Microspectrofluorometric Analysis of Surface Antigens of Murine Melanoma and Hamster Peritoneal Cell Hybrids: Comparisons of Species Antigenicity, Chromosome Number, and Tumorigenicity
Abstract:Somatic cell hybrids from viral fusions of murine melanoma (PAZG) × Chinese hamster peritoneal cells (CH) were compared with respect to surface antigenicity, karyotype and tumorigenicity. One line, F57-(9), which arose from the hybridization of two CH cells and one PAZG cell, had slight (6%) CH chromosome loss but 80% PAZG chromosome loss after 10 months in culture. These cells expressed CH antigens strongly and PAZG antigens weakly. In comparison, another hybrid, F57-(7), formed from one CH and one PAZG cell,… Show more
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