Microscopic colitis: a common diarrhoeal disease. An epidemiological study in Orebro, Sweden, 1993-1998

Abstract

Background: Microscopic colitis, including collagenous colitis and lymphocytic colitis, mainly affects middle aged and older subjects, with a female predominance in collagenous colitis. The diseases have previously been regarded as rare. We present an epidemiological study of microscopic colitis in a well defined Swedish population. Methods: Patients were retrospectively searched for in colonoscopy reports of those who had a colonoscopy in the period 1993-1998 for non-bloody diarrhoea. All colonic mucosal biopsies were reassessed using strict diagnostic criteria. Results: Biopsies from 1018 patients were reassessed. Fifty one (45 female) collagenous colitis patients and 46 (31 female) lymphocytic colitis patients were diagnosed. Median age at diagnosis was 64 years in collagenous colitis and 59 years in lymphocytic colitis. The mean annual incidence of collagenous colitis was 4.9/10 5 inhabitants (95% confidence interval (CI) 3.6-6.2/10 5 ) and of lymphocytic colitis 4.4/10

Collagenous colitis in children and adolescents: study of 7 cases and literature review

“…Of note, the patient with alternating constipation and 6 This association seems to be more common in children, as 5/14 (36%) children had autoimmune diseases diagnosed prior to or simultaneously with the diagnosis of CC, including celiac disease (2), collagenous sprue and gastritis (2), and juvenile scleroderma (1). Celiac disease was noted in 29% (4/14) pediatric cases (Table 1), higher than that seen in adult population (5/171).…”

“…8 Adult patients with CC have higher rates of autoimmune thyroid disease, celiac disease, and rheumatoid arthritis. 6 CC is exceedingly rare in pediatric patients, 10 and therefore, data on CC of this group is scarce. In this series, we describe the clinical and pathologic features of CC patients under the age of 18 years.…”

“…The mean age at diagnosis is 64 years, but patient age ranges from 29 to 93 years. 6 The female-to-male ratio is 3 to 1. 6 The annual incidence of CC is reported in non-pediatric populations from several European and North America studies to be 0.6-5.2 per 100 000 with a prevalence of 10-39.3 per 100 000.…”

“…6 The female-to-male ratio is 3 to 1. 6 The annual incidence of CC is reported in non-pediatric populations from several European and North America studies to be 0.6-5.2 per 100 000 with a prevalence of 10-39.3 per 100 000. [7][8][9] Patients typically seek medical attention because of chronic, watery, and non-bloody diarrhea.…”

Evolution of ideas on microscopic colitis

“…В настоящее время распространенность МК составляет 103 случая (42 -КК, 69 -ЛК) на 100 000 населения, что сопоставимо с другими воспалительными заболеваниями ки-шечника, такими как язвенный колит (ЯК) и болезнь Крона (БК) [14]. Заболеваемость КК варьируют от 2,6 до 10,8 на 100 000 по-пуляции и ЛК -от 2,2 до 14 на 100 000 [14][15][16].…”