Microsomal metabolism of ciprofloxacin generates free radicals

Gürbay, Aylin; Gonthier, B.; Daveloose, Denis; Favier, A.; Hıncal, Filiz

doi:10.1016/s0891-5849(01)00508-1

Cited by 63 publications

(43 citation statements)

References 11 publications

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“…5 The repeated administration of ofloxacin, a fluoroquinolone antibiotic, resulted in increased LPO, which may be due to the generation of free radicals. 17 The decreased activities of antioxidant enzymes viz catalase and SOD suggested that the process of dismutation of the free radicals by SOD was being interrupted, which further impeded the rate of H 2 O 2 production and later its decomposition by catalase. Glutathione status, which is accepted as a good indicator of the oxidative stress, 18 declined significantly in blood and liver of all the treated animals, which in turn may cause accumulation of toxic peroxides and superoxides resulting in tissue damage.…”

Section: Discussionmentioning

confidence: 99%

Ofloxacin-associated retinopathy in rabbits: role of oxidative stress

et al. 2008

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Ofloxacin, a quinolone, is an extensively used, well-tolerated antibacterial agent but has been reported to induce photosensitivity at low incidences. In the present investigation, the possible role of oxidative stress in ofloxacin-induced retinopathy in rabbits was evaluated. It was observed that ofloxacin at a dose rate of 10 and 20 mg/rabbit, twice daily for 21 consecutive days, resulted in significant elevation in the extent of lipid peroxidation and depletion of the blood glutathione levels. Marked alterations were also observed in various parameters of the glutathione-redox cycle. There was significant increase in the enzymic activity of glutathione peroxidase and glutathione reductase, whereas a significant decrease was observed in the activities of superoxide dismutase, catalase, and glutathione-S-transferase enzymes. Histopathological studies revealed retinal damage especially in the pigmented cell layer. Degenerative changes in liver and kidneys were also observed. Liver showed focal areas of necrosis, dilation of sinusoids, and cellular infiltration, whereas in kidneys, there was glomerular and tubular degeneration, suggesting impaired renal functioning.

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Section: Discussionmentioning

confidence: 99%

Ofloxacin-associated retinopathy in rabbits: role of oxidative stress

et al. 2008

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“…The use of antibiotics was justified by their antimicrobial activity and for some of these (penicillins, quinolones, rifamycins, and macrolides) by their anti-inflammatory action and stimulatory effect on the immune system ( [22][23][24][25][26][27][28][29][30]; M. Albrizio et al, unpublished data, 2014). Moreover, the antibiotics, such as penicillins and quinolones, can also affect the oxidative state of the organism and the production of reactive oxygen species [30][31][32][33][34]. Several studies have reported that antibiotic therapy is able to directly modulate the contractility of smooth muscles [35][36][37][38][39] also.…”

Section: Introductionmentioning

confidence: 99%

Modulatory effect of three antibiotics on uterus bovine contractility in vitro and likely therapeutic approaches in reproduction

et al. 2014

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“…21 As a result of fluoroquinolone metabolism, free radical intermediates are generated that can subsequently cause lipid peroxidation. 22 In this sense the administration of enrofloxacin in drinking water could influence the antioxidant enzyme activities to a greater extent than the cathepsin activities. Some studies have been done on the effect of the administration of enrofloxacin in poultry diets on raw meat quality.…”

Section: Introductionmentioning

confidence: 99%

Influence of enrofloxacin administration on the proteolytic and antioxidant enzyme activities of raw and cooked turkey products

Carreras¹,

Castellari²,

Valero³

et al. 2005

J Sci Food Agric

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The objective of this study was to assess the effect of enrofloxacin administration with and without withdrawal period on the quality of fresh meat and cooked products from turkey breasts. Cathepsin B and L activities were inactivated by the thermal process but were not affected by the presence of enrofloxacin. The level of enrofloxacin in samples without withdrawal time was higher than the regulatory maximum residue limit (MRL). The antioxidant enzymes glutathione peroxidase (GSHPx) and catalase (CAT) were affected by both the thermal process and the antibiotic residues in cooked meat. In no cases were differences found in superoxide dismutase (SOD) activity, supporting the theory that this enzyme could play a major role in preventing lipid oxidation of cooked meat. Enrofloxacin residues could contribute to an increase in the oxidative stress produced by thermal processing, as can be deduced by the reduction in GSHPx and CAT activities.

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Microsomal metabolism of ciprofloxacin generates free radicals

Cited by 63 publications

References 11 publications

Ofloxacin-associated retinopathy in rabbits: role of oxidative stress

Ofloxacin-associated retinopathy in rabbits: role of oxidative stress

Modulatory effect of three antibiotics on uterus bovine contractility in vitro and likely therapeutic approaches in reproduction

Influence of enrofloxacin administration on the proteolytic and antioxidant enzyme activities of raw and cooked turkey products

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