Microscopic Proven Endometriosis in Pericolic Adhesions Showing Peritoneal Typical and Atypical Lesions

Pereira, Ricardo; Petri, Claus; Paula, F.; Filho, V. Maia; Motta, E.L.A.; Serafini, P.

doi:10.1016/j.fertnstert.2005.07.503

Cited by 1 publication

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“…Starting from the abdominal lateral parietocolic gutters, it has been observed a high prevalence of bilateral colonto-sidewall adhesions in women with chronic pelvic pain and associated pelvic endometriosis [39]. Besides, as much as 60% of these adhesions may harbor histological proven endometriotic lesions [40]. In the Fallopian tubes, endometriosis foci maybe found adjacent to embryonic duct remnants, and the histological evaluation of those lesions suggests the existence of a gradual transformation from embryonic remnants epithelium to endometrial glands [41].…”

Section: Hoxa10 May Influence the Formation Of Misplaced Endometrial mentioning

confidence: 99%

The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review

Zanatta

Rocha

Carvalho³

et al. 2010

J Assist Reprod Genet

169

118

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Purpose Endometriosis and its associated infertility have been the object of continuous research for over a century. To understand the molecular mechanisms underlying the disease, it has become necessary to determine the aspects of its etiology that are not explained by the retrograde menstruation theory. This could in turn elucidate how various clinical and surgical treatments might affect the evolution and remission of the disease.Methods This review is focused on the most recent clinical and laboratory findings regarding the association of HOXA10 with endometriosis and infertility. Result The homebox (Hox/HOX) proteins are highly conserved transcription factors that determine segmental body identities in multiple species, including humans. Hoxa10/ HOXA10 is directly involved in the embryogenesis of the uterus and embryo implantation via regulation of downstream genes. Cyclical endometrial expression of Hoxa10/HOXA10, with a peak of expression occurring during the window of implantation, is observed in the adult in response to estrogen and progesterone. Women with endometriosis do not demonstrate the expected mid-luteal rise of HOXA10 expression, which might partially explain the infertility observed in many of these patients. Recent studies also demonstrated HOXA10 expression in endometriotic foci outside the Müllerian tract. Conclusions Multiple lines of evidence suggest that the actions of the homeobox A10 (Hoxa10/HOXA10) gene could account for some aspects of endometriosis.

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Section: Hoxa10 May Influence the Formation Of Misplaced Endometrial mentioning

confidence: 99%

The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review

Zanatta

Rocha

Carvalho³

et al. 2010

J Assist Reprod Genet

169

118

View full text Add to dashboard Cite

show abstract

Microscopic Proven Endometriosis in Pericolic Adhesions Showing Peritoneal Typical and Atypical Lesions

Cited by 1 publication

References 0 publications

The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review

The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review

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