Microsomal Desaturation of Linoleic into γ-LinoIenic Acid in Livers of Fetal, Suckling and Pregnant Rats

Satomi, S; Matsuda, Isao

doi:10.1159/000240535

Cited by 26 publications

(14 citation statements)

References 6 publications

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“…This is evident for all three membrane fractions in vestigated. The same phenomenon has been observed by Satomi and Matsuda [23] in microsomes of fetal rat liver.…”

Section: Resultssupporting

confidence: 87%

Fatty Acid Composition of some Cellular Membranes of Fetal Rat Liver

Luit¹,

Berger²,

Hommes³

1975

Neonatology

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The fatty acid composition of lipids of inner mitochondrial membrane, rough and smooth endoplasmic reticulum of adult and fetal rat liver has been determined. Subcellular membranes of fetal liver show a higher content of palmitic acid and oleic acid and a lower content of stearic acid and arachidonic acid as compared to subcellular membranes of the adult liver. The activity of citrate lyase and acetyl-CoA carboxylase of rat liver cytosol has been determined as a function of age. It is concluded that the differences are due to a relativedeficiency of the fatty acid elongation system. The higher degree of saturation of the fatty acids of the phospholipids of the fetal membranes may be the cause of altered permeability properties of these membranes, as illustrated by the slower rate of isoosmotic swelling in the presence of the ammonium salt of some of the Krebs cycle intermediates in fetal rat liver mitochondria.

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“…This is evident for all three membrane fractions in vestigated. The same phenomenon has been observed by Satomi and Matsuda [23] in microsomes of fetal rat liver.…”

Section: Resultssupporting

confidence: 87%

Fatty Acid Composition of some Cellular Membranes of Fetal Rat Liver

Luit¹,

Berger²,

Hommes³

1975

Neonatology

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“…Following the peak of intestinal absorption by the mother, the peaks of specific activity stand at about 3 h for linoleic and arachidonic acids in both the maternal and the fetal plasma, at the same time as the peaks of the ratio of the specific activities arachidonic acid/linoleic acid. As this ratio remains unchanged in the placenta, about 0.04, this organ obviously does not synthesize actively arachidonic acid; this is in accordance with Satomi and Matsuda (9). The quotient of the fetal ratio and the maternal ratio is always very different from 1, being 3 at 1 h, 13 at 3 h and 0.4 at 6 h after labelling.…”

Section: I4c Retention and Distributionsupporting

confidence: 85%

“…This could result from heterogenous pools of arachidonic acid in the livers. Although Strouve-Vallet and Pascaud (10) concluded from in vitro experiments to a very low desaturation of linoleic to -y-linolenic acid by the fetal liver microsomes, Satomi and Matsuda (9) report an in vivo synthesizing activity before birth in both maternal and fetal livers. One cannot exclude an extrahepatic tissue which could synthesize arachidonic acid during pregnancy.…”

Section: Origin O F the Fetal '*C-linoleic And Arachidonic Acidsmentioning

confidence: 99%

Assimilation of <sup>14</sup>C-Linoleic Acid by the Rat Fetus

Pascaud

Rougier

Delhaye³

1977

Ann Nutr Metab

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Following ingestion, by the 20-day pregnant mother, of (1-¹⁴C)linoleic acid, the retention and distribution of ‘⁴C are determined in the fetus, placenta and mother, after 1, 3 and 6 h. Comparison of the specific activities of linoleic and arachidonic acids in the maternal plasma, liver and placenta, and the fetal plasma, liver and carcass leads to the conclusion of a selective materno-fetal transfer of arachidonic acid, relative to linoleic acid, through the placenta.

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“…Comparison of our data concerning the liver of the -1 day fetus, 1.3 nmol of y-linolenic acid synthesized per milligram micro somal proteins in 1 h. with the data of Satomi and Matsuda [7], 0.56 nmol in 20 min, is dif ficult due to the very different in vitro exper- imental conditions. However, a similar de crease of the enzymatic activity is observed in the -1 day to + 1 day perinatal period.…”

mentioning

confidence: 43%