Microsensors for Microreaction and Lab-on-a-Chip Applications

Knapkiewicz, Paweł; Walczak, Rafał

doi:10.5772/16388

Cited by 7 publications

(6 citation statements)

References 7 publications

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“…Often, microreactors are used for highly exothermic reactions or for the handling of hazardous and toxic substances due to their advantageous small holdups and resulting high specific surfaces [31]. Here, standard temperature sensors and their measurement techniques must be adapted to the respective microreactor or microfluidic chip, while readyto-use solutions do not exist [32]. Several requirements must be fulfilled by microscale temperature sensors.…”

Section: Integrated Temperature Sensorsmentioning

confidence: 99%

Smart Equipment – A Perspective Paper

Kockmann

Bittorf

Krieger

et al. 2018

Chemie Ingenieur Technik

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Chemical equipment has to form a robust and efficient process space and was developed over the last centuries to very sophisticated, often highly specialized devices. With the upcoming information technology new opportunities arise with integrated sensors, and advanced control systems. Smart equipment is designed in form of intelligent modules. Furthermore, adaptive and integrated actuators convert the control signals to directly influence the process, thus, they can be described as responsive equipment. This contribution will give an overview of some activities in this field.

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Section: Integrated Temperature Sensorsmentioning

confidence: 99%

Smart Equipment – A Perspective Paper

Kockmann

Bittorf

Krieger

et al. 2018

Chemie Ingenieur Technik

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“…Based on the technical results presented here, the miniature chemical plant for the nitration of fluorotoluene has been worked out [11,22]. The plant consists of a Foturan R glass microreactor equipped with five temperature sensors and five newly designed pressure sensors, tailored electronics and software.…”

Section: Applicationsmentioning

confidence: 99%

“…The characterization of the microreactor itself in terms of its performance characteristics (e.g., pressure drops, flow, temperature), as well as the characterization of 'chemistry' being carried out in the microreactor, must be done by the use of a set of a new kind of microsensor. Dead volume of microsensors, the resistance against aggressive chemicals and the leak proofness of fluidic connections formed between microsensors and the microreactor chip are three of the most important factors here [11].…”

Section: Introductionmentioning

confidence: 99%

The silicon–glass microreactor with embedded sensors—technology and results of preliminary qualitative tests, toward intelligent microreaction plant

Knapkiewicz¹

2013

J. Micromech. Microeng.

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The technology and preliminary qualitative tests of silicon–glass microreactors with embedded pressure and temperature sensors are presented. The concept of microreactors for leading highly exothermic reactions, e.g. nitration of hydrocarbons, and design process-included computer-aided simulations are described in detail. The silicon–glass microreactor chip consisting of two micromixers (multistream micromixer), reaction channels, cooling/heating chambers has been proposed. The microreactor chip was equipped with a set of pressure and temperature sensors and packaged. Tests of mixing quality, pressure drops in channels, heat exchange efficiency and dynamic behavior of pressure and temperature sensors were documented. Finally, two applications were described.

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“…However, hydrodynamic studies comprising flow regimes, pressure drop and RTD within µPBR are relatively rare, and tools for the characterisaton are typically sought among those used for the large scale packed-bed reactors [11]. Therefore the application of compatible, equi-scaled analytical devices is highly desirable to push this technology towards the "synergy of miniaturization" [12]. In this respect, biosensors are taking special place as powerful analytical tools that utilize a biological recognition component enabling rapid and selective on-line detection and quantification analytes.…”

Section: Introductionmentioning

confidence: 99%

Characterization of an enzymatic packed-bed microreactor: Experiments and modeling

Strniša

Bajić

Panjan

et al. 2018

Chemical Engineering Journal

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A micro packed-bed reactor (µPBR) based on two-parallel-plates configuration with immobilized Candida antarctica lipase B in the form of porous particles (Novozym ® 435) was theoretically and experimentally characterized. A residence time distribution (RTD) within µPBRs comprising various random distributions of particles placed in one layer was computationally predicted by a mesoscopic lattice Boltzmann (LB) method. Numerical simulations were compared with measurements of RTD, obtained by stimulus-response experiment with a pulse input using glucose as a tracer, monitored by an electrochemical glucose oxidase microbiosensor integrated with the reactor. The model was validated by a good agreement between the experimental data and predictions of LB model at different conditions.

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Microsensors for Microreaction and Lab-on-a-Chip Applications

Cited by 7 publications

References 7 publications

Smart Equipment – A Perspective Paper

Smart Equipment – A Perspective Paper

The silicon–glass microreactor with embedded sensors—technology and results of preliminary qualitative tests, toward intelligent microreaction plant

Characterization of an enzymatic packed-bed microreactor: Experiments and modeling

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