Microsecond pulsed glow discharge in copper hollow cathode reveals a new approach to ionization and determination of volatile organic compounds

Gubal, Anna; Chuchina, Victoria; Ivanenko, N. B.; Qiu, Rong; Solovyev, Nikolay; Ганеев, А. А.

doi:10.1016/j.sab.2020.105986

Cited by 4 publications

(15 citation statements)

References 24 publications

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“…The LOD values in the range of 0.5-5 ppb were achieved, which is perspective for the real application of the new approach for a wide range of analytical tasks, including the determination of VOCs in human exhalation. 15,16 When comparing our results with previous studies, 1,3,5 the following aspects may be identified. The combination of several factors related to the nature of the pulsed glow discharge resulted in the combination of two beneficial outcomes for the online detection mode, which are often hard to achieve together.…”

Section: No + + M → No + M +supporting

confidence: 50%

“…1 Besides, we used a relatively low discharge power of 3 W, additionally reducing the degree of fragmentation. In our previous study, 5 we used copper-associates CuM + for the detection of VOCs and observed a low degree of fragmentation under the discharge parameters favouring their formation; however, it resulted in more than one order of magnitude reduced sensitivity compared to the use of molecular ions as in the current study.…”

Section: No + + M → No + M +mentioning

confidence: 60%

“…The increase of air pressure reduced the sensitivities of the VOCs and increased the intensity of the copper associates, as observed in our previous study. 5 The optimised pressure provided signal maximisation of the analytes and led to minimisation of the background intensities. VOC ionisation was undertaken via short discharge pulses (2.0-3.5 µs).…”

Section: Resultsmentioning

confidence: 99%

“…1,2 Several studies addressed the application of glow discharge mass spectrometry (GDMS) in molecular analysis. [1][2][3][4][5] Fandino et al investigated two variants of GDMS application: as a detector in gas chromatography and under a continuous flow of VOCs (benzene, toluene, ethylbenzene, and xylene) in an artificial air mixture. 3 The afterglow of the discharge was used for the ionisation, employing mainly the Penning process.…”

Section: Introductionmentioning

confidence: 99%

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New Possibilities for the Determination of Volatile Organic Compounds by Their Molecular Ions in Air Using µs-Pulsed GD TOFMS

Gubal¹

2021

At.Spectrosc.

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A recent trend in glow discharge analysis, previously considered as a 'purely inorganic' technique, is related to the effective ionisation of volatile organic compounds (VOCs). This approach was demonstrated to be capable of analysing VOCs in both model gas mixtures and ambient air. In the current study, the possibility of the direct determination of VOCs of different classes of organic compounds (including toluene, p-xylene, chlorobenzene and 1,2,4-trimethylbenzene) in ambient air using microsecond pulsed glow discharge time-of-flight mass spectrometry (µs-Pulsed GD TOFMS) with copper hollow cathode was demonstrated. The ionisation processes with the formation of molecular ions M + , which can be used for quantification, were discussed. The fragmentation of detected molecular ions of VOCs was found to be quite low, which benefits both qualitative and quantitative determination. The ease of identification and relative simplicity of the mass spectrum is promising for the analysis of VOC mixtures. One of the possible applications of the designed method is the direct determination of VOCs in human exhaled breath for the diagnosis of lung diseases, including lung cancer. However, revealing its potential applicability for this purpose requires further research.

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Section: No + + M → No + M +supporting

confidence: 50%

Section: No + + M → No + M +mentioning

confidence: 60%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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New Possibilities for the Determination of Volatile Organic Compounds by Their Molecular Ions in Air Using µs-Pulsed GD TOFMS

Gubal¹

2021

At.Spectrosc.

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“…In our previous study [ 24 ], we used pulsed glow discharge in a copper hollow cathode coupled to a TOFMS for the quantification of VOCs as CuM + associates. Under the discharge cell conditions used [ 24 ], a high concentration of copper atoms was maintained in the GD, which facilitated the formation of CuM species with their consequent ionization by two mechanisms. The first mechanism was the Penning process; the second one was related to the high-energy electron packet, forming on the front of the discharge pulse [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Volatile Organic Compound Fragmentation in the Afterglow of Pulsed Glow Discharge in Ambient Air

et al. 2022

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Glow discharge (GD) source gained an increased level of attention in relation to the analysis of volatile organic compounds (VOCs) since past work showed that this soft ionization method allowed direct analysis of VOCs with minimal fragmentation, however, the issue of fragmentation was not previously studied in detail. The aim of the present work was to investigate the effect of discharge conditions on VOC fragmentation in the system consisting of the cell with pulsed glow discharge and a time-of-flight mass spectrometer. Ionization of VOCs of different classes (hydrocarbons, alcohols, esters, and carboxylic acids) was investigated. A copper cathode with flat geometry was used. VOCs were ionized in the afterglow of short pulse glow discharge in the air. The use of discharge afterglow significantly reduces or eliminates the effects of ionization mechanisms other than Penning process, in particular, electron ionization. This significantly reduced VOC fragmentation and provided rather low limits of detection. Specific cluster formation was observed for alcohols and esters, which may facilitate their identification.

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Atomic spectrometry update: review of advances in the analysis of metals, chemicals and materials

Carter

Clough

Fisher

et al. 2021

J. Anal. At. Spectrom.

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Microsecond pulsed glow discharge in copper hollow cathode reveals a new approach to ionization and determination of volatile organic compounds

Cited by 4 publications

References 24 publications

New Possibilities for the Determination of Volatile Organic Compounds by Their Molecular Ions in Air Using µs-Pulsed GD TOFMS

New Possibilities for the Determination of Volatile Organic Compounds by Their Molecular Ions in Air Using µs-Pulsed GD TOFMS

Volatile Organic Compound Fragmentation in the Afterglow of Pulsed Glow Discharge in Ambient Air

Atomic spectrometry update: review of advances in the analysis of metals, chemicals and materials

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