Microspheres prepared with a temperature‐responsive macromonomer

Abstract

A macromonomer was prepared from succinimido methacrylate and poly(N-isopropylacrylamide) (PIPA) with an amino end group. The macromonomer (MA-PIPA) obtained shows a temperature-responsive transition phenomenon from coil to globule in water at about 36 "C. For the copolymer of MA-PIPA with acrylamide (ratio of monomer residues of Nisopropylacrylamide (IPA) and acrylamide (AAm) 10 : 3), the transition temperature of the PIPA chain was the same as that of the macromonomer, whereas the transition temperature of a linear copolymer of IPA and AAm (ratio of the monomer residues 10: 3) was much higher than that of PIPA (52 "C). Microspheres were prepared by emulsion polymerization of the macromonomer and styrene in the presence of sodium dodecylsulfate. The microspheres obtained show a temperature responsiveness in the critical flocculation concentration. The macromonomer prepared here can be used as a component of temperature-sensitive devices in various forms.

Scalable and Concise Synthesis of Dichlorofluorescein Derivatives Displaying Tissue Permeation in Live Zebrafish Embryos

“…Park and Hoffman proposed poly(NIPA) gel as a thermoreversible support for the immobilization of β ‐galactosidase 8. Succinimide‐functionalized thermosensitive polymers were examined as carriers in the immobilization of different enzymes as they possess direct reaction ability with the amino groups 9–11. Lipase was covalently immobilized onto a graft copolymer prepared by coupling of poly[(acrylic acid)‐ co ‐acrylamide] with amine‐terminated poly(NIPA) 12.…”

RNA-sensitive N-isopropylacrylamide/vinylphenylboronic acid random copolymer

“…[8] Succinimide-functionalized thermosensitive polymers were examined as carriers in the immobilization of different enzymes as they possess direct reaction ability with the amino groups. [9][10][11] Lipase was covalently immobilized onto a graft copolymer prepared by coupling of poly[(acrylic acid)-co-acrylamide] with amine-terminated poly(NIPA). [12] Plain and functional NIPA-based gels were tried as carriers in the immobilization of a-chymotrypsin.…”

Graft copolymers having hydrophobic backbone and hydrophilic branches. XVIII. Poly(styrene) nanospheres with novel thermosensitive poly(N-vinylisobutyramide)s on their surfaces

“…For the last 12 years, researchers have developed synthesis of polymeric nanospheres on which hydrophilic polymers are grafted by using the free radical polymerization of hydrophilic macromonomers and hydrophobic comonomers in a polar solvent. [1][2][3][4] Any hydrophilic polymer can be introduced on the surface of a nanosphere by using this method. Regulating the monomers used and the reaction conditions can also easily control their surface properties such as the density or the molecular weight of their hydrophilic polymers, the charge or its distribution, and the stimuli responsibility.…”