Microscopic intravenous leiomyomatosis: An incidental finding at myomectomy

Wilson, Machelle; Evans, Frankis T.; Mylona, Evangelia K.; Murray, Conor; Govind, Apoorva

doi:10.3109/01443615.2010.513458

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…These include lympho-vascular embolization which is the most accepted theory, seeding from ruptured leiomyoma: metaplasia from mesothelial mesenchyme and true metastases from low-grade leiomyosarcomas of the uterus [15]. While it has been noticed to be associated with diffuse peritoneal leiomyomatosis and intravenous leiomyomatosis [16,17], it is believed that those entities have equivalent pathologic origin [3]. Before making the diagnosis of BML, pathologic and immunohistochemical studies to exclude other neoplasms are essential, especially leiomyosarcoma which can have same features [10].…”

Section: Discussionmentioning

confidence: 99%

Leiomyomas beyond the uterus; benign metastasizing leiomyomatosis with paraaortic metastasizing endometriosis and intravenous leiomyomatosis: a case series and review of the literature

Mahmoud

Desai

Nezhat

2014

Arch Gynecol Obstet

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Uterine leiomyomas affect 20-30 % of women 35 years and older. Extrauterine leiomyomas are rare and present a greater diagnostic challenge. Those unusual growth patterns occur more often in women of reproductive age with a history of hysterectomy or surgery for uterine leiomyomas. They have been reported in the literature in case reports and small case series and include benign metastasizing leiomyoma (BML), disseminated peritoneal leiomyomatosis, intravenous leiomyomatosis (IVL), parasitic leiomyomas, and retroperitoneal growth. In this case series we present a case of BML with a first report of concomitant endometriosis metastasis to paraaortic lymphnodes, and a case of IVL. The findings and surgical management of those cases, as well as a review of the literature pertinent to those entities, are also presented.

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Section: Discussionmentioning

confidence: 99%

Leiomyomas beyond the uterus; benign metastasizing leiomyomatosis with paraaortic metastasizing endometriosis and intravenous leiomyomatosis: a case series and review of the literature

Mahmoud

Desai

Nezhat

2014

Arch Gynecol Obstet

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Update on intravenous leiomyomatosis: report of five patients and literature review

Devesa

Conley

Stone

et al. 2013

European Journal of Obstetrics & Gynecology and Reproductiv

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Clinical features and prognostic factors analysis of intravenous leiomyomatosis

Chen

Zhang

et al. 2023

Front. Surg.

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BackgroundThe treatment and prognostic factors of intravenous leiomyomatosis (IVL) remain lacking systematic evidence.MethodsA retrospective study was conducted on IVL patients from the Qilu Hospital of Shandong University, and IVL cases were published in PubMed, MEDLINE, Embase and Cochrane Library databases. Descriptive statistics were used for the basic characteristics of patients. The Cox proportional hazards regression analysis was used to assess the high-risk factors related to the progression-free survival (PFS). The comparison of survival curves was performed by Kaplan–Meier analysis.ResultsA total of 361 IVL patients were included in this study, 38 patients from Qilu Hospital of Shandong University, and 323 patients from the published literature. Age ≤45 years was observed in 173 (47.9%) patients. According to the clinical staging criteria, stage I/II was observed in 125 (34.6%) patients, and stage III/IV was observed in 221 (61.2%) patients. Dyspnea, orthopnea, and cough were observed in 108 (29.9%) patients. Completed tumor resection was observed in 216 (59.8%) patients, and uncompleted tumor resection was observed in 58 (16.1%) patients. Median follow-up period was 12 months (range 0–194 months), and 68 (18.8%) recurrences or deaths were identified. The adjusted multivariable Cox proportional hazard analysis showed age ≤45 years (vs. >45) (hazard ratio [HR] = 2.09, 95% confidence interval [CI] 1.15–3.80, p = 0.016), and uncompleted tumor resection (vs. completed tumor resection) (HR = 22.03, 95% CI 8.31–58.36, p < 0.001) were high-risk factors related to the PFS.ConclusionPatients with IVL have a high probability of recurrence after surgery and a poor prognosis. Patients younger than 45 years and with uncompleted tumor resection are at higher risk of postoperative recurrence or death.

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Microscopic intravenous leiomyomatosis: An incidental finding at myomectomy

Cited by 3 publications

References 9 publications

Leiomyomas beyond the uterus; benign metastasizing leiomyomatosis with paraaortic metastasizing endometriosis and intravenous leiomyomatosis: a case series and review of the literature

Leiomyomas beyond the uterus; benign metastasizing leiomyomatosis with paraaortic metastasizing endometriosis and intravenous leiomyomatosis: a case series and review of the literature

Update on intravenous leiomyomatosis: report of five patients and literature review

Clinical features and prognostic factors analysis of intravenous leiomyomatosis

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