Microsatellite Instability in Interval Colon Cancers

Adenoma Detection Rate and Risk of Colorectal Cancer and Death

“…Previous studies have focused primarily on cancers occurring within 3 to 5 years after the colonoscopic examination; rapidly progressing adenomas or cancers that were present but not detected at the time of colonoscopy would presumably account for these interval cancers. 15,21,29,30,[33][34][35][36][37][38][39][40][41] The number of cancers detected in this study is similar to or lower than the numbers observed in other studies (which often evaluated cancers over a shorter period). 29,30 Interval cancers accounted for only 8.2% of all colorectal cancers detected in our study cohort, and the absolute risk of an interval cancer was relatively low (9.8 interval cancers per 10,000 person-years of follow-up in quintile 1 of adenoma detection rates and 4.8 interval cancers per 10,000 person-years of follow-up in quintile 5).…”

S3-Leitlinie – Kolorektales Karzinom

“…Diese setzen sich zusammen aus übersehenen Läsionen (miss rate), inkompletten Polypektomien sowie dem Auftreten schnell wachsender Tumore [428,430,432,621]. Die Festlegung der Untersuchungsintervalle nach Polypektomie hängen vom individuellen Risiko des Patienten ab.…”

Findings in the Distal Colorectum Are Not Associated With Proximal Advanced Serrated Lesions

“…These features likely account for the fact that the serrated pathway is a disproportionate contributor to interval CRC (CRC diagnosed relatively soon after colonoscopy). Cancers associated with the serrated pathway tend to occur in the proximal colon and their molecular signature overlaps significantly with interval CRC [21][22][23] .…”