Microscopic Mechanism of Specific Peptide Adhesion to Semiconductor Substrates

Abstract

We are thankful to Simon Mitternacht for helpful discussions regarding the peptide model and C. Dammann for peptide synthesis and purification. MB thanks the DFG (German Science * To whom correspondence should be addressed Foundation) and the Wenner-Gren Foundation (Sweden) for research fellowships, and the German-Israel "Umbrella" program for support. MB, AI, and WJ are grateful for support by the German-Swedish DAAD-STINT Personnel Exchange Programme. This work is also partially funded by the DFG under Grant Nos. JA 483/24-1/2/3, the Leipzig Graduate School of Excellence "BuildMoNa", TR 67 A4, and the German-French DFH-UFA PhD College under Grant No. CDFA-02-07. Supercomputer time at the John von Neumann Institute for Computing (NIC), Forschungszentrum Jülich, is acknowledged (Grant Nos. hlz11 and jiff39).

Affinity and Selectivity of Peptides for Inorganic Materials: A Thermodynamic Discussion of the Role of Conformational Flexibility

“…In fact, simulations have suggested that amino acids can adhere to different extents on different crystal planes, 9,10,[42][43][44] not dissimilarly from what happens for adhesion to different materials. Within the simple model presented here, selectivity between two different crystal planes may well be due to E int rather than the more obvious geometrical mismatch.…”

Protein folding/unfolding in the presence of interacting macromolecular crowders

“…The model has subsequently been applied to study folding/unfolding properties of several proteins with >90 residues [75][76][77][78][79][80][81]. Other applications include peptide aggregation [82][83][84] and peptide adhesion to solid surfaces [85].…”

Adsorption of polymers at nanowires

“…Many of the special properties of these structures, that make them potential candidates for technological applications, can be controlled, influenced or amplified by coating them with polymeric material [3,4]. In previous computational works, for example, the wetting of cylindrical fibers with polymers or the helical wrapping of single polymers around nanocylinders were studied [9,10].…”