Microscale chemistry-based design of eco-friendly, reagent-saving and efficient pharmaceutical analysis: A miniaturized Volhard's titration for the assay of sodium chloride

Rojanarata, Theerasak; Sumran, Krissadecha; Nateetaweewat, Paksupang; Winotapun, Weerapath; Sukpisit, Sirarat; Opanasopit, Praneet; Ngawhirunpat, Tanasait

doi:10.1016/j.talanta.2011.06.009

Cited by 8 publications

(3 citation statements)

References 9 publications

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“…In Indonesia, presumably Green Chemistry principles and SSC with their relation to sustainability in chemistry education are still not widely known to university and senior high school students (Hamidah et al, 2017;Listyarini, 2019). Green chemistry and SSC have the same purpose of minimizing the destructive effect of chemistry in the environment and human health (Duarte et al, 2017;Rojanarata et al, 2011). Therefore, Green Chemistry and SSC approach can be used together for pedagogy.…”

Section: Introductionmentioning

confidence: 99%

The Integration of Green Chemistry Principles into Small Scale Chemistry Practicum for Senior High School Students

Listyarini

Pamenang

Harta

et al. 2019

JPII

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Implementation of Principles of Green Chemistry in teaching chemistry can become an essential approach to enhance students' awareness of environmental problem. In contrast with the goal of sustainability, chemistry practicum normally deals with chemicals and waste management which contribute to environmental problem. A shift toward more sustainable and economical experiments is essential to maintain the existence of the practicum in senior high curriculum. Small Scale Chemistry (SSC) practicum is one of the approaches to promote sustainability in chemistry practicum by using smaller scale and safer apparatus. It is expected to produce less waste. It is also safer and more economical chemistry experiment. This research aims to study the integration of principles of green chemistry in chemistry practicum by using SSC experiment. This study investigates two main topics in senior high school chemistry subject: electrochemistry and acid-base indicator. This study has shown the practice of integration of the principles of green chemistry approach into senior high school chemistry practicum through SSC. The experiments demonstrated in this study enable us to integrate Principles of Green Chemistry in terms of preventing waste, using less hazardous chemical, and conducting safer experiments which can be implemented in senior high school chemistry practicum.

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Section: Introductionmentioning

confidence: 99%

The Integration of Green Chemistry Principles into Small Scale Chemistry Practicum for Senior High School Students

Listyarini

Pamenang

Harta

et al. 2019

JPII

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“…5 Screening methodologies based on multi-well plates are employed in qualitative assays with satisfactory results, but they are not so often used for quantitative determinations in the field of Analytical Chemistry. More recently, quantitative applications with multi-well plate readers are becoming popular and successful for well established analytical methods such as chloride determination according to the classical Volhard determination, 6 vitamin C in fruit and tomatoes by derivatization reaction of dehydroascorbate with orthophenylenediamine 7 or lipid analysis by the Van Handel method. 8 The multi-well plate reader format presents a good analytical efficiency together with a notable reduction in time of analysis as well as in the volumes of the reagents and samples.…”

Section: Introductionmentioning

confidence: 99%

A down-scaled fluorimetric determination of the solubility properties of drugs to minimize waste generation

2013

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“…The apparatus is thermally controlled and insulated from the atmosphere with O-rings and grease sealant. Rojanarata et al extended the use of educational micro-titration equipment in pharmaceutical analysis [7] . They selected Volhard's method for the micro-titration of sodium chloride as an example.…”

Section: Introductionmentioning

confidence: 99%

Green Chemistry: A Simple Manual Apparatus for Potentiometric and Conductometric Micro-Titration of Small Samples for the Educational Laboratory

Sweileh¹

2021

JJC

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A simple manual micro-titration method is proposed for the potentiometric and conductometric titration of 200 to 800 µL of liquid samples. The sample to be titrated is dispensed into the titration chamber; the bottom section of a plastic test tube that is glued to the center of a small stirring magnet. After inserting the sensing probe and the tip of the titrant delivery tip into the titration chamber, the chamber-stirring magnet assembly is spun at low speed using a conventional magnetic stirrer. Titrant is delivered (with 0.2 µL resolution) from the submerged tip of a 100-µL capacity micro-pipette by rotating the plunger with the locking ring unlocked. The apparatus has been used for potentiometric titration and conductometric titration of acids and bases usually encountered in educational laboratories. Compared with macro-scale titrations, the obtained accuracy was between +2.2% and -3.9% relative error and the precision ranged between 1.6% and 2.9% relative standard deviation. The proposed procedure cuts the reagent consumption to 1% or less compared with conventional macro-scale titrations.

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Microscale chemistry-based design of eco-friendly, reagent-saving and efficient pharmaceutical analysis: A miniaturized Volhard's titration for the assay of sodium chloride

Cited by 8 publications

References 9 publications

The Integration of Green Chemistry Principles into Small Scale Chemistry Practicum for Senior High School Students

The Integration of Green Chemistry Principles into Small Scale Chemistry Practicum for Senior High School Students

A down-scaled fluorimetric determination of the solubility properties of drugs to minimize waste generation

Green Chemistry: A Simple Manual Apparatus for Potentiometric and Conductometric Micro-Titration of Small Samples for the Educational Laboratory

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