Microsomal and peroxisomal fatty acid oxidation in bile duct ligated rats: A comparative study between liver and kidney

Orellana, Myriam; Avalos, Nicolás; Abarca, Montserrat; Valdés, Elena

doi:10.1016/s0306-3623(96)00278-9

Cited by 9 publications

(4 citation statements)

References 30 publications

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“…High levels of glucose are a major symptom of diabetes and the detection of glucose in the urine is relevant in selecting the treatment against this pathology, once there is a direct correlation between glucose concentration in the urine and in the blood [35]. The administration of A. humile extract in diabetic rats significantly reduced the levels of glucose excretion in the urine compared with results obtained for untreated rats (Figure 2(b)).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Hypoglycemic Properties ofAnacardium humileAqueous Extract

Urzêda

Marcussi

Pereira

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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The antihyperglycemic effects of several plant extracts and herbal formulations which are used as antidiabetic formulations have been described and confirmed to date. The main objective of this work was to evaluate the hypoglycemic activity of the aqueous extract of Anacardium humile. Although the treatment of diabetic animals with A. humile did not alter body weight significantly, a reduction of the other evaluated parameters was observed. Animals treated with A. humile did not show variation of insulin levels, possibly triggered by a mechanism of blood glucose reduction. Levels of ALT (alanine aminotransferase) decreased in treated animals, suggesting a protective effect on liver. Levels of cholesterol were also reduced, indicating the efficacy of the extract in reestablishing the balance of nutrients. Moreover, a kidney protection may have been achieved due to the partial reestablishment of blood glucose homeostasis, while no nephrotoxicity could be detected for A. humile. The obtained results demonstrate the effectiveness of A. humile extracts in the treatment of alloxan-induced diabetic rats. Therefore, A. humile aqueous extract, popularly known and used by diabetic patients, induced an improvement in the biochemical parameters evaluated during and following treatment of diabetic rats. Thus, a better characterization of the medicinal potential of this plant will be able to provide a better understanding of its mechanisms of action in these pathological processes.

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Section: Resultsmentioning

confidence: 99%

Evaluation of the Hypoglycemic Properties ofAnacardium humileAqueous Extract

Urzêda

Marcussi

Pereira

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…It is accepted that there is a strong correlation between experimental obstructive jaundice and oxidative stress [ 64 , 65 , 68 ]. However, BDL mainly impairs the liver ability of antioxidant regeneration, especially at the mitochondrial level [ 66 ].…”

Section: The Ischemia/reperfusion Phenotypementioning

confidence: 99%

Experimental obstructive cholestasis: the wound-like inflammatory liver response

Aller

Arias

García-Domínguez

et al. 2008

Fibrogenesis Tissue Repair

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Obstructive cholestasis causes hepatic cirrhosis and portal hypertension. The pathophysiological mechanisms involved in the development of liver disease are multiple and linked. We propose grouping these mechanisms according to the three phenotypes mainly expressed in the interstitial space in order to integrate them.Experimental extrahepatic cholestasis is the model most frequently used to study obstructive cholestasis. The early liver interstitial alterations described in these experimental models would produce an ischemia/reperfusion phenotype with oxidative and nitrosative stress. Then, the hyperexpression of a leukocytic phenotype, in which Kupffer cells and neutrophils participate, would induce enzymatic stress. And finally, an angiogenic phenotype, responsible for peribiliary plexus development with sinusoidal arterialization, occurs. In addition, an intense cholangiocyte proliferation, which acquires neuroendocrine abilities, stands out. This histopathological finding is also associated with fibrosis.It is proposed that the sequence of these inflammatory phenotypes, perhaps with a trophic meaning, ultimately produces a benign tumoral biliary process -although it poses severe hepatocytic insufficiency. Moreover, the persistence of this benign tumor disease would induce a higher degree of dedifferentiation and autonomy and, therefore, its malign degeneration.

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“…Retention and accumulation of hydrophobic bile acids may induce hepatocyte necrosis by inducing mitochondrial membrane permeability transition and a decrease in glutathione (GSH) and antioxidant activities of hepatic catalase (CAT) [6][7][8][9][10], and in this way can contribute to oxidative stress.…”

Section: Introductionmentioning

confidence: 99%