Microscopic and Histochemical Manifestationsof Hyaline Cartilage Dynamics

Malinin, George I.; Malinin, Theodore I.

doi:10.1016/s0079-6336(99)80006-0

Cited by 8 publications

(7 citation statements)

References 257 publications

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“…It also has helped to explain how living organisms can function as integrated mechanical systems, even though they are complex hierarchical structures (molecules within cells within tissues within organs). Indeed, the tensegrity principle has been invoked by investigators to explain an unusually wide range of unexplained phenomena in many different systems and species, including: lipid micelle formation (Butcher and Lamb, 1984), protein folding in milk globules (Farrell et al, 2002), protein organization within viral capsids (Caspar, 1980), the structure of actin microfilaments (Schutt et al, 1997), pattern formation in paramecium (Kaczanowska et al, 1995), hyphal morphology in fungi (Kaminsky and Heath, 1996), neurite outgrowth (Joshi et al, 1985;Buxbaum and Heidemann, 1988), endothelial permeability barrier function (Moy et al, 1998), vascular tone (Northover and Northover, 1993), dystrophin function in muscular dystrophy (Gillis, 1999), choriocarcinoma differentiation (Hohn et al, 1996), control of apoptosis (Ciesla, 2001), morphogenesis of mammalian cells and tissues (Ingber et al, 1981;Ingber and Jamieson, 1985;Pienta and Coffey, 1991a;Pienta et al, 1991;Huang and Ingber, 1999;Ingber et al, 1994), the structure of the skin (Ryan, 1989), lens (Yamada et al, 2000), cartilage (Malinin and Malinin, 1999), retina (Galli-Resta, 2002) and brain (Van Essen, 1997), the mechanics of the human skeleton (Levin, 1997), tumor formation and metastasis (Ingber et al, 1981;Ingber and Jamieson, 1985;Pienta and Coffey, 1991b;Huang and Ingber, 1999), as well as gravity sensing in both animals and plants Yoder e...…”

Section: Resultsmentioning

confidence: 99%

Tensegrity I. Cell structure and hierarchical systems biology

Ingber

2003

Journal of Cell Science

1,119

795

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In 1993, a Commentary in this journal described how a simple mechanical model of cell structure based on tensegrity architecture can help to explain how cell shape, movement and cytoskeletal mechanics are controlled, as well as how cells sense and respond to mechanical forces (J. Cell Sci.104, 613-627). The cellular tensegrity model can now be revisited and placed in context of new advances in our understanding of cell structure,biological networks and mechanoregulation that have been made over the past decade. Recent work provides strong evidence to support the use of tensegrity by cells, and mathematical formulations of the model predict many aspects of cell behavior. In addition, development of the tensegrity theory and its translation into mathematical terms are beginning to allow us to define the relationship between mechanics and biochemistry at the molecular level and to attack the larger problem of biological complexity. Part I of this two-part article covers the evidence for cellular tensegrity at the molecular level and describes how this building system may provide a structural basis for the hierarchical organization of living systems — from molecule to organism. Part II, which focuses on how these structural networks influence information processing networks, appears in the next issue.

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Section: Resultsmentioning

confidence: 99%

Tensegrity I. Cell structure and hierarchical systems biology

Ingber

2003

Journal of Cell Science

1,119

795

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“…Thus, demonstration of viable chondrocytes in a markedly reduced cell population would have little meaning. Cartilage is a complex structure, and its integrity and function depend on its many dynamic interrelationships 40,41 .…”

Section: Discussionmentioning

confidence: 99%

Transplantation of Osteochondral Allografts After Cold Storage

Malinin

Temple

Buck

2006

The Journal of Bone & Joint Surgery

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Time-dependent loss of chondrocytes in articular cartilage stored at hypothermia, especially in specimens stored for longer than fifteen to twenty days, was observed in this study. Cartilage allografts transplanted into nonhuman primates after twenty-one days of storage underwent more severe degenerative changes than allografts that had been stored for less than twenty-one days. These findings suggest caution when transplanting cartilage stored at hypothermia for over twenty days.

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“…The specimens were fixed, decalcified, and embedded in paraffin. The 6‐μm sections were stained with Safranin O/fast green, H&E, and then scored by Mankin grading system [8, 16, 18, 19]. The grading system is based on the assessment of the structure (normal, 0; surface irregularities, 1; pannus and irregularities, 2; clefts to transitional zone, 3; clefts to radial zone, 4; clefts to calcified zone, 5; complete disorganization, 6), cells (normal, 0; hypercellularity, 1; cloning, 2; hypocellularity, 3), histochemistry (normal, 0; slight reduction in staining, 1; moderate reduction, 2; severe reduction, 3; no staining, 4), and tidemark integrity (normal, 0; crossed by vessels or disrupted, 1).…”

Section: Methodsmentioning

confidence: 99%

Nutrition and degeneration of articular cartilage

Wang

Wei

Zeng

et al. 2012

Knee Surg Sports Traumatol Arthrosc

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PurposeTo determine the importance of synovial fluid (SF) or subchondral bone marrow (BM) as nutrition sources in cartilage degeneration.MethodsNinety-five-month-old male rabbits were randomly divided into 5 groups according to sources of nutrition: SFBM-both; BM-only; SF-only; None-SFBM; and Free plug (unrestricted). Nutrition to 4-mm-diameter cylindrical osteochondral plugs created on the trochlea of the distal femurs was obstructed by Polyvinyl Chloride (PVC) cap. Cartilage changes were assessed after 4, 8, and 12 weeks by histology, immunohistochemistry, and real-time PCR.ResultsCartilage in the BM-only group suffered the greatest damage, followed by the None-SFBM and SF-only groups. Apoptosis was increased in the BM-only and None-SFBM groups compared with others. Cartilage was significantly thinner at all time points in the BM-only and None-SFBM groups when compared with SFBM-both and Free plug, whereas in the SF-only group, this difference occurred after 8 weeks. Compared with SFBM-both and Free plug, expression of collagen II and aggrecan mRNAs in all groups was decreased but MMP-3 increased, respectively.ConclusionOur data indicate that SF-derived nutrition is the dominant source of sustenance for adult cartilage structure and function. Cartilage damage is observed when the only nutrition source is the BM.Electronic supplementary materialThe online version of this article (doi:10.1007/s00167-012-1977-7) contains supplementary material, which is available to authorized users.

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Microscopic and Histochemical Manifestationsof Hyaline Cartilage Dynamics

Cited by 8 publications

References 257 publications

Tensegrity I. Cell structure and hierarchical systems biology

Tensegrity I. Cell structure and hierarchical systems biology

Transplantation of Osteochondral Allografts After Cold Storage

Nutrition and degeneration of articular cartilage

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