D-Printed Hollow Microneedles

Defelippi,

Kwong,

Appleget

et al. 2024

Applied Mechanics

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A variety of hollow microneedle (HMN) designs has emerged for minimally invasive therapies and monitoring systems. In this study, a design change limiting the indentation depth of the (3D) printed custom microneedle assembly (circular array of five conical frusta with and without a stopper, aspect ratio = 1.875) fabricated using stereolithography has been experimentally validated and modeled in silico. The micro-indentation profiles generated in confined compression on 1 mm ± 0.073 mm alginate films enabled the generation of a Prony series, where displacement ranged from 100 to 250 µm. These constants were used as intrinsic properties simulating experimental ramp/release profiles. Puncture occurred on two distinct hydrogel formulations at the design depth of 150 µm and indentation rate of 0.1 mm/s characterized by a peak force of 3.5 N (H = 31 kPa) and 8.3 N (H = 36.5 kPa), respectively. Experimental and theoretical alignments for peak force trends were obtained when the printing resolution was simulated. Higher puncture force and uniformity inferred by the stopper was confirmed via microscopy and profilometry. Meanwhile, poroviscoelasticity characterization is required to distinguish mass loss vs. redistribution post-indentation through pycnometry. Results from this paper highlight the feasibility of insertion-depth control within the epidermis thickness for the first time in solid HMN literature.

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“…However, it should also be noted that this photocuring-based 3D printing technology has limitation in utilizing various functional materials such as ceramics and metals. In recent years, DLP has been rapidly developed and is widely used in the prototype production of various products, dental technology, jewelry manufacturing, and implementation of metamaterials, owing to its high precision and fast printing speed [21][22][23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

3D printing of metasurface-based dual-linear polarization converter

Lee¹,

Noh²,

Lee³

et al. 2021

Flex. Print. Electron.

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3D printing using digital light processing (DLP) technology has been studied in various fields because of its ability to create complex shapes through a simple process. In this study, DLP 3D printing was employed in the implementation of the metasurface-based dual-linear polarization converter (DLPC). The unit cell of the metasurface-based DLPC for linear polarization conversion was designed consisting of the upper and lower dipole-pair antennas connected through vias and a shielding layer that electrically shields the antennas from each other, and its fabrication was based on the characterization results of the dielectric properties of the photocurable substrate materials and electrical properties of the conductive materials used for synthesizing the metasurface. The printability evaluation of dipole pairs, vias, and a shielding layer was carried out to implement the detailed structures of the DLPC in 3D printing. The electromagnetic wave transmission characteristics of the 3D-printed 8×8 array DLPC demonstrated an orthogonal polarization conversion, as predicted by the simulation results. This study confirmed that the DLP-based 3D printing technology can go beyond the existing functions of manufacturing objects and can be applied to the implementation of various electronics based on different meta-structures.

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Microstereolithography-fabricated microneedles for fluid sampling of histamine-contaminated tuna

Cited by 7 publications

References 30 publications

Three-Dimensional (3D) Printed Microneedles for Microencapsulated Cell Extrusion

Three-Dimensional (3D) Printed Microneedles for Microencapsulated Cell Extrusion

An Integrated Approach to Control the Penetration Depth of 3D-Printed Hollow Microneedles

3D printing of metasurface-based dual-linear polarization converter

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