Microscopic magnetic resonance elastography of traumatic brain injury model

Boulet, Thomas; Kelso, Matthew L.; Othman, Shadi F.

doi:10.1016/j.jneumeth.2011.08.019

Cited by 52 publications

(37 citation statements)

References 37 publications

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“…Where possible, direct measures of brain material properties in vivo are complementing past studies. For example, recent results using brain MR elastography provides estimates of the changes that occur in vivo and are in the range of properties derived from previous in vivo and in situ measurements [11,[71][72][73][74][75].…”

Section: An Integrated Multiscale Approach For Understanding Traumatmentioning

confidence: 99%

The Mechanics of Traumatic Brain Injury: A Review of What We Know and What We Need to Know for Reducing Its Societal Burden

Meaney

Morrison

Bass

2014

Journal of Biomechanical Engineering

200

126

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Traumatic brain injury (TBI) is a significant public health problem, on pace to become the third leading cause of death worldwide by 2020. Moreover, emerging evidence linking repeated mild traumatic brain injury to long-term neurodegenerative disorders points out that TBI can be both an acute disorder and a chronic disease. We are at an important transition point in our understanding of TBI, as past work has generated significant advances in better protecting us against some forms of moderate and severe TBI. However, we still lack a clear understanding of how to study milder forms of injury, such as concussion, or new forms of TBI that can occur from primary blast loading. In this review, we highlight the major advances made in understanding the biomechanical basis of TBI. We point out opportunities to generate significant new advances in our understanding of TBI biomechanics, especially as it appears across the molecular, cellular, and whole organ scale.

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Section: An Integrated Multiscale Approach For Understanding Traumatmentioning

confidence: 99%

The Mechanics of Traumatic Brain Injury: A Review of What We Know and What We Need to Know for Reducing Its Societal Burden

Meaney

Morrison

Bass

2014

Journal of Biomechanical Engineering

200

126

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“…15 This algorithm can be executed in < 1 min using a conventional desktop to calculate the mechanical properties.…”

Section: Inversion Algorithmmentioning

confidence: 99%

“…The stiffness of the somatosensory cortex of the impacted hemisphere decreased by 25% following TBI. 15 Such strong results prompted an in vivo study.…”

Section: Introductionmentioning

confidence: 99%

Long-Term In Vivo Imaging of Viscoelastic Properties of the Mouse Brain after Controlled Cortical Impact

Boulet

Kelso

Othman

2013

Journal of Neurotrauma

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Traumatic brain injury (TBI) presents a variety of causes and symptoms, thus making the development of reliable diagnostic methods and therapeutic treatments challenging. Magnetic resonance elastography (MRE) is a technique that allows for a noninvasive assessment of the mechanical properties of soft biological tissue, such as tissue stiffness, storage modulus, and loss modulus. Importantly, by quantifying the changes in the stiffness of tissue that is often associated with disease, MRE is able to detect tissue pathologies at early stages. Recent improvements in instrumentation have allowed for the investigation of small samples with microscopic resolution (μMRE). We hypothesize that μMRE can sensitively detect variations in micromechanical properties in the brain caused by the compressive and shearing forces sustained during TBI. To test this hypothesis, we randomized 13 C57BL mice to receive a controlled cortical impact at a 0.5 mm or 0.75 mm depth, with both sham and naïve mice as controls. Our objective was to propagate mechanical shear waves throughout the brain for in vivo TBI μMRE imaging. The mechanical properties of the injured brain tissue were determined at days 0, 1, 7, and 28 post-injury. For both groups, we observed a significant drop in the stiffness of the impacted region immediately following the injury; the 0.75 mm animals experienced increased tissue softness that lasted longer than that for the 0.5 mm group. Although the shear stiffness, storage modulus, and loss modulus parameters all followed the same trend, the tissue stiffness yielded the most statistically significant results. Overall, this article introduces a transformative technique for mechanically mapping the brain and detecting brain diseases and injury.

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“…While there is limited data on tissue elasticity in human TBI patients, ex vivo analysis of rats subjected to controlled cortical impact injury has revealed 23% to 32% lower stiffness in the injured hemisphere, compared with the healthy one. 120 Advanced techniques for evaluation of vascular pathology include both perfusion and permeability imaging. In the clinical setting, perfusion-weighted imaging is often performed by measuring T2* signal change during the first pass of an intravenous bolus of gadolinium contrast (dynamic susceptibility contrast) and generating maps of relative cerebral blood flow/cerebral blood volume (rCBF/CBV) for evaluation of ischemic or neoplastic disease.…”

Section: Other Techniquesmentioning

confidence: 99%

A Review of the Effectiveness of Neuroimaging Modalities for the Detection of Traumatic Brain Injury

Amyot

Arciniegas

et al. 2015

Journal of Neurotrauma

169

147

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The incidence of traumatic brain injury (TBI) in the United States was 3.5 million cases in 2009, according to the Centers for Disease Control and Prevention. It is a contributing factor in 30.5% of injury-related deaths among civilians. Additionally, since 2000, more than 260,000 service members were diagnosed with TBI, with the vast majority classified as mild or concussive (76%). The objective assessment of TBI via imaging is a critical research gap, both in the military and civilian communities. In 2011, the Department of Defense (DoD) prepared a congressional report summarizing the effectiveness of seven neuroimaging modalities (computed tomography [CT], magnetic resonance imaging [MRI], transcranial Doppler [TCD], positron emission tomography, single photon emission computed tomography, electrophysiologic techniques [magnetoencephalography and electroencephalography], and functional near-infrared spectroscopy) to assess the spectrum of TBI from concussion to coma. For this report, neuroimaging experts identified the most relevant peer-reviewed publications and assessed the quality of the literature for each of these imaging technique in the clinical and research settings. Although CT, MRI, and TCD were determined to be the most useful modalities in the clinical setting, no single imaging modality proved sufficient for all patients due to the heterogeneity of TBI. All imaging modalities reviewed demonstrated the potential to emerge as part of future clinical care. This paper describes and updates the results of the DoD report and also expands on the use of angiography in patients with TBI.

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Microscopic magnetic resonance elastography of traumatic brain injury model

Cited by 52 publications

References 37 publications

The Mechanics of Traumatic Brain Injury: A Review of What We Know and What We Need to Know for Reducing Its Societal Burden

The Mechanics of Traumatic Brain Injury: A Review of What We Know and What We Need to Know for Reducing Its Societal Burden

Long-Term In Vivo Imaging of Viscoelastic Properties of the Mouse Brain after Controlled Cortical Impact

A Review of the Effectiveness of Neuroimaging Modalities for the Detection of Traumatic Brain Injury

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