1973
DOI: 10.1159/000240535
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Microsomal Desaturation of Linoleic into γ-LinoIenic Acid in Livers of Fetal, Suckling and Pregnant Rats

Abstract: In order to estimate the synthesis of arachidonate in the liver of fetal, suckling and pregnant rats, the conversion rate of linoleate to γ-linolenate was studied. The significantly higher conversion rate was found both in fetal and pregnant animal, whereas the ratio of arachidonate to linoleate in plasma lipid as well as in liver microsomal lipid was not elevated in pregnant rats. Instead of reduced conversion rate of 6-day suckling rats, the ratio of arachidonate to linoleate in plasma was higher than that o… Show more

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Cited by 26 publications
(14 citation statements)
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“…This is evident for all three membrane fractions in vestigated. The same phenomenon has been observed by Satomi and Matsuda [23] in microsomes of fetal rat liver.…”
Section: Resultssupporting
confidence: 87%
“…This is evident for all three membrane fractions in vestigated. The same phenomenon has been observed by Satomi and Matsuda [23] in microsomes of fetal rat liver.…”
Section: Resultssupporting
confidence: 87%
“…Following the peak of intestinal absorption by the mother, the peaks of specific activity stand at about 3 h for linoleic and arachidonic acids in both the maternal and the fetal plasma, at the same time as the peaks of the ratio of the specific activities arachidonic acid/linoleic acid. As this ratio remains unchanged in the placenta, about 0.04, this organ obviously does not synthesize actively arachidonic acid; this is in accordance with Satomi and Matsuda (9). The quotient of the fetal ratio and the maternal ratio is always very different from 1, being 3 at 1 h, 13 at 3 h and 0.4 at 6 h after labelling.…”
Section: I4c Retention and Distributionsupporting
confidence: 85%
“…This could result from heterogenous pools of arachidonic acid in the livers. Although Strouve-Vallet and Pascaud (10) concluded from in vitro experiments to a very low desaturation of linoleic to -y-linolenic acid by the fetal liver microsomes, Satomi and Matsuda (9) report an in vivo synthesizing activity before birth in both maternal and fetal livers. One cannot exclude an extrahepatic tissue which could synthesize arachidonic acid during pregnancy.…”
Section: Origin O F the Fetal '*C-linoleic And Arachidonic Acidsmentioning
confidence: 99%
“…Comparison of our data concerning the liver of the -1 day fetus, 1.3 nmol of y-linolenic acid synthesized per milligram micro somal proteins in 1 h. with the data of Satomi and Matsuda [7], 0.56 nmol in 20 min, is dif ficult due to the very different in vitro exper- imental conditions. However, a similar de crease of the enzymatic activity is observed in the -1 day to + 1 day perinatal period.…”
mentioning
confidence: 43%