Microrobots: A Needle‐Type Microrobot for Targeted Drug Delivery by Affixing to a Microtissue (Adv. Healthcare Mater. 7/2020)

Lee, Seungmin; Kim, Jin‐young; Kim, Junyoung; Hoshiar, Ali Kafash; Park, Jongeon; Lee, Sunkey; Kim, Jong-Hyun; Nelson, Bradley J.; Choi, Hongsoo

doi:10.1002/adhm.202070019

Cited by 6 publications

(7 citation statements)

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“…[298] A needle-type microrobot was used for paclitaxel targeted drug intracellular delivery. [299] Magnetic nanospears based on gold-nickel-silicon were designed and applied for precision, and targeted intracellular delivery of nucleic acids (Figure 10c). Nanomotors were functionalized via layer-by-layer assembly on the external spear layer with plasmids expressing enhanced green fluorescent protein.…”

Section: Intracellular Deliverymentioning

confidence: 99%

Medical Micro/Nanorobots in Precision Medicine

et al. 2020

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Advances in medical robots promise to improve modern medicine and the quality of life. Miniaturization of these robotic platforms has led to numerous applications that leverages precision medicine. In this review, the current trends of medical micro and nanorobotics for therapy, surgery, diagnosis, and medical imaging are discussed. The use of micro and nanorobots in precision medicine still faces technical, regulatory, and market challenges for their widespread use in clinical settings. Nevertheless, recent translations from proof of concept to in vivo studies demonstrate their potential toward precision medicine.

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Section: Intracellular Deliverymentioning

confidence: 99%

Medical Micro/Nanorobots in Precision Medicine

et al. 2020

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“…A representative example of this is the magnetic needle‐type robot presented by Lee et al allowing attachment on target microtissue thus offering stable drug delivery. [ 81 ] Targeting cancer therapy Park et al. developed a drug delivery system showing potential for hyperthermia therapy.…”

Section: Microroboticsmentioning

confidence: 99%

“…A representative example of this is the magnetic needle-type robot presented by Lee et al allowing attachment on target microtissue thus offering stable drug delivery. [81] Targeting cancer therapy Park et al developed a drug delivery system showing potential for hyperthermia therapy. [82] Implementing iron oxide nanoparticles in the microrobots' PEGgel matrix not only yields stimulus-responsive locomotion but also permits heating of the microrobot surrounding environment to temperatures above 40 °C -allowing for example cancer cells to suffer irreversible damage -by conversion of electromagnetic energy to heat.…”

Section: Applications Of Mobile Microswimmers and Microrobotsmentioning

confidence: 99%

Recent Advances in Multi‐Photon 3D Laser Printing: Active Materials and Applications

Mainik,

Spiegel,

Blasco

2023

Advanced Materials

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Since the pioneering work of Kawata and colleagues in 1997, multi‐photon 3D laser printing, also known as direct laser writing, has made significant advancements in a wide range of fields. Moreover, the development and commercialization of photocurable inks for this technique have expanded rapidly. One of the current trends is the transition from static to active printable materials, often referred to as 4D microprinting, which enables a new degree of control in the printed systems. This review focuses on four primary application areas: microrobotics, optics and photonics, microfluidics, and life sciences, highlighting recent progress and the crucial role of active materials, including liquid crystalline elastomers, hydrogels, shape memory polymers, and composites, among others. It also addresses ongoing challenges and provides insights into the future prospects in the different fields.

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“…Magnetic microrobots and nanoparticles are used for targeted drug delivery, cell transplantation, assistance during surgery, diagnostic imaging, and neural reconnection. [ 1–8 ] Microrobots can be loaded with drugs for targeted delivery, such as anticancer drugs that treat tumors. [ 9,10 ] Magnetic nanoparticles can also be used in targeted drug delivery, [ 2,11–13 ] overcoming the low load‐carrying capacity of an individual microrobot.…”

Section: Introductionmentioning

confidence: 99%

Virtual Reality‐Enabled Intuitive Magnetic Manipulation of Microrobots and Nanoparticles

Chowdhury,

Abbasi,

Gharamaleki

et al. 2024

Advanced Intelligent Systems

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Magnetic microrobots and nanoparticles offer unique capabilities for medical applications by granting unprecedented access to intricate and delicate anatomical structures. Nevertheless, an intuitive manipulation approach remains a challenge due to their small size and limited feedback. This study presents a new method for magnetic microrobot and nanoparticle control that employs virtual reality (VR), creating an immersive and realistic view of the bodily anatomy and the microrobot within. This study compares three manipulation modes: a traditional mode using 2D displays, VR mode using a VR headset and touch controllers, and VR autonomous programmed maneuvering. It is shown that VR‐assisted modes reduce the manipulation time by improving spatial awareness. Nanoparticles in a VR environment are also manipulated. The proposed method will find applications in terms of intuitive, immersive microrobots or magnetic nanoparticle control in complex biological environments, thus in many medical procedures and for drug and cell delivery. The immersive nature of this approach enhances the ability of the user to perceive and understand complex anatomical structures, facilitating better navigation within delicate environments; both dexterity and spatial awareness are improved. Thus, it is shown how microrobots and magnetic nanoparticles can be controlled using immersive simulations to improve both visualization and manipulation.

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Microrobots: A Needle‐Type Microrobot for Targeted Drug Delivery by Affixing to a Microtissue (Adv. Healthcare Mater. 7/2020)

Cited by 6 publications

References 0 publications

Medical Micro/Nanorobots in Precision Medicine

Medical Micro/Nanorobots in Precision Medicine

Recent Advances in Multi‐Photon 3D Laser Printing: Active Materials and Applications

Virtual Reality‐Enabled Intuitive Magnetic Manipulation of Microrobots and Nanoparticles

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